If you’re among the millions struggling with dry, gritty, or burning eyes, a new FDA-approved treatment offers hope. TRYPTYR® (acoltremon ophthalmic solution) 0.003% is breaking ground in dry eye management. Let’s break down what makes it unique and how it could help you.  

What is TRYPTYR?  

TRYPTYR is a prescription eye drop approved in 2025 for treating the signs and symptoms of dry eye disease. Its active ingredient, acoltremon, works differently than artificial tears or anti-inflammatory drops. Instead, it targets your eyes’ natural tear-production system.  

How Does It Work?  

TRYPTYR activates TRPM8 thermoreceptors – cold-sensing proteins on your eye’s surface. This triggers your trigeminal nerve to ramp up basal tear production. Simply put: it tells your eyes to make more real tears, addressing dryness at its source.  

Key Benefits of TRYPTYR Backed by Science

Two major studies (COMET-2 and COMET-3) proved TRYPTYR’s effectiveness:  

• 42–53% of patients saw tear production increase by ≥10 mm after just 14 days.  
• Results were 3–4× better than placebo and lasted through 90 days of use.  

How to Use Tryptyr Ophthalmic Solution?  

- Dosage: 1 drop in each eye, twice daily (morning and night, 12 hours apart).
- Vial Type: Single-use preservative-free vials (no risk of contamination).  
- Critical Steps:

• Wash hands first.
• Don’t touch the vial tip to your eye or any surface.  
• Remove contacts before applying – wait 15 mins to reinsert.  
• If using other eye drops, space them 5+ minutes apart.  

Possible Side Effects

The most common issue is temporary eye pain at application (reported by 50% in trials). Less than 1% stopped treatment due to stinging.  

Special Considerations  

• Pregnancy/Lactation:
  • Low systemic absorption, but consult your doctor.  
• Children:
  • Not studied in under-18s.  
• Seniors:
  • Safe for older adults.  

Storage & Handling  

- Unopened: Refrigerate (36–46°F / 2–8°C).  
- Opened: Can store at room temp (36–77°F / 2–25°C) for up to 30 days.  
- After opening foil pouch: Use vials within 7 days.

Patient Tips from the Label  

- One vial = both eyes. Discard immediately after use.  
- If you miss a dose: Skip it – don’t double up. Resume at the next scheduled time.  
- Never reuse vials – contamination risk is high.  

The Bottom Line  

TRYPTYR isn’t just another lubricant. By boosting your natural tears, it targets the *cause* of dry eye. While application-site discomfort may occur, its efficacy in restoring tear flow is clinically proven.  

Always consult your ophthalmologist to see if TRYPTYR fits your dry eye plan. Never self-prescribe. For full safety details, review the FDA label  

Sources & Disclaimers

• Based on TRYPTYR Prescribing Information (Alcon, 2025).  
• This blog provides general info only. Not medical advice. Consult your healthcare provider.