Diclofenac is available as Diclofenac sodium or potassium in tablets, capsules, Gel, Powder, and injection formulation. It is a non-selective COX (cyclo-oxygenase) inhibitor with potent antipyretic, anti-inflammatory, and pain-relieving properties.

Indications of Diclofenac:

• Ankylosing spondylitis (delayed-release tablets only):
  • It is indicated for acute or long-term use in the relief of signs and symptoms of ankylosing spondylitis.
• Dysmenorrhea (immediate-release tablets only):
  • It is effective in the treatment of primary dysmenorrhea.
• Migraine (powder for oral solution only):
  • Diclofenac is given for acute treatment of migraine attacks with or without aura in adults.
• Osteoarthritis (immediate-release, extended-release, and delayed-release tablets; capsules [Zorvolex]; and suppositories [Canadian product] only):
  • It is helpful in relieving signs and symptoms of osteoarthritis.
• Pain
  • Capsules/immediate-release tablets only:
    • Relief of mild to moderate acute pain.
  • Injection only:
    • Management of mild to moderate pain and moderate to severe pain (alone or concurrently with opioid analgesics) in adults.
• Rheumatoid arthritis (immediate-release, extended-release, and delayed-release tablets; and suppositories [Canadian product] only):
  • It is effective in relieving the signs and symptoms of rheumatoid arthritis.

 

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Diclofenac dose in adults:

Note: Due to the risk of vascular events such as MI, stroke, the dose should not exceed 100 mg/day. Note: Dyloject (diclofenac injection) has been discontinued in the United States for more than 1 year.

Diclofenac dose in the treatment of Ankylosing spondylitis:

• Delayed-release tablet:
  • 25 mg per oral 4 times daily and 25 mg at bedtime as needed.

Diclofenac dose in the treatment of Migraine: 

• Powder for oral solution:
  • 50 mg (one packet) as a single dose; safety and efficacy of a second dose have not been established.

Diclofenac dose in the treatment of Osteoarthritis:

• Immediate-release tablet:
  • Oral: 50 mg 2 to 3 times daily.
  • Delayed-release tablet: 50 mg 2 to 3 times daily or 75 mg twice daily.
  • Extended-release tablet: 100 mg once daily
• Immediate-release capsule:
  • Oral: Zorvolex (diclofenac acid): 35 mg 3 times daily.
• Rectal suppository [Canadian product]:
  • Insert 50 mg or 100 mg rectally as single dose to substitute for a final oral daily dose.
  • maximum combined dose [rectal and oral]: 100 mg/day.

Diclofenac dose in the treatment of mild to moderate Pain:

• Immediate-release tablet:
  • Oral: 50 mg 3 times daily;
  • may administer 100 mg as an initial dose, followed by 50 mg 3 times daily.
• Immediate-release capsule:
  • Zipsor (diclofenac potassium): 25 mg per oral 4 times daily.
  • Zorvolex (diclofenac acid): 18 mg or 35 mg per oral 3 times daily.
  • IV: 37.5 mg every 6 hours as needed; adjust the frequency according to patient response.
  • maximum: 150 mg/day.

Diclofenac dose in the treatment of primary dysmenorrhea: 

• Immediate-release tablet:
  • 50 mg 3 times daily; may administer 100 mg as an initial dose, followed by 50 mg 3 times daily.

Diclofenac dose in patients with Rheumatoid arthritis: 

• Immediate-release tablet:
  • 50 mg per oral 3 to 4 times daily.
• Delayed-release tablet:
  • 50 mg per oral 3 to 4 times daily or 75 mg twice daily.
• Extended-release tablet:
  • 100 mg once daily; may increase to 100 mg twice daily.
• Rectal suppository [Canadian product]:
  • Insert 50 mg or 100 mg rectally as single dose to substitute for the final oral daily dose.
  • maximum combined dose [rectal and oral]: 100 mg/day.

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Diclofenac dose in children:

Note: Different oral formulations are not bioequivalent; do not interchange product.

Diclofenac dose in the treatment of Juvenile idiopathic arthritis:

• Children and Adolescents:
  • Immediate release tablet:
    • 2 to 3 mg/kg/day per oral in divided doses 2 to 4 times/day.
    • maximum daily dose: 150 mg/day.

Diclofenac dose in the treatment of migraine:

• Adolescents ≥18 years:
  • Oral solution: 50 mg (one packet) as a single dose at the time of migraine onset; safety and efficacy of a second dose have not been established.

 

 

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Pregnancy Risk Factor C/D (≥30 weeks gestation)

• Diclofenac can cross the placenta. Some studies have shown that NSAIDs in utero can cause birth defects. However, the data is inconsistent.
• Some non-teratogenic effects can be caused by NSAIDs in utero, such as prenatal constriction, persistent pulmonary hypertension, oligohydramnios and necrotizing enterocolitis.
• Postnatal resistance to the closure of the ductus Arteriosus may occur.
• Diclofenac's product label clearly states that diclofenac should not be used starting at 30 weeks gestation because of the potential for premature closure of the ductus arteriosus.
• Mild rheumatoid-arthritis flares in pregnancy can be treated with NSAIDs. However, they should be avoided during the early and later trimesters.
• For migraines that occur during pregnancy, alternative agents to diclofenac may be used.
• You can reverse infertility by stopping taking NSAIDs for a prolonged period.
• The drug should be stopped by women who are having trouble conceiving and those who are undergoing fertility treatment.
• NSAIDs taken close to conception increase the risk of miscarriage.

Diclofenac use during breastfeeding:

• Breast milk contains diclofenac.
• When diclofenac was calculated from the highest breastmilk concentration, the relative infant dose (RID), is 0.5% to 0.755%.
• This is compared to an infant therapeutic dosage of 2 to 3 mg/kg/day.
• If the RID is less than 10%, breastfeeding is acceptable. However, breastfeeding should not be done if it is more than 25%.
• The highest possible milk concentration (100 mg/L) is used to calculate the infant's daily breast milk dose of 0.015 mg/kg/day.
•  This milk concentration was calculated after maternal administration of oral diclofenac 150mg/day.
• Postpartum mothers who want to breastfeed can take NSAIDs. However, alternative agents are possible.
• Avoid NSAIDs for breastfeeding women who have platelet dysfunction or thrombocytopenia.

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Diclofenac Dose adjustment in renal disease:

Oral Diclofenac:

• Mild or moderate impairment:
  • No dosage adjustment necessary.
• Significant impairment or advanced renal disease:
  • Use is not recommended.

Diclofenac Injections:

• Mild impairment:
  • There are no dosage adjustments provided in the manufacturer's labeling.
• Moderate to severe impairment:
  • Use is not recommended; contraindicated in patients in the perioperative period and who are at risk for volume depletion.
• KDIGO 2012 guidelines provide the following recommendations for NSAIDs:
  • eGFR 30 to <60 mL/minute/1.73 m²:
    • In patients with intercurrent disease that increases risk of acute kidney injury, it should be stopped temporarily.
  • eGFR <30 mL/minute/1.73 m²:
    • Use should be avoided.

Diclofenac Dose adjustment in liver disease:

• There are no dosage adjustments provided in the manufacturer's labeling; however, may require dosage adjustment due to extensive hepatic metabolism. Additional product-specific recommendations:
  • Cambia: Lowest effective dose for the shortest duration possible should be used.
  • Zipsor/Zorvolex: Initial: Treatment should be started at the lowest dose; if efficacy is not achieved with the lowest dose,therapy should be stopped.

Diclofenac Injections:

• Mild impairment:
  • No dosage adjustment necessary.
• Moderate to severe impairment:
  • Use is not recommended (has not been studied).

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Side effects of Diclofenac Injections:

• Cardiovascular:
  • Edema
  • Cerebrovascular Accident
  • Hypertension
  • Myocardial Infarction
  • Significant Cardiovascular Event
• Central Nervous System:
  • Headache
  • Dizziness
• Dermatologic:
  • Pruritus
  • Skin Rash
  • Exfoliative Dermatitis
  • Stevens-Johnson Syndrome
  • Toxic Epidermal Necrolysis
• Endocrine & Metabolic:
  • Fluid Retention
• Gastrointestinal:
  • Constipation
  • Abdominal Pain
  • Diarrhea
  • Dyspepsia
  • Esophageal Perforation
  • Flatulence
  • Gastrointestinal Ulcer
  • Heartburn
  • Intestinal Perforation
  • Nausea
  • Vomiting
• Hematologic & Oncologic:
  • Anemia
  • Hemorrhage
  • Prolonged Bleeding Time
• Hepatic:
  • Increased Liver Enzymes
  • Increased Serum Transaminases
  • Increased Serum ALT
  • Increased Serum AST
• Hypersensitivity:
  • Anaphylactoid Reaction
• Local:
  • Infusion Site Reaction
  • Extravasation
• Otic:
  • Tinnitus
• Renal:
  • Renal Insufficiency
• Miscellaneous:
  • Wound Healing Impairment
  • Gastrointestinal Inflammation

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Side effects of Oral Diclofenac:

Common Side Effects Of Diclofenac:

• Cardiovascular:
  • Edema
• Hepatic:
  • Increased Serum Transaminases

Uncommon Side Effects Of Diclofenac:

• Cardiovascular:
  • Hypertension
• Central Nervous System:
  • Headache
  • Procedural Pain
  • Dizziness
  • Falling
• Dermatologic:
  • Pruritus
  • Skin Rash
• Gastrointestinal:
  • Constipation
  • Nausea
  • Diarrhea
  • GI Adverse Effects
  • Abdominal Pain
  • Vomiting
  • Dyspepsia
  • Flatulence
  • Heartburn
  • Abdominal Discomfort
  • Duodenal Ulcer
• Genitourinary:
  • Urinary Tract Infection
• Hematologic & Oncologic:
  • Bruise
  • Anemia
  • Prolonged Bleeding Time
• Hepatic:
  • Increased Serum ALT
  • Increased Serum AST
• Infection:
  • Influenza
• Neuromuscular & Skeletal:
  • Osteoarthritis
  • Arthralgia
  • Back Pain
  • Limb Pain
• Renal:
  • Renal Function Abnormality
• Otic:
  • Tinnitus
• Renal:
  • Increased Serum Creatinine
  • Renal Function Abnormality
• Respiratory:
  • Upper Respiratory Tract Infection
  • Nasopharyngitis
  • Sinusitis
  • Cough
  • Bronchitis

Rectal suppository [Canadian product]:

• Also refer to adverse reactions associated with oral formulations.

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Contraindications to Diclofenac:

• Hypersensitivity to diclofenac (eg anaphylactoid reaction, severe skin reactions) or bovine proteins (Zipsor only), or any component of formulation
• History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
• Patients with severe to moderate renal impairment during the perioperative period, and those at high risk of volume depletion (injection only)
• Use in the CABG setting
• Canadian labeling: Additional contraindications not in US labeling
• Patients under 16 years old (suppository, tablet), or 18 year of age (packet only).
• Third trimester of pregnancy, breastfeeding
• Hyperkalemia
• Peptic ulcer/ active gastric/ duodenal/ peptic disease
• Active GI bleeding or perforation, region ulcer or enteritis or gastritis, gastritis or ulcerative colitis or recurrent or repeated ulceration
• Inflammatory bowel disease
• Recent history of bleeding or inflammatory lesions in rectum/anus (suppository only).
• Other bleeding disorders or cerebrovascular bleeding
• Active hepatic disease; severe hepatic impairment
• Severe renal impairment (CrCl >30 mL/minute), or deteriorating renal disease

Warnings and precautions

• Anaphylactoid reactions
  • Patients may experience anaphylactoid reactions even if they have not been exposed to it before.
  • Patients with the "aspirin trifecta" (bronchial asthma and aspirin intolerance, rhinitis) are at greater risk.
  • It is not recommended to use NSAIDs or aspirin therapy in patients with bronchospasm or asthma.
• Cardiovascular events: [US Boxed Warn]
  • NSAID therapy can cause fatal cardiovascular thrombotic events such as stroke and MI.
  • This risk can occur during treatment, and it may increase as the duration of use is prolonged.
  • The relative risk of cardiovascular events seems to be the same for those with and without cardiovascular disease. However, in patients with known risk factors or cardiovascular disease, and those who receive higher doses of medication, the absolute risk is high.
  • Monitorizing BP is important as it could lead to new-onset hypertension, exacerbation, or worsening of hypertension. NSAIDs can also affect the response to ACE inhibitors, thiazide dialutics, or loop diuretics. This may increase your risk of cardiovascular events.
  • Patients with edema should not use it due to the possibility of fluid retention and sodium buildup.
  • Patients with heart failure should avoid using this product.
  • Patients who have had recent MI should not use the device unless they are comfortable with the risk of developing cardiovascular thrombotic complications.
  • To minimize cardiovascular events, patients should receive the lowest effective dose over a shorter time period to meet their individual goals.
  • Patients at high risk should be treated using alternate therapies.
• CNS effects
  • It is possible to experience drowsiness, dizziness and blurred vision as well as other neurologic effects that can lead to impairments in physical or mental abilities. Operating machinery or driving is something patients should be aware of.
  • Therapy should be stopped if blurred or reduced vision is present. An ophthalmologic exam should also be performed.
  • Patients who have been using long-term medication should be evaluated periodically.
• [US Boxed Warning]: GI events
  • NSAIDs can cause fatal gastrointestinal inflammation, ulceration and bleeding as well as perforation.
  • Patients with a history of peptic ulcer disease or GI bleeding are at greater risk.
  • These events can occur without warning and at any time during therapy.
  • Patients suffering from active GI bleeding should not take NSAIDs.
  • Patients with a history or tendency to have acute lower GI bleeding should not receive non-aspirin NSAIDs, especially if they are suffering from angioectasias or diverticulosis.
  • You should exercise caution when you are over 65, if you smoke, if your liver is calcified, if you have a history of GI problems, advanced hepatic diseases, coagulopathy, coagulopathy, and combination therapy with anticoagulants, corticosteroids, and/or aspirin, or selective serotonin reuptake inhibiters.
  • To minimize GI side effects, it is important to use the lowest effective dose and for the shortest time. This should be consistent with the individual patient's goals.
  • Patients at high risk should consider alternate treatment options.
  • Due to the possibility of GI ulcers, it is recommended that NSAIDs be used with aspirin.
• Hematologic effects
  • Anemia can result from prolonged NSAID treatment.
  • Extended bleeding times, decreased platelet adhesion and increased aggregation can be caused by NSAIDs.
  • Patients with coagulation disorders and those taking anticoagulants need to be closely monitored.
  • Rarely, severe blood dyscrasias can be caused by NSAIDs (e.g., agranulocytosis or thrombocytopenia),
• Hepatic effects
  • Patients with abnormal LFT must be closely monitored due to the possibility of transaminitis.
  • NSAIDs can cause life-threatening liver reactions (eg, fulminant Hepatitis, severe hepatic disease, or hepatic failure).
  • Therapy should be stopped if there are any signs or symptoms that indicate liver disease.
• Hyperkalemia:
  • Due to the increased risk for hyperkalemia in older age, DM and renal disease, as well as concomitant use other agents that can cause hyperkalemia (eg ACE inhibitor), it is important to monitor potassium closely.
• Effects on the renal system:
  • NSAIDs can cause decreased renal blood flow and dose-dependent decreases of prostaglandin synthesis, which can lead to renal insufficiency.
  • Dehydration, hypovolemia and heart failure increase the risk of kidney toxicity in the elderly, as well as those who are taking diuretics or ACE inhibitors.
  • Patients should be properly hydrated before starting treatment.
  • Chronic therapy can be used to treat renal papillary necrosis or other injuries.
• Reactions to skin:
  • Exfoliative dermatitis and Stevens-Johnson Syndrome can lead to life-threatening reactions.
  • The first sign of skin rash or any other hypersensitivity should prompt you to stop therapy.
• Aseptic meningitis
  • Patients with systemic lupus, mixed connective tissue disorders and patients with systemic-lupus erythematosus are at greater risk for aseptic meningitis.
• Asthma
  • Patients with asthma that is aspirin-sensitive should not take diclofenac. If this happens, severe and potentially fatal bronchospasm can occur.
  • Patients with other forms or asthma should be cautious.
• Coronary bypass surgery for coronary artery bypass: [US Boxed Warn]
  • Therapy is not recommended in the context of (CABG surgery) due to the possibility of MI or stroke.
• Hepatic impairment
  • Patients with hepatic impairment should exercise caution and reduce their dose.
  • Patients with advanced hepatic diseases are more likely to experience GI bleeding from NSAIDs than those without.
• Renal impairment
  • If the risks of worsening renal function are not outweighed by the benefits, avoid use.
  • The injection should not be given to patients suffering from moderate or severe renal impairment.
  • NSAIDs should not be used in patients who have moderate or severe renal impairment during the perioperative period, and are at high risk of volume loss.

 

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Monitoring parameters:

• BP
• CBC
• LFTs
• RFTs
• chemistry profile
• weight gain, edema
• occult blood loss
• GI effects (abdominal pain, bleeding, dyspepsia)
• mental confusion, disorientation
• Any bleeding, bruising

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How to administer Diclofenac?

Injection:

• Administer as an intravenous bolus over 15 seconds.

Oral:

• Delayed- or extended-release tablets should not be crushed.
• Immediate-release formulations can be given with food or milk to avoid gastric distress.

Cambia, Zorvolex:

• Administering with food may cause a reduction in effectiveness.

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Mechanism of action of Diclofenac (Diclo, Voren):

• Diclofenac is an antipyretic, analgesic and anti-inflammatory drug.
• It inhibits cyclooxygenase-1 (COX-1) enzymes, which causes decreased formation of prostaglandin precursors.
• Others that have been suggested as contributing to the anti-inflammatory effects are decreased proinflammatory cytokine level, chemotaxis inhibition and lymphocyte activity alteration.
• They also inhibit neutrophil activation.

Absorption: Oral:

• 50% (systemically available).

Protein binding:

• >99% (primarily to albumin).

Metabolism:

• Hepatic; undergoes first-pass metabolism; forms several metabolites (1 with weak activity).

Bioavailability:

• 55%.

Half-life elimination:

• Oral: 2 hours; ~1 hour (liquid-filled capsule [Zipsor])
• Injection: 1.4 hours.

Time to peak serum concentration:

• Note: Fasted values reported for oral products; may be delayed with food.
• Cambia: ~0.25 hours
• Cataflam, Zorvolex: ~1 hour
• Zipsor: ~0.47 ± 0.17 hour
• Injection: ~5 minutes
• Delayed-release tablets (diclofenac sodium): 2.3 hours
• Extended-release Tablets (diclofenac sodium): 5.3 hours

Excretion:

• Urine (~65%);
• Bile (~35%)

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International Brands of Diclofenac:

• Cambia
• Dyloject
• Voltaren-XR
• Zipsor
• Zorvolex
• APO-Diclo
• APO-Diclo Rapide
• APO-Diclo SR
• Cambia
• Diclofenac-50
• DOM-Diclofenac
• NTP-Diclofenac Sodium SR
• NTP-Diclofenac Sodium
• PMS-Diclofenac
• PMS-Diclofenac K
• PMS-Diclofenac-SR
• PRO-Diclo Rapide-50
• SANDOZ Diclofenac
• SANDOZ Diclofenac Rapide
• SANDOZ Diclofenac SR
• TEVA-Diclofenac EC
• TEVA-Diclofenac SR
• TEVA-Diclofenac
• TEVA-Diclofenac-K
• Voltaren
• Voltaren Rapide
• Voltaren SR
• Abitren
• Actifen CR
• Acuflam
• Adiflam
• Allvoran
• Almiral
• Anterin
• Anuva
• Arcanafenac
• Artimed
• Artrites
• Berifen
• Betaren
• Bi Su Fu
• Bioran
• Catafast
• Catafen
• Cataflam
• Cataflam D
• Cataflam Drops
• Catanac
• Catas
• Cencenac
• Clofec
• Clofen
• Clofen Retard
• Clofenex-50
• Clonac
• Cordralan
• Curafen
• D-Fiam
• Declophen
• Depain
• Diclac
• Diclax SR
• Dicloas
• Diclobene
• Diclofen
• Diclofen Cremogel
• Diclofenac
• Dicloflam
• Diclomax
• Diclon
• Diclosan SR
• Diclosian
• Diclowal
• Dicofen
• Difelene
• Difena
• Difene
• Diflosid
• Dioxaflex
• Dioxaflox
• Disflam
• Divoltar
• Divon CR
• Doflex
• Dolotren
• Dolpasse
• Dosanac
• E
• Ecofenac
• Epifenac
• Eurofenac
• Fenac
• Flamquit
• Flector
• Flexagen
• Flogozan
• Fortfen SR
• Inac
• Inflamac
• Inflanac
• Joflam
• Kadiflam
• Lesflam
• Maxit
• Merflam
• Mioclof
• Mobifen
• Monoflam
• Neodolpasse
• Nepenthe
• Novarin
• Ofenac
• Olfen
• Olfen-75 SR
• Osteoflam
• Panamor
• Potaflam
• Profenac
• Raost
• Remafen
• Remethan
• Ren
• Rewodina
• Rhemofenax
• Sefnac
• Soproxen
• Swiss Relief Dual Release
• Taks
• Troflam
• Tromax
• Ultrafen
• Vartelon
• Vesconac
• Vivian
• Volcan
• Voldic
• Voldick-K
• Volna-K
• Volta
• Voltaflam
• Voltaflex
• Voltaren
• Voltaren Acti-Go
• Voltaren Dolo
• Voltaren Rapid
• Voltaren SR
• Voltarene
• Voltarol
• Voltfast
• Voltine
• Volton-CR
• Voren
• Votalin
• Votan
• Votan SR
• Votrex
• Voveran
• Vurdon
• Yingtaiqing
• Yuren
• Zobid
• Zobid D
• Zolterol
• Zolterol SR

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Diclofenac Brand Names in Pakistan:

Diclofenac Potassium Injection 75 mg
Artonec	Biogenics Pakistan (Pvt) Ltd.

 

Diclofenac Potassium Gel 2 % W/W
Diclomax	Max Pharmaceuticals

 

Diclofenac Potassium Tablets 20 mg
Heumatic-K	Neutro Pharma (Pvt) Ltd.

 

Diclofenac Potassium Tablets 25 mg
Signa	Valor Pharmaceuticals

 

Diclofenac Potassium Tablets 50 mg
Achex	Wise Pharmaceuticals (Pvt) Ltd
Aldal	Alson Pharmaceuticals
Alfakalium	Alfalah Pharma (Pvt) Ltd.
Amdic	Amros Pharmaceuticals.
Amdik	Amros Pharmaceuticals.
Antiflam	Wilshire Laboratories (Pvt) Ltd.
Artimov-K	Barrett Hodgson Pakistan (Pvt) Ltd.
Artinil-K	Global Pharmaceuticals
Avorek	Asian Continental (Pvt) Company
Caflam	Novartis Pharma (Pak) Ltd
Caflam	Novartis Pharma (Pak) Ltd
Carafenacp	Caraway Pharmaceuticals
Catafen	Cibex (Private) Limited
Caveron	Fynk Pharmaceuticals
Clo-Tasium	Gray`S Pharmaceuticals
Clodium-K	Pearl Pharmaceuticals
Clonap	Venture Chemical & Pharmaceuticals (Pvt) Ltd.
Clop	Delux Chemical Industries
Declam	Searle Pakistan (Pvt.) Ltd.
Dectil	Rakaposhi Pharmaceutical (Pvt) Ltd.
Deflam	Consolidated Chemical Laboratories (Pvt) Ltd.
Denum-K	Irza Pharma (Pvt) Ltd.
Denum-K	Irza Pharma (Pvt) Ltd.
Detaflam	Webros Pharmaceuticals
Dfinep	Alliance Pharmaceuticals (Pvt) Ltd.
Dic-P	Shaheen Pharmaceuticals
Dicbro	Albro Pharma
Dick 50	Lloyds Pharmaceuticals
Diclo-P	P.D.H. Pharmaceuticals (Pvt) Ltd.
Diclobron-K	Wellborne Pharmachem And Biologicals
Diclodyn K	Orta Labs. (Pvt) Ltd.
Dicloflam-P	Qureshi Pharma (Pvt) Ltd.
Diclokalium	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Diclomed	Unipharma (Pvt) Ltd.
Diclorep	Sami Pharmaceuticals (Pvt) Ltd.
Diclosaf-P	Saaaf Pharmaceuticals
Diclosel-P	Selmore Agencies
Diclotus K	Lotus Pharmaceuticals (Pvt) Ltd
Diclotus-K	Lotus Pharmaceuticals (Pvt) Ltd
Diclowan-Qa	Nawan Laboratories (Pvt) Ltd.
Diclowise K	Pharmawise Labs. (Pvt) Ltd.
Dicloyan-P	Roryan Pharmaceutical Industries (Pvt) Ltd
Dicop-K	Universal Pharmaceuticals (Pvt) Ltd
Dicowise K	Pharmawise Labs. (Pvt) Ltd.
Dicpot	Star Laboratories (Pvt) Ltd.
Difsom-P	Vega Pharmaceuticals Ltd.
Dikan	Shazals Pharmaceuticals
Dinopen	21st Century Pharmaceuticals Co.
Dolgit	Pakistan Pharmaceutical Products (Pvt) Ltd.
Dolijit	Pakistan Pharmaceutical Products (Pvt) Ltd.
Dolo-K	Bosch Pharmaceuticals (Pvt) Ltd.
Dolowel	Welmark Pharmaceuticals
Dorbid	Hiranis Pharmaceuticals Pvt Ltd
Dp-Med	Medicraft Pharmaceuticals (Pvt) Ltd.
Dyna-K	Akson Pharmaceuticals (Pvt) Ltd.
Eplopot	Epharm Laboratories
Fapa	Caylex Pharmaceuticals (Pvt) Ltd.
Fastaid Plus	Platinum Pharmaceuticals (Pvt.) Ltd.
Fenbar	Usawa Pharmaceuticals
Fendic	Polyfine Chempharma (Pvt) Ltd.
Fenik K	Reko Pharmacal (Pvt) Ltd.
Flamatrol	Zesion Pharmaceutical (Pvt) Ltd
Flexura	Fassgen Pharmaceuticals
Frodic-P	Ferroza International Pharmaceuticals (Pvt) Ltd.
Glif-K	Glitz Pharma
Hi-Nil	Zeb Laboratories
Hondic K	Honig Pharmaceuticals Laboratories
Inflaban	Medera Pharmaceuticals (Pvt) Ltd.
Jfenac-P	Jawa Pharmaceuticals(Pvt) Ltd.
Kafenac	Danas Pharmaceuticals (Pvt) Ltd
Kanic	Bloom Pharmaceuticals (Pvt) Ltd.
Kemipan	Alkemy Pharmaceutical Laboratories (Private) Ltd.
Kenac	Medisave Pharmaceuticals
Kerwel	Cherwel Pharmaceuticals (Pvt) Ltd
Ketagesic	Hygeia Pharmaceuticals
Ketawin	Jinnah Pharmaceuticals
Keygesic	Benson Pharamceuticals.
Klic	Tabros Pharma
Klodic	Nabiqasim Industries (Pvt) Ltd.
Komfort	Tagma Pharma (Pvt) Ltd.
Lopran-P	Lowitt Pharmaceuticals (Pvt) Ltd
Luxafen-K	Unimark Pharmaceuticals
Macdafin	21st Century Pharmaceuticals Co.
Makaid-K	Makson Pharmaceuticals
Marinac-P	Miracle Pharmaceuticals(Pvt) Ltd
Maxit	Hilton Pharma (Pvt) Limited
Mobil-K	Davis Pharmaceutical Laboratories
Moov-K	Biogen Pharma
Mouflam	Macquins International
Move	Silver Oak Corporation.
Muskel	Hamaz Pharmaceutical (Pvt) Ltd.
Nacta	Epla Laboratories (Pvt) Ltd.
Neofenik	Neo Medix
Newdik	Olive Laboratories
Nimatic	Nimrall Laboratories
Nipgesic	Qintar Pharmacuticals
Noaflam	Noa Hemis Pharmaceuticals
Nostif-K	Axis Pharmaceuticals
Obnack	Obsons Pharmaceuticals
Opain	Flow Pharmaceuticals (Pvt) Ltd.
Optel-P	Ideal Pharmaceutical Industries
Ostefen	Saydon Pharmaceutical Industries (Pvt) Ltd.
Osti-P	Bio Pharma
Painless	Wise Pharmaceuticals (Pvt) Ltd
Painnil P	Hansel Pharmacueutical Pvt (Ltd)
Panik	Shrooq Pharmaceuticals
Paplofen-P	P.D.H. Pharmaceuticals (Pvt) Ltd.
Phenpal	Alson Pharmaceuticals
Pofen	Fozan Pharmaceuticals Industriers (Pvt) Ltd
Potadic	Anchor Pharma
Potanic-P	Zinta Pharmaceuticals Industries
Potfenac	Karachi Chemical Industries
Potran	Unexo Labs (Pvt) Ltd.
Potran	Unexo Labs (Pvt) Ltd.
Quikrel	Z-Jans Pharmaceutical (Pvt) Ltd.
Relpain	Well & Well Pharma (Pvt) Ltd
Relsec	Rasco Pharma
Relsec	Rasco Pharma
Rheu-K	Standard Drug Co.
Rheumatin-K	Siza International (Pvt) Ltd.
Ronset	Paramount Pharmaceuticals
Rubor	Usawa Pharmaceuticals
Rubor	Usawa Pharmaceuticals
Rumpo	Everest Pharmaceuticals
Swiso-P	Swiss Pharmaceuticals (Pvt) Ltd.
Syfenac	Vision Pharmacueticals
Syndifen	Syntex Pharmaceuticals
Tuzfen	Obsons Pharmaceuticals
Vaclo-Pot	Valor Pharmaceuticals
Valron-P	Venus Pharma
Valron-P	Venus Pharma
Valron-P	Venus Pharma
Voltaflam	Platinum Pharmaceuticals (Pvt.) Ltd.
Voltec-P	Safe Pharmaceutical (Pvt) Ltd.
Voren-K	Asian Continental (Pvt) Company
Zainex	Sapient Pharma
Zofen-K	Harmann Pharmaceutical Laboratories (Pvt) Ltd.

 

Diclofenac Potassium Tablets 75 mg
Achex	Wise Pharmaceuticals (Pvt) Ltd
Aldal	Alson Pharmaceuticals
Andic-K	Nova Med Pharmaceuticals
Antiflam	Wilshire Laboratories (Pvt) Ltd.
Ardi-K	English Pharmaceuticals Industries
Ardi-K	English Pharmaceuticals Industries
Artimov-K	Barrett Hodgson Pakistan (Pvt) Ltd.
Artinil-K	Global Pharmaceuticals
Beflam	Batala Pharmaceuticals.
Biodic-P	Biorex Pharmaceuticals
Carafenacp	Caraway Pharmaceuticals
Caveron	Fynk Pharmaceuticals
Coromp	Zephyr Pharmatec (Pvt) Ltd.
Dardnil	Delta Pharma (Pvt) Ltd.
Declam	Searle Pakistan (Pvt.) Ltd.
Deltaflam	Webros Pharmaceuticals
Denum	Irza Pharma (Pvt) Ltd.
Denum-K	Irza Pharma (Pvt) Ltd.
Dfinep	Alliance Pharmaceuticals (Pvt) Ltd.
Dic-P	Shaheen Pharmaceuticals
Dicfin	Dr. Raza Pharma (Private) Limited
Diclosaf-P	Saaaf Pharmaceuticals
Diclotus K	Lotus Pharmaceuticals (Pvt) Ltd
Diclotus-K	Lotus Pharmaceuticals (Pvt) Ltd
Diclovis K	Global Pharmaceuticals
Diclowan-P	Swan Pharmaceuticals(Pvt) Ltd
Diclox Plus	Wns Field Pharmaceuticals
Dicsium	Evergreen Pharmaceuticals Pvt Limited
Dif-K	Crown Pharmaceuticals
Dinak	Robins Pharmaceutical Industries
Dipolive	Olive Pharmaceuticals
Dolocalm	Envoy Pharma
Dolowel	Welmark Pharmaceuticals
Eplopot	Epharm Laboratories
Fareop	Lexicon Pharmaceuticals (Pvt) Ltd.
Flexura	Fassgen Pharmaceuticals
Frendik-P	Friends Pharma (Pvt) Ltd
Frisky	Crest Pharmaceuticals
Genek-75	Polyfine Chempharma (Pvt) Ltd.
Glif-K	Glitz Pharma
Inflaban	Medera Pharmaceuticals (Pvt) Ltd.
Kalfen	Candid Pharmaceuticals
Kemipan Plus	Alkemy Pharmaceutical Laboratories (Private) Ltd.
Kenac	Medisave Pharmaceuticals
Ketagesic	Hygeia Pharmaceuticals
Keygesic	Benson Pharamceuticals.
Klic-F	Tabros Pharma
Lofen	Shawan Pharmaceuticals
Makaid-K	Makson Pharmaceuticals
Marinac-P	Miracle Pharmaceuticals(Pvt) Ltd
Maxit	Hilton Pharma (Pvt) Limited
Moov-K	Biogen Pharma
Muskel	Hamaz Pharmaceutical (Pvt) Ltd.
Neofenik	Neo Medix
Noaflam	Noa Hemis Pharmaceuticals
Ostefen	Saydon Pharmaceutical Industries (Pvt) Ltd.
Painless	Wise Pharmaceuticals (Pvt) Ltd
Painogin	Zanctok Pharmaceuticals
Painogin	Zanctok Pharmaceuticals
Phenpal	Alson Pharmaceuticals
Phlodic K	Pearl Pharmaceuticals
Pofen	Fozan Pharmaceuticals Industriers (Pvt) Ltd
Potafin	Goodman International,
Qrelif	Medizan Labs (Pvt) Ltd
Qufen-K	High - Q International
Qufen-K	High - Q International
Regopyrin	Regent Laboratories Ltd.
Relpain	Well & Well Pharma (Pvt) Ltd
Relsec	Rasco Pharma
Reuqin	Qintar Pharmacuticals
Rheu-K	Standard Drug Co.
Rheumatin-K	Siza International (Pvt) Ltd.
Ronac	Rogen Pharmaceuticals
Ronset	Paramount Pharmaceuticals
Rxoflam	Healers Laboratories
Signa	Valor Pharmaceuticals
Sydip	Albro Pharma
Tonek 75	Polyfine Chempharma (Pvt) Ltd.
Unifin	Unison Chemical Works
Vaclo-Pot	Valor Pharmaceuticals
Volden Fort K	Rotex Medica Pakistan (Pvt) Ltd
Voltec-P	Safe Pharmaceutical (Pvt) Ltd.
Zainex	Sapient Pharma
Zofen-K	Harmann Pharmaceutical Laboratories (Pvt) Ltd.

 

Diclofenac Potassium Tablets 100 mg
Artimov-K	Barrett Hodgson Pakistan (Pvt) Ltd.
Catafen	Cibex (Private) Limited
Dp-Med	Medicraft Pharmaceuticals (Pvt) Ltd.
Moven	Shrooq Pharmaceuticals
Noaflam	Noa Hemis Pharmaceuticals
Ronac Sr	Rogen Pharmaceuticals
Voltaflam	Platinum Pharmaceuticals (Pvt.) Ltd.

 

Diclofenac Potassium Tablets SR 100 mg
Artinil-K	Global Pharmaceuticals
Diclosaf-P	Saaaf Pharmaceuticals
Fen-K	Pakheim Internanational Pharma
Mediflam	Mediceena Pharma (Pvt) Ltd.
Voltec-P	Safe Pharmaceutical (Pvt) Ltd.

 

Diclofenac Potassium Caps 50 mg
Ariflam	Aries Pharmaceuticals (Pvt) Ltd
Basocap	Basel Pharmaceuticals
Di-Pot	Cherwel Pharmaceuticals (Pvt) Ltd
Difene	Aries Pharmaceuticals (Pvt) Ltd
Dikpel	Universal Pharmaceuticals (Pvt) Ltd
Dosium	Ferroza International Pharmaceuticals (Pvt) Ltd.
Fllassium-K	Polyfine Chempharma (Pvt) Ltd.
Mifen	Bloom Pharmaceuticals (Pvt) Ltd.
Movom P	Nenza Pharmaceuticals (Pvt) Limited
Naveflam	Navegal Laboratories
Sydasic	Sayyed Pharmaceuticals
Xyklo	Ambrosia Pharmaceuticals
Xyklo	Ambrosia Pharmaceuticals
Ziclopel	Z-Jans Pharmaceutical (Pvt) Ltd.

 

Diclofenac Potassium Capsules 75 mg
Ariflam	Aries Pharmaceuticals (Pvt) Ltd
Arthopot	Genome Pharmaceuticals (Pvt) Ltd
Dicfen-P	Meditech Pharmaceuticals
Difene	Aries Pharmaceuticals (Pvt) Ltd
Engrol	English Pharmaceuticals Industries
Movom P	Nenza Pharmaceuticals (Pvt) Limited
Naveflam	Navegal Laboratories
Olitass	Olive Pharmaceuticals

 

Diclofenac Potassium Capsules 100 mg
Anti-Pain	Medicraft Pharmaceuticals (Pvt) Ltd.
Difene	Aries Pharmaceuticals (Pvt) Ltd
Movom P	Nenza Pharmaceuticals (Pvt) Limited

 

Diclofenac Potassium Capsules SR 100 mg
Ariflam	Aries Pharmaceuticals (Pvt) Ltd

 

Diclofenac Sodium Injection 25 mg/ml
Afnac	Tg Pharma
Aksofenac	Akson Pharmaceuticals (Pvt) Ltd.
Alcasar	Pharmedic (Pvt) Ltd.
Altoron	Helix Pharma (Private) Limited
Anaren	Sharex Laboratories (Pvt.) Ltd.
Anaren	Sharex Laboratories (Pvt.) Ltd.
Ardi	English Pharmaceuticals Industries
Arthron	Spencer Pharma
Artifen	Abbott Laboratories (Pakistan) Limited.
Axflam	Alina Combine Pharmaceuticals (Pvt) Ltd.
Camotaren	Chas. A. Mendoza
Clofnac	Ceicil Laboratories Ltd.
Clofnac	Ceicil Laboratories Ltd.
Cyclofenac	Macquins International
Danum	Irza Pharma (Pvt) Ltd.
Danum	Irza Pharma (Pvt) Ltd.
Deborn	Wellborne Pharmachem And Biologicals
Defina	Mediaims Pharmaceuticals
Dejafin	Zinta Pharmaceuticals Industries
Denum	Irza Pharma (Pvt) Ltd.
Denum	Irza Pharma (Pvt) Ltd.
Diacron	Karachi Pharmaceutical Laboratory
Diclobid	Mass Pharma (Private) Limited
Diclocin	Mediceena Pharma (Pvt) Ltd.
Diclodyn	Orta Labs. (Pvt) Ltd.
Diclofenac	Amros Pharmaceuticals.
Diclofenac Sodium	Haji Medicine Co.
Diclofenac Sodium	Elko Organization (Pvt) Ltd.
Diclogin	Star Laboratories (Pvt) Ltd.
Dicloking	Medicraft Pharmaceuticals (Pvt) Ltd.
Diclomac	Ottoman Pharma
Dicloran	Sami Pharmaceuticals (Pvt) Ltd.
Diclorex	Rex Pharmaceuticals Pakistan
Diclosave	Medisave Pharmaceuticals
Diclovat	Meezab International
Diclowal	Ibl Health Care (Pvt) Ltd
Diclowan	Nawan Laboratories (Pvt) Ltd.
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Dicofen	Glaxosmithkline
Dicofen	Glaxosmithkline
Dicrays	Caraway Pharmaceuticals
Dicsod	Medicaids Pakistan (Pvt) Ltd.
Diflosid	Geofman Pharmaceuticals
Diflosid	Geofman Pharmaceuticals
Diklonat-P	Pliva Pakistan (Pvt) Limited
Dolnot	P.D.H. Pharmaceuticals (Pvt) Ltd.
Doloflam	Pulse Pharmaceuticals
Durum	Elko Organization (Pvt) Ltd.
Dyclo	Indus Pharma (Pvt) Ltd.
Ephanac	Epharm Laboratories
Eurofenac	Ophth-Pharma (Pvt) Ltd.
Fenaclod	Epoch Pharmaceutical
Fendic S	Polyfine Chempharma (Pvt) Ltd.
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Flamex	Werrick Pharmaceuticals
Forgenac	Tread Pharmaceuticals Pvt Ltd
Glif-S	Glitz Pharma
Heumatic	Neutro Pharma (Pvt) Ltd.
Inflamac	Ipram International
Lisodim	Surge Laboratories (Pvt) Ltd.
Lofsim	Z-Jans Pharmaceutical (Pvt) Ltd.
Lonac	Pharmatec Pakistan (Pvt) Ltd.
Magnofenac	Agp (Private) Ltd.
Magnofenac	Agp (Private) Ltd.
Maxit-S	Hilton Pharma (Pvt) Limited
Mb-Diclo	Multinational Buisness Link
Motaar	Standpharm Pakistan (Pvt) Ltd.
Motaar	Standpharm Pakistan (Pvt) Ltd.
Neurofenac	Merck Private Ltd.
Orthofenac	Bosch Pharmaceuticals (Pvt) Ltd.
Ostinac	Global Pharmaceuticals
Painnil	Hansel Pharmacueutical Pvt (Ltd)
Painrest	Mediceena Pharma (Pvt) Ltd.
Painstop	Trigon Pharmaceuticals Pakistan (Pvt) Ltd.
Penfen	Atco Laboratories Limited
Phlogin	Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Progile	Helix Pharma (Private) Limited
Puldol	Pulse Pharmaceuticals
Rapiget	Muller & Phipps Pakistan (Pvt) Ltd.
Remethan	High - Q International
Rheumatin	Siza International (Pvt) Ltd.
Satafenac	Saturn Pharmaceuticals (Pvt) Ltd
Shaltaren	Shifa Laboratories.(Pvt) Ltd.
Sofac	Saffron Pharmaceutical Company
Sofren	Harmann Pharmaceutical Laboratories (Pvt) Ltd.
Spic-Fenic	S. Ejazuddin & Company
Swiso	Swiss Pharmaceuticals (Pvt) Ltd.
Treafen	Treat Pharmaceuticals
Valron	Venus Pharma
Vectra	Fassgen Pharmaceuticals
Voldos	Dosaco Laboratories
Volfen	Saydon Pharmaceutical Industries (Pvt) Ltd.
Volite	Elite Pharma
Volite	Elite Pharma
Voltagesic	Cibex (Private) Limited
Voltral	Novartis Pharma (Pak) Ltd
Voren	Continental Chemical Company (Pvt) Ltd.
Voren	Continental Chemical Company (Pvt) Ltd.
Vurdon	R.Y. International
Woodtran	Lawrence Pharma

 

Diclofenac Sodium Injection 75 mg/2ml
Deborn-L	Wellborne Pharmachem And Biologicals

 

Diclofenac Sodium Injection 75 mg/3ml
Defnac	Searle Pakistan (Pvt.) Ltd.
Dicloscot	Scotmann Pharmaceuticals
Difam	Bosch Pharmaceuticals (Pvt) Ltd.
Mobikare	Barrett Hodgson Pakistan (Pvt) Ltd.

 

Diclofenac Sodium Injection (IV) 25 mg/ml
Fendol	Crest Pharmaceuticals

 

Diclofenac Sodium Drops 0.1 % W/V
Difnac-E	Panacea Pharmaceuticals

 

Diclofenac Sodium Eye Drops 0.1 % W/V
Altoron Eye Drops	Helix Pharma (Private) Limited
Artinil	Global Pharmaceuticals
Diclocin	Mediceena Pharma (Pvt) Ltd.
Diclomin	The Schazoo Laboratories Ltd.
Diclon	Atco Laboratories Limited
Diclotek	Innvotek Pharmaceuticals
Dicny	Jaens Pharma
Difen-Stulln Ud	Haroon Brothers
Dofnac	Ethical Laboratories (Pvt) Ltd.
Fendic S	Polyfine Chempharma (Pvt) Ltd.
Konac	Remington Pharmaceutical Industries (Pvt) Ltd.
Naclof	Novartis Pharma (Pak) Ltd
Nozin	Fastel Lab
Oclonac	Barrett Hodgson Pakistan (Pvt) Ltd.
Ocufenac	Farmigea Pak (Pvt) Ltd.
Ophdic	Reko Pharmacal (Pvt) Ltd.
Ophth-Diclofen	Ophth-Pharma (Pvt) Ltd.
Orthofenac	Bosch Pharmaceuticals (Pvt) Ltd.
Painrest	Mediceena Pharma (Pvt) Ltd.

 

Diclofenac Sodium Ear Drops 0.1 % W/V
Difsom	Vega Pharmaceuticals Ltd.

 

Diclofenac Sodium Gel 10 mg
Santofen	Sante (Pvt) Limited

 

Diclofenac Sodium Gel 1 % W/W
Arthosure	Medisure Laboratories Pakistan (Pvt.) Ltd.
Artifen Topical	Abbott Laboratories (Pakistan) Limited.
Artinil-K	Global Pharmaceuticals
Artinil-K Topical	Global Pharmaceuticals
Defloquin	Everest Pharmaceuticals
Diclofast	Medisearch Pharmacal(Pvt) Ltd
Diclofena	Islamabad Pharmaceutical Products
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Disof	Reliance Pharma
Ephanac	Epharm Laboratories
Fenodic	Trigon Pharmaceuticals Pakistan (Pvt) Ltd.
Fiedic	Friends Pharma (Pvt) Ltd
Flaren	Epla Laboratories (Pvt) Ltd.
Inflamac	Ipram International
Mobikare	Barrett Hodgson Pakistan (Pvt) Ltd.
Motiv	Biogen Pharma
Moven	Shrooq Pharmaceuticals
Pain-X	Panacea Pharmaceuticals
Rapiget	Muller & Phipps Pakistan (Pvt) Ltd.
Rheumagel	Tg Pharma
Sofac	Saffron Pharmaceutical Company
Sonifac	Rex Pharmaceuticals Pakistan
Valron	Venus Pharma
Voltec	Safe Pharmaceutical (Pvt) Ltd.
Voltral Emulgel	Novartis Pharma (Pak) Ltd
Voltral Emulgel	Novartis Pharma (Pak) Ltd
Voltral Emulgel	Novartis Pharma (Pak) Ltd
Vurdon	R.Y. International
Xinia	Nimrall Laboratories
Zalin	Tagma Pharma (Pvt) Ltd.

 

Diclofenac Sodium Gel 2 % W/W
Diclofenac	Safina Pharma (Pvt) Ltd
Dicloprime Gel	Prime Labs. (Pvt) Ltd.
Motaar	Standpharm Pakistan (Pvt) Ltd.

 

Diclofenac SSodium dium Tablets 25 mg
Alfafenac	Alfalah Pharma (Pvt) Ltd.
Altoron	Helix Pharma (Private) Limited
Artifen	Abbott Laboratories (Pakistan) Limited.
Diacron	Karachi Pharmaceutical Laboratory
Diacron	Karachi Pharmaceutical Laboratory
Dicloking	Medicraft Pharmaceuticals (Pvt) Ltd.
Diclotab	Wilshire Laboratories (Pvt) Ltd.
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Dicsod	Medicaids Pakistan (Pvt) Ltd.
Diflosid	Geofman Pharmaceuticals
Dyclo	Indus Pharma (Pvt) Ltd.
Lonac	Pharmatec Pakistan (Pvt) Ltd.
Rheumatin	Siza International (Pvt) Ltd.
Sonal	Pharmacare Laboratories (Pvt) Ltd.
Ufenac	Valor Pharmaceuticals
Ultrafen	Bex Pharma (Pvt) Ltd.
Volfen	Saydon Pharmaceutical Industries (Pvt) Ltd.
Voltral	Novartis Pharma (Pak) Ltd
Voren	Continental Chemical Company (Pvt) Ltd.

 

Diclofenac Sodium Tablets 50 mg
Accred	Albro Pharma
Aksofenac	Akson Pharmaceuticals (Pvt) Ltd.
Aleve	Aries Pharmaceuticals (Pvt) Ltd
Alfafenac	Alfalah Pharma (Pvt) Ltd.
Anac	Rasco Pharma
Anac	Rasco Pharma
Anaren	Sharex Laboratories (Pvt.) Ltd.
Anaren	Sharex Laboratories (Pvt.) Ltd.
Anaren	Sharex Laboratories (Pvt.) Ltd.
Annuva	Novartis Pharma (Pak) Ltd
Araam	Alliance Pharmaceuticals (Pvt) Ltd.
Ardfenac	Ardin Pharmaceuticals
Arnil	Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Arthonil	Batala Pharmaceuticals.
Arthonil	Batala Pharmaceuticals.
Arthron	Spencer Pharma
Arthrotop	Panacea Pharmaceuticals
Artifen	Abbott Laboratories (Pakistan) Limited.
Atcora	Caylex Pharmaceuticals (Pvt) Ltd.
Axflam	Alina Combine Pharmaceuticals (Pvt) Ltd.
Biodic	Biorex Pharmaceuticals
Camotaren	Chas. A. Mendoza
Clodium	Pearl Pharmaceuticals
Clofenac	Medera Pharmaceuticals (Pvt) Ltd.
Cloran-S	Hizat Pharmaceutical Industries (Pvt) Ltd.
Cyclofen	Danas Pharmaceuticals (Pvt) Ltd
Cyclofenac	Macquins International
Daltran	Umersons
Danotech	Danas Pharmaceuticals (Pvt) Ltd
Davitran	Davis Pharmaceutical Laboratories
Deborn	Wellborne Pharmachem And Biologicals
Defnac	Searle Pakistan (Pvt.) Ltd.
Dejafen-S	Zinta Pharmaceuticals Industries
Deker	Lloyds Pharmaceuticals
Delfenac	Delta Pharma (Pvt) Ltd.
Demsun	Lexicon Pharmaceuticals (Pvt) Ltd.
Denum	Irza Pharma (Pvt) Ltd.
Denum	Irza Pharma (Pvt) Ltd.
Depogen	Silver Oak Corporation.
Dewis	Wise Pharmaceuticals (Pvt) Ltd
Dianic	Nova Med Pharmaceuticals
Dic	Shazals Pharmaceuticals
Dic-50	Zephyr Pharmatec (Pvt) Ltd.
Dic-S	Shaheen Agencies
Dicahit	Unipharma (Pvt) Ltd.
Diclac	Paramount Pharmaceuticals
Diclobid	Mass Pharma (Private) Limited
Diclodium	Zephyr Pharmatec (Pvt) Ltd.
Diclodyn	Orta Labs. (Pvt) Ltd.
Diclofaz	Fozan Pharmaceuticals Industriers (Pvt) Ltd
Diclofen	Karachi Chemical Industries
Diclofenac Sodium	Amros Pharmaceuticals.
Diclogin	Star Laboratories (Pvt) Ltd.
Diclogray	Gray`S Pharmaceuticals
Diclok	Xenon Pharmaceuticals (Pvt) Ltd.
Dicloking	Medicraft Pharmaceuticals (Pvt) Ltd.
Diclomac	Ottoman Pharma
Diclopulse	Pulse Pharmaceuticals
Dicloradvan	Advanced Pharmaceuticals
Dicloran	Sami Pharmaceuticals (Pvt) Ltd.
Diclosaf	Saaaf Pharmaceuticals
Diclosak	Hamaz Pharmaceutical (Pvt) Ltd.
Diclosave	Medisave Pharmaceuticals
Dicloscot	Scotmann Pharmaceuticals
Dicloscot	Scotmann Pharmaceuticals
Diclotab	Wilshire Laboratories (Pvt) Ltd.
Diclovat	Meezab International
Diclowal	Ibl Health Care (Pvt) Ltd
Diclowan	Nawan Laboratories (Pvt) Ltd.
Diclox	Wns Field Pharmaceuticals
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Dicofen	Glaxosmithkline
Dicowise	Pharmawise Labs. (Pvt) Ltd.
Dicsod	Medicaids Pakistan (Pvt) Ltd.
Dicsodim	Benson Pharamceuticals.
Dicsodim	Benson Pharamceuticals.
Dicsonen	Nenza Pharmaceuticals (Pvt) Limited
Diflosid	Geofman Pharmaceuticals
Diflosid	Geofman Pharmaceuticals
Diklonat-P	Pliva Pakistan (Pvt) Limited
Dilon	Zanctok Pharmaceuticals
Dixie	Robins Pharmaceutical Industries
Dolnot	P.D.H. Pharmaceuticals (Pvt) Ltd.
Doloflam	Pulse Pharmaceuticals
Doltran	Progressive Laboratories
Doltran	Progressive Laboratories
Ds-50	Dr. Raza Pharma (Private) Limited
Durafin	Ideal Pharmaceutical Industries
Dyclo	Indus Pharma (Pvt) Ltd.
Dyclo	Indus Pharma (Pvt) Ltd.
Dyclo-P	Indus Pharma (Pvt) Ltd.
Ephanac	Epharm Laboratories
Ephanac	Epharm Laboratories
Fastaid	Platinum Pharmaceuticals (Pvt.) Ltd.
Fastaid-R	Platinum Pharmaceuticals (Pvt.) Ltd.
Fen-S	Pakheim Internanational Pharma
Fenaclod	Epoch Pharmaceutical
Fenaclod	Epoch Pharmaceutical
Fenadium	Sayyed Pharmaceuticals
Fendol	Crest Pharmaceuticals
Ficloran	Flow Pharmaceuticals (Pvt) Ltd.
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Flamex	Werrick Pharmaceuticals
Flaren	Epla Laboratories (Pvt) Ltd.
Frendik-S	Friends Pharma (Pvt) Ltd
G-Ron	Qintar Pharmacuticals
Gl-Ron	Qintar Pharmacuticals
Glen	Jafson Pharmaceuticals (Pvt) Ltd.
Heclofen	Shawan Pharmaceuticals
Heltron	Heal Pharmaceuticals Pvt Ltd
Hondic	Honig Pharmaceuticals Laboratories
Inflex	Maple Pharmaceuticals (Pvt) Ltd
Instaren	Helicon Pharmaceutek Pakistan (Pvt) Ltd.
Jfenac	Jawa Pharmaceuticals(Pvt) Ltd.
Jiclofen-S	Jinnah Pharmaceuticals
Kaldic	Mass Pharma (Private) Limited
Karmel	Ferroza International Pharmaceuticals (Pvt) Ltd.
Kesiflam	Karachi Chemical Industries
Linzac	Linz Pharmaceuticals (Pvt) Ltd.
Lisodim	Surge Laboratories (Pvt) Ltd.
Lodic	Lotus Pharmaceuticals (Pvt) Ltd
Lofsim	Z-Jans Pharmaceutical (Pvt) Ltd.
Lonac	Pharmatec Pakistan (Pvt) Ltd.
Lopran-S	Lowitt Pharmaceuticals (Pvt) Ltd
Lotto	Wilshire Laboratories (Pvt) Ltd.
Lotto D	Wilshire Laboratories (Pvt) Ltd.
Magnofenac	Agp (Private) Ltd.
Magnofenac	Agp (Private) Ltd.
Makaid	Makson Pharmaceuticals
Marinac-S	Miracle Pharmaceuticals(Pvt) Ltd
Matic	Libra Pharmaceuticals (Pvt) Ltd
Mb-Diclo	Multinational Buisness Link
Mecdafin	21st Century Pharmaceuticals Co.
Medifenac Tablet	Medicon Pharmaceuticals Industries (Pvt) Ltd
Mediflam	Mediceena Pharma (Pvt) Ltd.
Megafenac	Mega Pharmaceuticals (Pvt) Ltd
Motaar	Standpharm Pakistan (Pvt) Ltd.
Motifive	Zesion Pharmaceutical (Pvt) Ltd
Motiv	Biogen Pharma
Nadium	Nexus Pharma (Pvt) Ltd
Natrium	Medisynth Pharmaceuticals
Neclof	Pakistan Pharmaceutical Products (Pvt) Ltd.
Noadic	Noa Hemis Pharmaceuticals
Noak	Raazee Theraputics (Pvt) Ltd.
Noltren	Medipak Limited
Novotran	Krka-Pak Pharmaceutical & Chemical Works
Nozin	Fastel Lab
Oberon Forte	Eros Pharmaceuticals
Oberon Forte	Eros Pharmaceuticals
Oblonec	Obsons Pharmaceuticals
Oblonec	Obsons Pharmaceuticals
Odic	Rehmat Pharma
Olifen	Olive Laboratories
Orthofenac	Bosch Pharmaceuticals (Pvt) Ltd.
Orthonil	Genera Pharmaceuticals
Osteonac	Vision 2000 Plus
Ottofenac	Ottoman Pharma
Pain-Aid Plus	Scotmann Pharmaceuticals
Painnil	Hansel Pharmacueutical Pvt (Ltd)
Painrest	Mediceena Pharma (Pvt) Ltd.
Panslay	Getz Pharma Pakistan (Pvt) Ltd.
Penfen	Atco Laboratories Limited
Phonac	Hamaz Pharmaceutical (Pvt) Ltd.
Progile	Helix Pharma (Private) Limited
Pronic	Biogen Pharma
Puldol	Pulse Pharmaceuticals
Qufen	High - Q International
Rakafen	Rakaposhi Pharmaceutical (Pvt) Ltd.
Rapiget	Muller & Phipps Pakistan (Pvt) Ltd.
Raxonac	Medicaux Healthcare
Remethan	High - Q International
Rheudic	Standard Drug Co.
Rheumagel-50	Tg Pharma
Rheumatin	Siza International (Pvt) Ltd.
Rheuyan	Roryan Pharmaceutical Industries (Pvt) Ltd
Rodic	Rock Pharmaceuticals
Rumso	Everest Pharmaceuticals
Safe-T	Albro Pharma
Samotec-50	Unison Chemical Works
Sofac	Saffron Pharmaceutical Company
Sofren	Harmann Pharmaceutical Laboratories (Pvt) Ltd.
Sonal	Pharmacare Laboratories (Pvt) Ltd.
Spon-K	Davis Pharmaceutical Laboratories
Stopan	Phar-Man Laboratories
Swiso	Swiss Pharmaceuticals (Pvt) Ltd.
Teknofenac	Hygeia Pharmaceuticals
Tylofenac	Don Valley Pharmaceuticals (Pvt) Ltd.
U-Tran	Unexo Labs (Pvt) Ltd.
U-Tran	Unexo Labs (Pvt) Ltd.
Ufenac	Valor Pharmaceuticals
Ultrafen	Bex Pharma (Pvt) Ltd.
Valoron	Bloom Pharmaceuticals (Pvt) Ltd.
Valoron	Bloom Pharmaceuticals (Pvt) Ltd.
Visodic	Global Pharmaceuticals
Vodim	Macquins International
Volden Fort	Rotex Medica Pakistan (Pvt) Ltd
Voldos	Dosaco Laboratories
Volfen	Saydon Pharmaceutical Industries (Pvt) Ltd.
Volmax	Bio Pharma
Volnac	Semos Pharmaceuticals (Pvt) Ltd.
Voltab	Medifine Laboratories
Voltadex	Medimark International Co.
Voltagesic	Cibex (Private) Limited
Voltral	Novartis Pharma (Pak) Ltd
Voltree	Shazals Pharmaceuticals
Voltrex	Arsons Pharmaceuticals Industries (Pvt) Ltd
Voren	Continental Chemical Company (Pvt) Ltd.
Vurdon	R.Y. International
Vurdon	R.Y. International
Weldic	Ferroza International Pharmaceuticals (Pvt) Ltd.
Wendim	Webros Pharmaceuticals
Wolflam-50	Rayon International
Xany	Flow Pharmaceuticals (Pvt) Ltd.
Yarnil	Medisure Laboratories Pakistan (Pvt.) Ltd.
Zalin	Tagma Pharma (Pvt) Ltd.
Ziclofen-P	Novins International
Zulfenac	Adamjee Pharmaceuticals (Pvt) Ltd.
Zwitter	Wilshire Laboratories (Pvt) Ltd.

 

Diclofenac Sodium Tablets 75 mg
Ardi	English Pharmaceuticals Industries
Arnil	Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Clofenac	Medera Pharmaceuticals (Pvt) Ltd.
Dc-Na	Crown Pharmaceuticals
Defnac	Searle Pakistan (Pvt.) Ltd.
Defnac	Searle Pakistan (Pvt.) Ltd.
Dianic	Nova Med Pharmaceuticals
Dianic	Nova Med Pharmaceuticals
Dicloking	Medicraft Pharmaceuticals (Pvt) Ltd.
Diclox	Wns Field Pharmaceuticals
Difnac	Panacea Pharmaceuticals
Diroxin	Tagma Pharma (Pvt) Ltd.
Dolnot	P.D.H. Pharmaceuticals (Pvt) Ltd.
Fastaid	Platinum Pharmaceuticals (Pvt.) Ltd.
Fenal T	Alson Pharmaceuticals
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Flexy	Crest Pharmaceuticals
Flexy	Crest Pharmaceuticals
Heclofen	Shawan Pharmaceuticals
Lodic	Lotus Pharmaceuticals (Pvt) Ltd
Lodic	Lotus Pharmaceuticals (Pvt) Ltd
Lonac	Pharmatec Pakistan (Pvt) Ltd.
Lotto	Wilshire Laboratories (Pvt) Ltd.
Makaid	Makson Pharmaceuticals
Natwel	Cherwel Pharmaceuticals (Pvt) Ltd
Natwel	Cherwel Pharmaceuticals (Pvt) Ltd
Osteonac	Vision 2000 Plus
Ottofenac	Ottoman Pharma
Ottofenac	Ottoman Pharma
Pain-Aid Plus	Scotmann Pharmaceuticals
Panslay	Getz Pharma Pakistan (Pvt) Ltd.
Pofac	Wns Field Pharmaceuticals
Prodium	Nimrall Laboratories
Prodium	Nimrall Laboratories
Progile	Helix Pharma (Private) Limited
Raxonac	Medicaux Healthcare
Rodic	Rock Pharmaceuticals
Rodic	Rock Pharmaceuticals
Sharp	Mass Pharma (Private) Limited
Sofac	Saffron Pharmaceutical Company
Sonal	Pharmacare Laboratories (Pvt) Ltd.
Synoflam	Fedro Pharmaceutical
Veclofen	Isis Pharmaceutical
Veclofen	Isis Pharmaceutical
Vottsun	Hisun Pharmaceuticals
Zalin	Tagma Pharma (Pvt) Ltd.
Zulfenac	Adamjee Pharmaceuticals (Pvt) Ltd.

 

Diclofenac Sodium Tablets 100 mg
Araam Sr	Alliance Pharmaceuticals (Pvt) Ltd.
D-Sodium	Weather Folds Pharmaceuticals
Dc-Na	Crown Pharmaceuticals
Dicium	Navegal Laboratories
Dicloasia	Medera Pharmaceuticals (Pvt) Ltd.
Diclosaf	Saaaf Pharmaceuticals
Diclowan Sr	Swan Pharmaceuticals(Pvt) Ltd
Diclozan Sr	Medizan Labs (Pvt) Ltd
Dilon Sr	Zanctok Pharmaceuticals
Dycloxan-Sr	Genome Pharmaceuticals (Pvt) Ltd
Dyosal Sr	Universal Pharmaceuticals (Pvt) Ltd
Ephanac Sr	Epharm Laboratories
Farclodium Sr	Farmaceutics International
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Marinac	Miracle Pharmaceuticals(Pvt) Ltd
Rheudic	Standard Drug Co.
Rodic Sr Sr	Rock Pharmaceuticals
Sidilive Sr Sr	Olive Pharmaceuticals
Veclofen Sr	Isis Pharmaceutical
Vectra Sr	Fassgen Pharmaceuticals
Volden Fort	Rotex Medica Pakistan (Pvt) Ltd
Voltex Sr	Sapient Pharma
Voren-Sr	Asian Continental (Pvt) Company

 

Diclofenac Sodium Tablets SR 100 mg
Alfafenac	Alfalah Pharma (Pvt) Ltd.
Ardfenac	Ardin Pharmaceuticals
Axflam	Alina Combine Pharmaceuticals (Pvt) Ltd.
Defnac	Searle Pakistan (Pvt.) Ltd.
Dewis	Wise Pharmaceuticals (Pvt) Ltd
Diclobid	Mass Pharma (Private) Limited
Diclofaz	Fozan Pharmaceuticals Industriers (Pvt) Ltd
Diclogray	Gray`S Pharmaceuticals
Diclomac	Ottoman Pharma
Diclopulse	Pulse Pharmaceuticals
Dicloran	Sami Pharmaceuticals (Pvt) Ltd.
Diclosave	Medisave Pharmaceuticals
Dicloscost-Xr	Scotmann Pharmaceuticals
Dicloscot-Xr	Seagul Surgical Cotton
Diclox	Wns Field Pharmaceuticals
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Diclozaf	Zafa Pharmaceutical Laboratories (Pvt) Ltd.
Dicsodim	Benson Pharamceuticals.
Diklonat-P	Pliva Pakistan (Pvt) Limited
Doloflam	Pulse Pharmaceuticals
Dyclo	Indus Pharma (Pvt) Ltd.
Fastaid	Platinum Pharmaceuticals (Pvt.) Ltd.
Fenart	Shrooq Pharmaceuticals
Fist	Shaigan Pharmaceuticals (Pvt) Ltd
Flamex	Werrick Pharmaceuticals
Instaren	Helicon Pharmaceutek Pakistan (Pvt) Ltd.
Kaldic	Mass Pharma (Private) Limited
Linzac	Linz Pharmaceuticals (Pvt) Ltd.
Lisodim	Surge Laboratories (Pvt) Ltd.
Lonac	Pharmatec Pakistan (Pvt) Ltd.
Lopran-Sr	Lowitt Pharmaceuticals (Pvt) Ltd
Makaid	Makson Pharmaceuticals
Matic	Libra Pharmaceuticals (Pvt) Ltd
Mb-Diclo	Multinational Buisness Link
Motaar	Standpharm Pakistan (Pvt) Ltd.
Navidic	Global Pharmaceuticals
Neclof	Pakistan Pharmaceutical Products (Pvt) Ltd.
Noadic	Noa Hemis Pharmaceuticals
Orthofenac	Bosch Pharmaceuticals (Pvt) Ltd.
Painrest	Mediceena Pharma (Pvt) Ltd.
Puldol	Pulse Pharmaceuticals
Remethan-R	High - Q International
Rheumatin	Siza International (Pvt) Ltd.
Rheuyan	Roryan Pharmaceutical Industries (Pvt) Ltd
Sofac	Saffron Pharmaceutical Company
Swiso	Swiss Pharmaceuticals (Pvt) Ltd.
Ufenac	Valor Pharmaceuticals
Volfen	Saydon Pharmaceutical Industries (Pvt) Ltd.
Volmax	Bio Pharma
Voltex	Sapient Pharma
Voltral	Novartis Pharma (Pak) Ltd
Voveron	Fynk Pharmaceuticals
Vurdon	R.Y. International
Vurdon	R.Y. International

 

Diclofenac Sodium Capsules 50 mg
Amfac	Ambrosia Pharmaceuticals
Aramfen	Basel Pharmaceuticals
Artonec	Biogenics Pakistan (Pvt) Ltd.
Cloree	Flow Pharmaceuticals (Pvt) Ltd.
D-Cap	English Pharmaceuticals Industries
Dicloadvan	Advanced Pharmaceuticals
Dicloadvan	Advanced Pharmaceuticals
Dicloap	Ottoman Pharma
Diclogesic	Wilsons Pharmaceuticals
Dicloras	Rasco Pharma
Dicloscot	Scotmann Pharmaceuticals
Dicloyan-S	Roryan Pharmaceutical Industries (Pvt) Ltd
Dicorum	Bloom Pharmaceuticals (Pvt) Ltd.
Dissium	Rock Pharmaceuticals
Dyclo Gr	Indus Pharma (Pvt) Ltd.
Dyclo Gr	Indus Pharma (Pvt) Ltd.
Dycnom	Genome Pharmaceuticals (Pvt) Ltd
Fenal	Alson Pharmaceuticals
Finflex	Fedro Pharmaceutical
Hegen	Healers Laboratories
Jorwel	Medicraft Pharmaceuticals (Pvt) Ltd.
Lifdic	Goodman Laboratories
Lotofenac	Lotus Pharmaceuticals (Pvt) Ltd
Mobikare	Barrett Hodgson Pakistan (Pvt) Ltd.
Mobikare	Barrett Hodgson Pakistan (Pvt) Ltd.
Neurofenac	Merck Private Ltd.
Phlodic	Pearl Pharmaceuticals
Phlogin	Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Saldic	Universal Pharmaceuticals (Pvt) Ltd
Simfenic	Simz Pharmaceuticals
Triclo	Trison Research Laboratories (Pvt) Ltd
Triclo-K	Trison Research Laboratories (Pvt) Ltd
Velfenac	Well & Well Pharma (Pvt) Ltd
Volfenac	Aries Pharmaceuticals (Pvt) Ltd
Voren	Continental Chemical Company (Pvt) Ltd.
Zeedic	Z-Jans Pharmaceutical (Pvt) Ltd.
Ziclofen-S	Novins International
Zwitter	Wilshire Laboratories (Pvt) Ltd.

 

Diclofenac Sodium Capsules 75 mg
Aramfen	Basel Pharmaceuticals
Dicloap	Ottoman Pharma
Dicloyan-S	Roryan Pharmaceutical Industries (Pvt) Ltd
Fenal	Alson Pharmaceuticals
Jorwel	Medicraft Pharmaceuticals (Pvt) Ltd.
Mobikare Dr	Barrett Hodgson Pakistan (Pvt) Ltd.
Triclo	Trison Research Laboratories (Pvt) Ltd
Triclo-K	Trison Research Laboratories (Pvt) Ltd
Volfenac	Aries Pharmaceuticals (Pvt) Ltd
Ziclofen-Dr	Novins International
Zwitter	Wilshire Laboratories (Pvt) Ltd.

 

Diclofenac Sodium Capsules 100 mg
Anifen	Medera Pharmaceuticals (Pvt) Ltd.
Biodic	Biorex Pharmaceuticals
Biodic Sr	Biorex Pharmaceuticals
Diclowan Sr	Swan Pharmaceuticals(Pvt) Ltd
Dicloyan-S	Roryan Pharmaceutical Industries (Pvt) Ltd
Dycnom	Genome Pharmaceuticals (Pvt) Ltd
Fenum Sr	Panacea Pharmaceuticals
Hi-Nil Sr	Zeb Laboratories
Jorwel	Medicraft Pharmaceuticals (Pvt) Ltd.
Lotofenac Sr Sr	Lotus Pharmaceuticals (Pvt) Ltd
Natan	Evergreen Pharmaceuticals Pvt Limited
Olisod Sr	Olive Pharmaceuticals
Phlodic	Pearl Pharmaceuticals
Phlonac Sr	Max Pharmaceuticals
Phlosar	Goodman International,
Volfenac	Aries Pharmaceuticals (Pvt) Ltd

 

Diclofenac Sodium Capsules SR 50 mg
Lotofenac	Lotus Pharmaceuticals (Pvt) Ltd

 

Diclofenac Sodium Capsules SR 100 mg
Artonec	Biogenics Pakistan (Pvt) Ltd.
Diagesic Plus	Wilsons Pharmaceuticals
Dicloadvan	Advanced Pharmaceuticals
Diclogesic	Wilsons Pharmaceuticals
Dicloras	Rasco Pharma
Flamex	Werrick Pharmaceuticals
Lotofenac	Lotus Pharmaceuticals (Pvt) Ltd
Med-Diclo	Meditech Pharmaceuticals
Mobikare	Barrett Hodgson Pakistan (Pvt) Ltd.
Mobikare	Barrett Hodgson Pakistan (Pvt) Ltd.
Phlogin	Brookes Pharmaceutical Laboratories (Pak.) Ltd.
Triclo	Trison Research Laboratories (Pvt) Ltd
Xinia	Nimrall Laboratories
Ziclofen	Novins International

 

Diclofenac Sodium Suppositories 25 mg
Voltral Suppos	Novartis Pharma (Pak) Ltd

 

Diclofenac Sodium Suppositories 50 mg
Ultrafen	Bex Pharma (Pvt) Ltd.

 

Diclofenac Sodium Suppositories 100 mg
Voltral Suppos	Novartis Pharma (Pak) Ltd

 

Diclofenac Sodium Suppositories 12.5 mg
Ultrafen	Bex Pharma (Pvt) Ltd.