Glimepiride (Amaryl) - Uses, Dose, Side effects, MOA, Brands

In addition to diet and exercise, glimepiride (Amaryl), a long-acting third-generation sulfonylurea, is used to treat people with diabetes mellitus.

Glimepiride (Amaryl) Uses:

  • Diabetes mellitus, type 2:

    • Glimepiride is used as an adjunct to diet and exercise to improve diabetic control in adults with type 2 diabetes mellitus

Glimepiride (Amaryl) Dose in Adults

Glimepiride (Amaryl) Dose in the treatment of type 2 Diabetes mellitus: Oral:

  • Initially, it can be given as 1 to 2 mg once a day. 
  • It can be increased by 1 to 2 mg every 1 to 2 weeks, up to a maximum of 8 mg once per day, depending on how it responds.

Changing from long half-life agent therapy:

  • When switching from a long halflife treatment (such chlorpropamide) to glimepiride due to overlapping hypoglycemic effects, monitor the patient  carefully for hypoglycemia for 1 to 2 weeks.

Use in Children:

Not indicated.

Pregnancy Risk Category: C

  • Infants born to mothers who took a sulfonylurea during pregnancy can experience severe hypoglycemia that can last up to 10 days. 
  • There are not many studies on the effects of glimepiride during pregnancy.
  • Avoid exposure to it during pregnancy.
  • Congenital malformations and maternal hyperglycemia are associated with adverse pregnancy outcomes.
  • By maintaining maternal glucose and HbA1c levels as close to their goal levels as feasible, but without resulting in severe hypoglycemia, it is possible to prevent bad consequences from developing before conception and during pregnancy.
  • Pregnant women with diabetes should not be treated with glimepiride alone.

Use of limepiride during lactation

  • It is not known whether breast milk secretes it.
  • Clinically, hyperglycemia treatment with sulfonylurea must be evaluated.
  • The benefits of the therapy should outweigh any risks for breastfeeding mothers. To prevent adverse side effects.
  • Hypoglycemia should be monitored in infants.

Glimepiride (Amaryl) Dose in Kidney disease:

It can be taken as little as 1 mg daily at first. To avoid hypoglycemia, the dose titration should be conservative. If eGFR is 15mL/minute/1.73m2, consider alternative treatment.

Glimepiride (Amaryl) Dose in Liver disease:

  • It is not known if dose adjustments can be made in liver disease. 
  • The studies on dose adjustments are however limited.
  • Patients with cirrhosis should be cautiously titrated up to avoid hypoglycemia

Common Side Effects of Glimepiride (Amaryl):

  • Endocrine & metabolic:

    • Hypoglycemia

Less Common Side Effects of Glimepiride (Amaryl):

  • Central nervous system:

    • Dizziness
    • Headache
  • Gastrointestinal:

    • Nausea
  • Hepatic:

    • Increased serum ALT
  • Respiratory:

    • Flu-like symptoms
  • Miscellaneous:

    • Accidental injury

Contraindications to Glimepiride (Amaryl):

  • Hypersensitivity to this drug or the sulfonamides is a clear contraindication.
  • It is interesting to note that despite the fact that the FDA approved product labelling specifies that this medication  should not be taken with other sulfonamide-containing medications, the scientific validity of this claim has been questioned.
  • Due to similar physiochemical properties, cross-sensitities can be allergenic. It is therefore important to exercise caution.

Canadian labeling: Additional contraindications, but not in the US labeling

  • Pregnancy.
  • Breastfeeding
  • Type 1 diabetes.
  • Diabetic ketoacidosis, with or without coma
  • Grave renal or liver impairment

Warnings and precautions

  • Cardiovascular mortality

    • These oral hypoglycemic drugs are associated with higher morbidity and deaths than insulin or insulin plus diet.
    • However, large trials were not conducted to support the above-stated hypothesis.
    • Patients suffering from advanced atherosclerotic diseases should be prescribed additional anti-hyperglycemic agents.
  • Hypoglycemia

    • All sulfonylurea medications can cause severe hypoglycemia.
    • Hypoglycemia can be exacerbated by inadequate caloric intake or concomitant use of oral hypoglycemic drugs. It can also be worsened by alcohol ingestion.
    • It is important to exercise caution when prescribing this drug for frail and elderly diabetics.
  • Allergy to sulfonamide ("sulfa")

    • Wide ranging contraindications for patients who have previously experienced an adverse reaction to  sulfonamides are listed on FDA-approved product labels for drugs that contain sulfonamide chemical groups.
    • Crossreactivity is possible
    • Crossreactivity concerns have been raised for all compounds with the sulfonamide structural.
    • Recent studies have shown that cross-reactivity between non-antibiotic sulfonamides or antibiotic sulfonamides has been reduced.
    • Recent trials with non-antibiotics sulfonamide have shown that anaphylaxis is not common.
    • Less research has been done on type IV reactions, which are T-cell mediated and include skin rashes including  maculopapular rash. 
    • Based on the most recent results from several investigations, it is impossible to rule out this possibility.
    • Some clinicians will avoid treating patients with severe Stevens-Johnson syndrome (or TEN) if there are any prior cases.
  • Deficiency of Glucose-6phosphate dehydrogenase(G6PD) 

    • Patients with G6PD deficits may be more susceptible to hemolytic anaemia brought on by sulfonylureas.
    • Postmarketing surveillance has also shown cases in patients who have not been deficient in G6PD.
    • Patients with G6PD deficiency should exercise caution
  • Hepatic impairment

    • Hypoglycemia is more common in patients with hepatic impairment. It is recommended to be cautious.
  • Renal impairment

    • In renal diseases, it is a good idea to reduce your dose as it can lead to hypoglycemia.
  • Stress-related disorders:

    • When under stress or in a coma, oral hypoglycemic must be switched to insulin.

Glimepiride: Drug Interaction

Risk Factor C (Monitor therapy)

Ajmaline

Sulfonamides might make ajmaline more harmful or poisonous.  In particular, there may be an elevated risk for cholestasis.

Alcohol (Ethyl)

Sulfonylureas may increase Alcohol's harmful or toxic effects (Ethyl). There could be a flushing reaction.

Alpha-Lipoic Acid

May strengthen an anti-diabetic agent's hypoglycemic impact.

Aminolevulinic Acid (Topical)

Aminolevulinic Acid's photosensitizing impact may be enhanced by photosensitizing agents (Topical).

Androgens

Can make blood glucose lowering medications more effective at lowering blood sugar.  Exceptions: Danazol.

Antidiabetic Agents

Possibly makes hypoglycemia-associated agents more effective.

Beta-Blockers

Sulfonylureas' hypoglycemic impact might be strengthened. Betablockers that are cardioselective (such as acebutolol,  atenolol, metoprolol, and penbutolol) may be less dangerous than those that are nonselective.  As the initial sign of hypoglycemia, tachycardia seems to be concealed by all beta-blockers. Beta-blockers used intravenously most likely carry a lesser risk than those used systemically.  Levobunolol and metipranolol are exceptions.

Carbocisteine

Sulfonylureas may intensify Carbocisteine's harmful or hazardous effects.

Chloramphenicol (Systemic)

 

Particularly, sulfonylureas may intensify the negative effects of the alcohol contained in liquid formulations  of medicines containing carbocisteine. Sulfonylureas' metabolism might be slowed down.

Cimetidine

Sulfonylureas' serum levels might rise.

Cyclic Antidepressants

Sulfonylureas' hypoglycemic impact might be strengthened.

Dexketoprofen

Sulfonamides' harmful or poisonous effects could be amplified.

Direct Acting Antiviral Agents (HCV)

May strengthen an anti-diabetic agent's hypoglycemic impact.

Fibric Acid Derivatives

Sulfonylureas' hypoglycemic impact might be strengthened.

Guanethidine

May enhance the hypoglycemic effect of Antidiabetic Agents.

Herbs (Hypoglycemic Properties)

May enhance the hypoglycemic effect of HypoglycemiaAssociated Agents.

Hyperglycemia-Associated Agents

May diminish the therapeutic effect of Antidiabetic Agents.

Hypoglycemia-Associated Agents

May enhance the hypoglycemic effect of other HypoglycemiaAssociated Agents.

Hypoglycemia-Associated Agents

Antidiabetic Agents may enhance the hypoglycemic effect of Hypoglycemia-Associated Agents.

Lumacaftor

May decrease the serum concentration of CYP2C9 Substrates (High Risk with Inhibitors or Inducers). Lumacaftor may increase the serum concentration of CYP2C9 Substrates (High Risk with Inhibitors or Inducers).

Maitake

May enhance the hypoglycemic effect of Blood Glucose Lowering Agents.

Miconazole (Oral)

May enhance the hypoglycemic effect of Sulfonylureas. Miconazole (Oral) may increase the serum concentration of Sulfonylureas.

Monoamine Oxidase Inhibitors

Can make blood glucose lowering medications more effective at lowering blood sugar.

Pegvisomant

Can make blood glucose lowering medications more effective at lowering blood sugar.

Porfimer

The photosensitizing effect of Porfimer may be strengthened by photosensitizing agents.

Probenecid

Sulfonylureas may lessen their ability to attach to proteins.  Sulfonylurea serum levels may rise in response to probenecid.

Prothionamide

Can make blood glucose lowering medications more effective at lowering blood sugar.

Quinolones

Can make blood glucose lowering medications more effective at lowering blood sugar. Blood Glucose Lowering Agents' therapeutic impact may be lessened by quinolones.  In particular, the use of quinolones may result in a loss of blood sugar control if an agent is being used to treat diabetes.

RaNITIdine

Sulfonylureas' serum levels might rise.

Rifapentine

May lower the serum level of CYP2C9 substrates (High risk with Inducers).

Ritodrine

May reduce an anti-diabetic agent's therapeutic efficacy.

Salicylates

Can make blood glucose lowering medications more effective at lowering blood sugar.

Selective Serotonin Reuptake Inhibitors

Can make blood glucose lowering medications more effective at lowering blood sugar.

Sulfonamide Antibiotics

Sulfonylureas' hypoglycemic impact might be strengthened.

Thiazide and Thiazide-Like Diuretics

May reduce an anti-diabetic agent's therapeutic efficacy.

Verteporfin

Verteporfin's photosensitizing effect may be strengthened by photosensitizing agents.

Vitamin K Antagonists (eg, warfarin)

The anticoagulant action of Vitamin K antagonists may be increased by sulfonylureas.  Sulfonylureas may have a greater hypoglycemia effect when used with vitamin K antagonists.

Voriconazole

Sulfonylureas' serum levels might rise.

Risk Factor D (Consider therapy modification)

Colesevelam

May lower the level of glimepiride in the serum.  Treatment: Glimepiride should be administered at least 4 hours before colestipol.

Dabrafenib

May lower the serum level of CYP2C9 substrates (High risk with Inducers).  Management: When possible, look for CYP2C9 substrate substitutes.  If concurrent therapy cannot be avoided, pay special attention to the substrate's clinical consequences (particularly therapeutic effects).

Dipeptidyl Peptidase-IV Inhibitors

Sulfonylureas' hypoglycemic impact might be strengthened. When starting treatment with a dipeptidyl peptidase-IV inhibitor, take into account lowering the dose of sulfonylurea and keep an eye out for hypoglycemia in the patients.

Enzalutamide

May lower the serum level of CYP2C9 substrates (High risk with Inducers). Treatment: Enzalutamide should not be used  concurrently with CYP2C9 substrates that have a limited therapeutic index. Enzalutamide use, like with the use of any other  CYP2C9 substrate, should be done with caution and under close observation.

Fluconazole

Sulfonylureas' serum levels might rise. Management: When possible, look for alternatives.  If fluconazole is started or the dose is increased, keep a cautious eye out for any increased or  decreased effects of sulfonylureas if the two medications are being used together.

Glucagon-Like Peptide-1 Agonists

Sulfonylureas' hypoglycemic impact might be strengthened. Management: When used with glucagonlike peptide-1 agonists, sulfonylurea dose reductions should be taken into account.

Metreleptin

Sulfonylureas' hypoglycemic impact might be strengthened. Management: To reduce the risk for hypoglycemia when using  metreleptin concurrently, sulfonylurea dosage changes (including possibly significant decreases) may be necessary.  Observe carefully.

MiFEPRIStone

May increase the serum concentration of CYP2C9 Substrates (High risk with Inhibitors). Management: Use CYP2C9 substrates at the lowest recommended dose, and monitor closely for adverse effects, during and in the 2 weeks following mifepristone treatment.

RifAMPin

May lower the level of sulfonylureas in the serum. Management: When possible, look for substitutions for these mixtures.  If rifampin is started or the dose is increased, keep a watchful eye out for therapeutic effects of  sulfonylureas that are lowered or amplified.

Sodium-Glucose Cotransporter 2 (SLGT2) Inhibitors

Sulfonylureas' hypoglycemic impact might be strengthened. When starting therapy with a sodium-glucose cotransporter 2 inhibitor,  take into account lowering the dose of sulfonylurea and keep an eye out for hypoglycemia in your patients.

Thiazolidinediones

May enhance the hypoglycemic effect of Sulfonylureas. Management: Consider sulfonylurea dose adjustments in patients taking thiazolidinediones and monitor for hypoglycemia.

Risk Factor X (Avoid combination)

Aminolevulinic Acid (Systemic

Aminolevulinic Acid's photosensitizing impact may be enhanced by photosensitizing agents (Systemic).

Mecamylamine

Sulfonamides may intensify Mecamylamine's harmful or hazardous effects.

Mitiglinide

Sulfonylureas' harmful or hazardous effects could be increased.

 

Monitoring parameters:

  • You should be aware of symptoms include extreme appetite, perspiration, and exhaustion.
  • Patients who have stable glycemic control and are making progress toward their treatment objectives should have their blood sugar and HbA1c checked at least twice a year.
  • Patients who are on therapy change or who are not meeting these targets must test every three months.
  • Tests of renal function.

How to administer Glimepiride (Amaryl)?

Oral:

  • Take the following instructions orally.
  • Patients who are NPOs or have a reduced caloric intake might need to be given lower doses in order to prevent hypoglycemia.

Mechanism of action of Glimepiride (Amaryl):

It raises insulin sensitivity at peripheral target sites, enhances pancreatic beta cell insulin production, and decreases hepatic glucose output.

The onset of action:

  • Peak effect: Blood glucose reductions: 2 to 3 hours

Duration:

  • 24 hours

Absorption:

  • 100%

Protein binding:

  • >99.5%

Metabolism:

  • Hepatic oxidation via CYP2C9 to M1 metabolite (~33% activity of parent compound); further oxidative metabolism to inactive M2 metabolite

Half-life elimination:

  • 5 to 9 hours

Time to peak, plasma:

  • 2 to 3 hours

Excretion:

  • Urine (60%, 80% to 90% as M1 and M2 metabolites);
  • feces (40%, 70% as M1 and M2 metabolites)

International Brand Names of Glimepiride:

  • Amaryl
  • APO-Glimepiride
  • GEN-Glimepiride
  • NOVO-Glimepiride
  • PMS-Glimepiride
  • RATIO-Glimepiride
  • SANDOZ Glimepiride
  • Acotril
  • Aforglim
  • Amadiab
  • Amagreen
  • Amapirid
  • Amarax
  • Amarel
  • Amarine
  • Amaryl
  • Amarylle
  • Amepirise
  • Amorin
  • Arya
  • Aylide
  • Azulix
  • Azulix-1
  • Azulix-2
  • Azulix-4
  • Betaglid
  • Betastimul
  • Canzeal
  • Daniglim
  • Daol
  • Diaglime
  • Diaglip
  • Dialosa
  • Diameril
  • Diapirid
  • Diapride
  • Diaryl
  • Dimaril
  • Dimirel
  • Efinex
  • Endial
  • Euglim
  • Fertin
  • Getryl
  • Getzalim
  • Glaryl
  • Glazer
  • Glemaz
  • Glemep
  • Glim
  • Glimaccord
  • Glimaryl
  • Glimed 1
  • Glimep
  • Glimepid
  • Glimepigen
  • Glimeryl
  • Glimide
  • Glimirid
  • Glimuilin-2
  • Glimulin
  • Glimvaz
  • Glimxl
  • Gliparil
  • Glipiryl
  • Glorion
  • Glucozen
  • Gludine
  • Gluvas
  • Glypride
  • Hanmaryl
  • Hexan
  • K-Glim
  • Losu-3
  • Mapryl
  • Melital
  • Mepigryl
  • Mericle
  • Metrix
  • Miaryl
  • Neoacotril
  • Norizec
  • Oltar
  • Orbide
  • Pimaryl
  • Sinperan
  • Solosa
  • Sulfast
  • Velacom
  • Versibet

Glimepiride Brand Names in Pakistan:

Glimepiride 1 Mg Tablets in Pakistan

A-Glim Linear Pharma
Agpride Agp (Private) Ltd.
Agyl Webros Pharmaceuticals
Amarit Reko Pharmacal (Pvt) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Broglipe Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Campride Chas. A. Mendoza
Caypride Caylex Pharmaceuticals (Pvt) Ltd.
Dazemep Lowitt Pharmaceuticals (Pvt) Ltd
Diabold Barrett Hodgson Pakistan (Pvt) Ltd.
Diaglide Polyfine Chempharma (Pvt) Ltd.
Diaglim Askari Pharmaceuticals.
Dialex Pulse Pharmaceuticals
Diatrol Martin Dow Pharmaceuticals (Pak) Ltd.
Dibnil Jinnah Pharmaceuticals
Diryl Kurative Pak (Pvt) Ltd
Evopride Pharmevo (Pvt) Ltd.
G-Helix Helix Pharma (Private) Limited
G.P.D. Xenon Pharmaceuticals (Pvt) Ltd.
Gamaryl Akson Pharmaceuticals (Pvt) Ltd.
Gempride Atco Laboratories Limited
Genlip Genix Pharma (Pvt) Ltd
Getryl Getzglim Getz Pharma Pakistan (Pvt) Ltd.
Glactil Aries Pharmaceuticals (Pvt) Ltd
Glanyl Axis Pharmaceuticals
Glemex The Schazoo Laboratories Ltd.
Glemser Panacea Pharmaceuticals
Gligo Saffron Pharmaceutical Company
Gliguard Epla Laboratories (Pvt) Ltd.
Glimecide Werrick Pharmaceuticals
Glimer Amson Vaccines & Pharma (Pvt) Ltd.
Glimryl Alliance Pharmaceuticals (Pvt) Ltd.
Glimtide Beste Pharma (Pvt) Ltd.
Glio Macter International (Pvt) Ltd.
Glioptim Merck Private Ltd.
Glip Mass Pharma (Private) Limited
Gliride Pfizer Laboratories Ltd.
Glitop Helix Pharma (Private) Limited
Glomet Global Pharmaceuticals
Glory Novartis Pharma (Pak) Ltd
Glow Adamjee Pharmaceuticals (Pvt) Ltd.
Gluconorm Agp (Private) Ltd.
Glucoride Star Laboratories (Pvt) Ltd.
Glunex Epharm Laboratories
Glyper Efroze Chemical Industries (Pvt) Ltd.
Glyset Wilshire Laboratories (Pvt) Ltd.
Gpride Sami Pharmaceuticals (Pvt) Ltd.
Initial Hoora Pharma
Lea L Leads Pharma (Pvt) Ltd
Leadryl Leads Pharma (Pvt) Ltd
Limoride Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Medipride Medipak Limited
Megapride Mega Pharmaceuticals (Pvt) Ltd
Melnorm Danas Pharmaceuticals (Pvt) Ltd
Mipride Karachi Chemical Industries
Neoglim Everest Pharmaceuticals
Noaryl Noa Hemis Pharmaceuticals
Norlim Nabiqasim Industries (Pvt) Ltd.
Nyloride Highnoon Laboratories Ltd.
Omarid Shawan Pharmaceuticals
Orinase Consolidated Chemical Laboratories (Pvt) Ltd.
Pamaryl Himont Pharmaceuticals (Pvt) Ltd.
Pharpride Pharmacare Laboratories (Pvt) Ltd.
Praba Tagma Pharma (Pvt) Ltd.
Retryl Rock Pharmaceuticals
Safgo Saffron Pharmaceutical Company
Steady Bryon Pharmaceuticals (Pvt) Ltd.
Suglow 3h Hamaz Pharmaceutical (Pvt) Ltd.
Sugral Rakaposhi Pharmaceutical (Pvt) Ltd.
V Pride V Care International
V-Pride V Care International
Zeenaryl High - Q International

 

Glimepiride 2 Mg Tablets in Pakistan

A-Glim Linear Pharma
Agpride Agp (Private) Ltd.
Agyl Webros Pharmaceuticals
Amarit Reko Pharmacal (Pvt) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Bamaryl Orta Labs. (Pvt) Ltd.
Broglipe Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Campride Chas. A. Mendoza
Caypride Caylex Pharmaceuticals (Pvt) Ltd.
Dazemep Lowitt Pharmaceuticals (Pvt) Ltd
Diabold Barrett Hodgson Pakistan (Pvt) Ltd.
Diaglide Polyfine Chempharma (Pvt) Ltd.
Diaglim Askari Pharmaceuticals.
Diatrol Martin Dow Pharmaceuticals (Pak) Ltd.
Dibnil Jinnah Pharmaceuticals
Difree Friends Pharma (Pvt) Ltd
Eperide Flow Pharmaceuticals (Pvt) Ltd.
Evopride Pharmevo (Pvt) Ltd.
G-Helix Helix Pharma (Private) Limited
G-Taz Ambrosia Pharmaceuticals
G.P.D. Xenon Pharmaceuticals (Pvt) Ltd.
Gamaryl Akson Pharmaceuticals (Pvt) Ltd.
Gempride Atco Laboratories Limited
Genlip Genix Pharma (Pvt) Ltd
Geopride Geofman Pharmaceuticals
Getryl Getzglim Getz Pharma Pakistan (Pvt) Ltd.
Glactil Aries Pharmaceuticals (Pvt) Ltd
Glanyl Axis Pharmaceuticals
Glemex The Schazoo Laboratories Ltd.
Glemser Panacea Pharmaceuticals
Gligo Saffron Pharmaceutical Company
Gliguard Epla Laboratories (Pvt) Ltd.
Glimecide Werrick Pharmaceuticals
Glimer Amson Vaccines & Pharma (Pvt) Ltd.
Glimryl Alliance Pharmaceuticals (Pvt) Ltd.
Glimtide Beste Pharma (Pvt) Ltd.
Glio Macter International (Pvt) Ltd.
Glioptim Merck Private Ltd.
Glip Mass Pharma (Private) Limited
Gliride Pfizer Laboratories Ltd.
Glitop Helix Pharma (Private) Limited
Glory Novartis Pharma (Pak) Ltd
Glow Adamjee Pharmaceuticals (Pvt) Ltd.
Glucoglin Rehmat Pharma
Gluconorm Agp (Private) Ltd.
Glucoride Star Laboratories (Pvt) Ltd.
Glunex Epharm Laboratories
Glyper Efroze Chemical Industries (Pvt) Ltd.
Glyset Wilshire Laboratories (Pvt) Ltd.
Gpride Sami Pharmaceuticals (Pvt) Ltd.
Initial Hoora Pharma
Lea L Leads Pharma (Pvt) Ltd
Leadryl Leads Pharma (Pvt) Ltd
Limoride Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Medipride Medipak Limited
Mediryl Mediate Pharmaceuticals (Pvt) Ltd
Megapride Mega Pharmaceuticals (Pvt) Ltd
Melnorm Danas Pharmaceuticals (Pvt) Ltd
Mipride Karachi Chemical Industries
Neoglim Everest Pharmaceuticals
Noaryl Noa Hemis Pharmaceuticals
Norlim Nabiqasim Industries (Pvt) Ltd.
Nyloride Highnoon Laboratories Ltd.
Omarid Shawan Pharmaceuticals
Orinase Consolidated Chemical Laboratories (Pvt) Ltd.
Pamaryl Himont Pharmaceuticals (Pvt) Ltd.
Pharpride Pharmacare Laboratories (Pvt) Ltd.
Praba Tagma Pharma (Pvt) Ltd.
Raypride Ray Pharma (Pvt) Ltd
Retryl Rock Pharmaceuticals
Safgo Saffron Pharmaceutical Company
Steady Bryon Pharmaceuticals (Pvt) Ltd.
Suglow 3h Hamaz Pharmaceutical (Pvt) Ltd.
Sugral Rakaposhi Pharmaceutical (Pvt) Ltd.
Sunpride Batala Pharmaceuticals.
V Pride V Care International
V-Pride V Care International
Wipride Wise Pharmaceuticals (Pvt) Ltd
Zeenaryl High - Q International

 

Glimepiride 3 Mg Tablets in Pakistan

Agpride Agp (Private) Ltd.
Amarit Reko Pharmacal (Pvt) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Broglipe Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Campride Chas. A. Mendoza
Caypride Caylex Pharmaceuticals (Pvt) Ltd.
Diabold Barrett Hodgson Pakistan (Pvt) Ltd.
Diaglim Askari Pharmaceuticals.
Diatrol Martin Dow Pharmaceuticals (Pak) Ltd.
Dibnil Jinnah Pharmaceuticals
Evopride Pharmevo (Pvt) Ltd.
G-Helix Helix Pharma (Private) Limited
G.P.D. Xenon Pharmaceuticals (Pvt) Ltd.
Gamaryl Akson Pharmaceuticals (Pvt) Ltd.
Gempride Atco Laboratories Limited
Genlip Genix Pharma (Pvt) Ltd
Getryl Getzglim Getz Pharma Pakistan (Pvt) Ltd.
Glactil Aries Pharmaceuticals (Pvt) Ltd
Glanyl Axis Pharmaceuticals
Glemex The Schazoo Laboratories Ltd.
Gligo Saffron Pharmaceutical Company
Glimecide Werrick Pharmaceuticals
Glimer Amson Vaccines & Pharma (Pvt) Ltd.
Glimryl Alliance Pharmaceuticals (Pvt) Ltd.
Glio Macter International (Pvt) Ltd.
Glioptim Merck Private Ltd.
Gliride Pfizer Laboratories Ltd.
Glitop Helix Pharma (Private) Limited
Glory Novartis Pharma (Pak) Ltd
Glow Adamjee Pharmaceuticals (Pvt) Ltd.
Gluconorm Agp (Private) Ltd.
Glunex Epharm Laboratories
Glyper Efroze Chemical Industries (Pvt) Ltd.
Glyset Wilshire Laboratories (Pvt) Ltd.
Initial Hoora Pharma
Lea L Leads Pharma (Pvt) Ltd
Leadryl Leads Pharma (Pvt) Ltd
Limoride Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Medipride Medipak Limited
Megapride Mega Pharmaceuticals (Pvt) Ltd
Neoglim Everest Pharmaceuticals
Noaryl Noa Hemis Pharmaceuticals
Norlim Nabiqasim Industries (Pvt) Ltd.
Nyloride Highnoon Laboratories Ltd.
Omarid Shawan Pharmaceuticals
Orinase Consolidated Chemical Laboratories (Pvt) Ltd.
Pamaryl Himont Pharmaceuticals (Pvt) Ltd.
Praba Tagma Pharma (Pvt) Ltd.
Raypride Ray Pharma (Pvt) Ltd
Retryl Rock Pharmaceuticals
Safgo Saffron Pharmaceutical Company
Steady Bryon Pharmaceuticals (Pvt) Ltd.
Suglow 3h Hamaz Pharmaceutical (Pvt) Ltd.
Sugral Rakaposhi Pharmaceutical (Pvt) Ltd.
Sunpride Batala Pharmaceuticals.
V Pride V Care International
V-Pride V Care International
Zeenaryl High - Q International

 

Glimepiride 4 Mg Tablets in Pakistan

Agpride Agp (Private) Ltd.
Amarit Reko Pharmacal (Pvt) Ltd.
Amaryl Sanofi Aventis (Pakistan) Ltd.
Bamaryl Orta Labs. (Pvt) Ltd.
Broglipe Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Campride Chas. A. Mendoza
Caypride Caylex Pharmaceuticals (Pvt) Ltd.
Diabold Barrett Hodgson Pakistan (Pvt) Ltd.
Diaglim Askari Pharmaceuticals.
Diatrol Martin Dow Pharmaceuticals (Pak) Ltd.
Dibnil Jinnah Pharmaceuticals
Evopride Pharmevo (Pvt) Ltd.
G-Helix Helix Pharma (Private) Limited
G.P.D. Xenon Pharmaceuticals (Pvt) Ltd.
Gamaryl Akson Pharmaceuticals (Pvt) Ltd.
Gempride Atco Laboratories Limited
Genlip Genix Pharma (Pvt) Ltd
Getryl Getzglim Getz Pharma Pakistan (Pvt) Ltd.
Glactil Aries Pharmaceuticals (Pvt) Ltd
Glanyl Axis Pharmaceuticals
Glemex The Schazoo Laboratories Ltd.
Glemser Panacea Pharmaceuticals
Gligo Saffron Pharmaceutical Company
Glimecide Werrick Pharmaceuticals
Glimer Amson Vaccines & Pharma (Pvt) Ltd.
Glimryl Alliance Pharmaceuticals (Pvt) Ltd.
Glimtide Beste Pharma (Pvt) Ltd.
Glio Macter International (Pvt) Ltd.
Glioptim Merck Private Ltd.
Glip Mass Pharma (Private) Limited
Gliride Pfizer Laboratories Ltd.
Glitop Helix Pharma (Private) Limited
Glory Novartis Pharma (Pak) Ltd
Glow Adamjee Pharmaceuticals (Pvt) Ltd.
Gluconorm Agp (Private) Ltd.
Glunex Epharm Laboratories
Glyper Efroze Chemical Industries (Pvt) Ltd.
Glyset Wilshire Laboratories (Pvt) Ltd.
Gpride Sami Pharmaceuticals (Pvt) Ltd.
Initial Hoora Pharma
Lea L Leads Pharma (Pvt) Ltd
Leadryl Leads Pharma (Pvt) Ltd
Limoride Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Medipride Medipak Limited
Mediryl Mediate Pharmaceuticals (Pvt) Ltd
Megapride Mega Pharmaceuticals (Pvt) Ltd
Melnorm Danas Pharmaceuticals (Pvt) Ltd
Neoglim Everest Pharmaceuticals
Noaryl Noa Hemis Pharmaceuticals
Norlim Nabiqasim Industries (Pvt) Ltd.
Nyloride Highnoon Laboratories Ltd.
Omarid Shawan Pharmaceuticals
Orinase Consolidated Chemical Laboratories (Pvt) Ltd.
Pamaryl Himont Pharmaceuticals (Pvt) Ltd.
Raypride Ray Pharma (Pvt) Ltd
Retryl Rock Pharmaceuticals
Safgo Saffron Pharmaceutical Company
Steady Bryon Pharmaceuticals (Pvt) Ltd.
Suglow 3h Hamaz Pharmaceutical (Pvt) Ltd.
Sugral Rakaposhi Pharmaceutical (Pvt) Ltd.
V Pride V Care International
V-Pride V Care International
Wipride Wise Pharmaceuticals (Pvt) Ltd
Zeenaryl High - Q International

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