Alclometasone cream is a low to medium-potency topical steroid used in the treatment of steroid-responsive skin disorders.

It possesses anti-inflammatory, antipruritic, and vasoconstrictive properties.

Aclovate (Alclometasone dipropionate) Uses:

• A topical steroid called alclometasone is used to treat many skin disorders including eczema, psoriasis, and others by reducing swelling, itching, dryness, and pain.
• It is also used to treat drug-induced skin reactions. However, it should not be used to treat acne and yeast infections.
• Steroids can worsen acne and infections, especially yeast infections.
• The application of alclometasone dipropionate, like other topical steroids, should be avoided over the face, genitals, armpits, and breasts.

Alclometasone dipropionate for adult Steroid-responsive dermatoses:

Topical: 1-2 times per day, apply a thin coating to the afflicted region.

Reassessment of the diagnosis may be required if the improvement is not apparent within 2 weeks after control is attained; therapy should be stopped at that point.

Use in children:

Children 1 year of age or older:

• 2-3 times each day, apply a thin coating to the afflicted region.

Note:

• If control is attained, stop the therapy. Consider a different diagnosis when reevaluating if progress is not evident.
• Do not use it for more than three weeks in children. Apply occlusive dressings for refractory and deep-seated skin disorders.

Pregnancy Risk Factor C 

• Large portions of the body, lengthy periods of time, or excessive dosages of topical medications should not be used.
• Breastfeeding mothers should be cautious

Renal Dose:

• No dose adjustment is required.

Dose in Liver disease:

• No dose adjustment is required.

Alclometasone cream side effects:

Endocrine & metabolic:

• Cushing's syndrome
• Diabetes
• HPA axis suppression
• osteoporosis
• growth retardation4
• hypertension

Dermatologic:

• Acne
• hypopigmentation
• striae
• miliaria
• perioral dermatitis
• skin atrophy
• facial hair

Local side effects:

• burning
• erythema
• itching
• Dryness
• irritation
• papular rash
• folliculitis

Miscellaneous:

• Prolonged use may cause immunosuppression and Secondary infections can occur.

Contraindications to Alclometasone cream

• Hypersensitivity to any ingredient in the formulation, including alclometasone
• Apply over the face Apply to infected areas, such as yeast infections. 

Monitor:

• Long-term steroid use can suppress the hypothalamic-pituitary axis.
• Cortisol and ACTH stimulation test may be done if it is suspected. 

How to apply alclometasone cream?

• Exclusively for external usage. To clean, dry skin, apply a thin coating, and then gently massage it in.
• Keep your distance from the breasts, groyne, underarms, face, and eyes. If there are any open or weeping lesions present, they should not be utilised.
• Before and after using, wash your hands thoroughly.

Mechanism of Action of alclometasone dipropionate: 

• suppresses the synthesis of the enzymes required to minimise inflammation, stop mitotic activity, and produceSvasoconstriction.

Absorption

• Topical: Approximately 3% of topical medications are absorbed into the body after 8 hours.

International brands of alclometasone dipropionate:

• Acloderm
• Aclosone
• Aclovate
• Almeta
• Cloderm
• Delonal
• Demiderm
• Legederm
• Logoderm
• Lomesone
• Miloderme
• Modraderm
• Modrasone
• Perderm

Brands in Pakistan:

No brands available in Pakistan.