Lodoxamide tromethamine is a medication primarily used as an ophthalmic solution for the treatment of allergic conjunctivitis. Allergic conjunctivitis is an inflammation of the conjunctiva (the clear membrane covering the white part of the eye and lining the inner surface of the eyelids) due to allergic reactions.

Lodoxamide tromethamine works by inhibiting the release of histamine and other substances in the body that contribute to allergic reactions, thereby reducing the symptoms of allergic conjunctivitis such as itching, redness, swelling, and tearing.

Alomide (Lodoxamide tromethamine) is a mast cells stabilizer that inhibits the immediate type of hypersensitivity reactions. It is used as eye drops for the treatment of patients with keratitis and keratoconjunctivitis.

Lodoxamide tromethamine Uses:

• Ocular disorders:
  • It is used for the Treatment of ocular disorders such as vernal keratoconjunctivitis, vernal conjunctivitis, and vernal keratitis.

Lodoxamide tromethamine (Alomide) Dose in Adults:

Lodoxamide tromethamine (Alomide) Dose in the treatment of Ocular disorders:

• To treat eye problems, like allergic reactions, you can use lodoxamide tromethamine.
• You apply it directly into the affected eye(s).
• The usual dose is 1 to 2 drops in each eye, and you can do this up to 4 times a day.

Use in Children:

Refer to adults dosing.

Pregnancy Category: B

• When tested on animals, lodoxamide hasn't shown any harmful effects on reproduction when taken by mouth.
• Also, when applied directly to the eyes, the amount of lodoxamide that gets into the body is so low that it can't even be detected.

Use of Lodoxamide tromethamine during breastfeeding

• It's uncertain whether lodoxamide passes into breast milk.
• Because of this uncertainty, the manufacturer advises caution when giving lodoxamide to nursing mothers.

Dose in Kidney Disease:

• The manufacturer's instructions do not include any adjustments in dosage for people with kidney problems.
• This is likely because lodoxamide is absorbed into the body at such a low level that it's unlikely to affect kidney function.

Dose in Liver disease:

• The manufacturer's guidelines do not specify any changes in dosage for individuals with liver issues.
• This is because the low absorption of lodoxamide into the bloodstream makes it unlikely to impact liver function.

Common Side Effects of Lodoxamide tromethamine (Alomide):

• Ophthalmic:
  • Burning sensation of eyes (transient)
  • Eye discomfort (transient)
  • Stinging of eyes (transient)

Less Common Side Effects of Lodoxamide tromethamine:

• Central nervous system:
  • Foreign body sensation of eye
  • Headache
• Ophthalmic:
  • Blurred vision
  • Crystalline eye deposits
  • Eye pruritus
  • Lacrimation
  • Ocular hyperemia
  • Ocular edema
  • Xerophthalmia

Contraindications to Lodoxamide tromethamine (Alomide):

Lodoxamide should not be used in individuals who have a known hypersensitivity or allergy to lodoxamide or any of the ingredients in the formulation.

Warnings and precautions

Irritation

• Lodoxamide may cause temporary discomfort or a brief burning or stinging sensation when applied to the eyes.

Ocular effects

• Lodoxamide might temporarily blur your vision or cause other visual disturbances.
• It's important to advise patients to wait until their vision clears up before driving or operating machinery.

Monitoring Parameters:

None mentioned. Monitor the response to treatement.

How to administer Lodoxamide tromethamine (Alomide)?

For Eye Use Only:

• These eye drops are meant to be used only on the eyes and should not be injected.

Clean Hands:

• Wash your hands before using the eye drops to avoid any potential contamination.

Avoid Touching:

• Be careful not to touch the dropper tip to your eyelids or any other surfaces when putting the drops in your eyes to prevent contamination.

Remove Contact Lenses:

• Take out your contact lenses before using the eye drops.
• Wait for at least 15 minutes or longer before putting them back in after using the drops.

Mechanism of action of Lodoxamide tromethamine (Alomide):

• Lodoxamide is a type of mast cell stabilizer.
• It works by preventing a specific type of allergic reaction called the type I immediate hypersensitivity reaction.
• This reaction involves an increase in the permeability of blood vessels in the skin due to the interaction between immunoglobulin E (IgE) and antigens.
• Lodoxamide helps to inhibit this reaction, thereby reducing symptoms associated with allergic responses.

Absorption:

• When applied topically (on the surface of the body), lodoxamide is absorbed very minimally, meaning only a small amount enters the bloodstream.

Half-life elimination:

• The time it takes for half of the drug to be eliminated from the body is about 8.5 hours.

Excretion:

• Lodoxamide is primarily eliminated from the body through urine, meaning it is expelled from the body via the urine.

International Brand Names of Lodoxamide tromethamine:

• Alomide
• Alconmide
• Almide
• Lomide

Lodoxamide tromethamine Brand Names in Pakistan: