Alprazolam (Xanax) is a benzodiazepine class of medicine. It is one of the most commonly used benzodiazepine that has got a very high potential for misuse. It is also one of the most commonly misused drug that has got the most emergency department visits.
What does Xanax treat?
It is indicated for the treatment of the following conditions:
-
- Generalized anxiety disorder
- symptoms of anxiety
- panic disorders, with or without agoraphobia and,
- anxiety associated with depression.
- Adjustment disorder
Alprazolam has also been studied in the treatment of neuroleptic resistant symptoms in a subgroup of patients with chronic schizophrenia [Ref].
Alprazolam for sleep (Insomnia):
Xanax (alprazolam) is used primarily to treat symptoms of anxiety, however, because of its hypnotic effects, it is commonly used for sleep-related disorders. Hypnotic drugs are primarily used for insomnia. Other drugs that may be used for insomnia include zolpidem, barbiturates, zopiclone, and eszopiclone. Certain antihistamines like chlorpheniramine can also cause excessive sleep. Atypical antidepressants like trazodone ((Deprel) also cause excessive sleepiness.
Is Xanax good for depression?
Alprazolam (Xanax) is primarily used for the treatment of anxiety and panic attacks. In mild cases of depression, Xanax may be used as a temporary measurement. Since chronic use of Alprazolam can result in dependence, addiction, and tolerance, it is usually given for a short period of time. When used for depression, its use should not exceed two weeks. This is the time when most of the SSRIs (like escitalopram and Effexor) become effective. It is used in depression associated with anxiety and in patients with depressive psychosis. It is considered unintelligent to combine CNS stimulants like modafinil and Xanax. In a review of 25 studies, alprazolam was more effective than placebo and as effective as amitriptyline, clomipramine, desipramine, dothiepin, doxepin, and imipramine, for the treatment of “neurotic” or moderate depression [Ref]. However, in severe depression, it was inferior to these medicines. When given concomitant with alcohol, the toxicity of Xanax is increased as alcohol inhibits the enzyme CYP3A4 [Ref]. [bg_collapse view="button-blue" color="#f7f2f2" icon="arrow" expand_text="Dose in Adults" collapse_text="Dose in Adults" ]
Alprazolam (Xanax) dose in Anxiety (Generalized anxiety disorder with or without agoraphobia):
-
Immediate-release Xanax tablets:
- 0.25-0.5 mg orally thrice daily initially;
- The dose should be titrated upwards every third or fourth day by no more than 1 mg/day
- The usual maximum dose is 4 mg/day.
- Patients requiring doses greater than 4 mg/day should be increased cautiously.
Alprazolam (Xanax) dose in Panic disorder:
-
Immediate-release Xanax tablets:
- 0.5 mg orally thrice daily
- The dose may be increased every third or fourth day in increments less than 1 mg/day.
- The mean effective dosage is 5-6 mg daily. The patients may occasionally require up to 10 mg of alprazolam per day.
-
Extended-release Xanax tablets:
- 0.5 mg to 1 mg orally initially once a day.
- The extended-release tablets should be preferably taken in the morning
- Lean and thin patients should be given the lowest possible dose initially and increased every third or fourth day by nor more than 1 mg.
- Up to 10 mg/day has been required in occasional patients.
Xanax tablets dose in Pre-operative anxiety:
- 0.5 mg tablets 60-90 minutes before the procedure.
Xanax dose in elderly patients:
-
Immediate-release tablets:
- 0.25 mg twice or thrice daily initially.
-
Extended-release tablets:
- 0.5 mg once a day.
Start with a lower initial dose and increase the dose gradually, if required. The maximum adult dosage is 4 mg/day. The elderly may be more sensitive to the effects of benzodiazepines. If discontinuation becomes necessary, the manufacturer suggests that the daily dose be decreased by no more than 0.5 mg every 3 days.
Alprazolam dose for the treatment of anxiety and mood-symptoms associated with premenstrual syndrome (PMS) or premenstrual dysphoric disorder (PMDD) that is unresponsive to non-pharmacologic therapy.
Immediate-release oral tablets or solution:
- Adult females
- 0.25 mg orally three times daily administered during the luteal phase through the second day of menses.
- A maximum dose of up to 4 mg per day is recommended.
- The dose should be tapered by 25% per day through menses.
Maximum dose of Xanax:
-
Adults:
- 10 mg/day PO.
-
Geriatric:
- 10 mg/day PO.
-
Adolescents:
- Safety and efficacy have not been established; 0.06 mg/kg/day orally
-
Children
-
7 years and older:
- Safety and efficacy have not been established
- 0.06 mg/kg/day orally
-
Less than 7 years:
- Safety and efficacy have not been established.
-
Tapering off Xanax:
Abrupt discontinuation should be avoided. The daily dose may be decreased by 0.5 mg every third day. Patients on long term use alprazolam should be tapered the drug very slowly. The previous dose should be resumed if withdrawal symptoms start while reducing the dose. [/bg_collapse]
Alprazolam (Xanax) dose in Children for anxiety:
- Oral Immediate-release formulation:
- 0.005 mg/kg/dose or 0.125 mg/dose thrice daily initially;
- Increase the dose in increments of 0.125-0.25 mg to the maximum dose 0.02 mg/kg/dose.
Note: Treatment of more than 4 months should be re-evaluated to determine the patient's continued need for the drug.
Alprazolam dose in renal disease:
Dosage adjustment in renal disease has not been provided in the manufacturer's labeling
Alprazolam dose in advanced liver disease:
Immediate release:
- 0.25 mg twice or thrice daily.
Extended-release tablets:
- 0.5 mg once daily. Titrate the dose gradually if needed and tolerated.
- It should be administered cautiously to patients with severe hepatic disease because the elimination half-life of the drug can be prolonged, possibly resulting in toxicity.
How and when to take Xanax (Alprazolam)?
- The Immediate-release preparations can be taken orally or sublingually at bedtime.
- The Extended-release tablet should be taken once daily in the morning.
- The extended-release tablet should not be broken, crushed or chewed.
Xanax Pregnancy Risk Factor D
- Benzodiazepines can cross the placental boundary and cause harm to the fetus.
- It has been associated with premature births, low birthweights, neonatal withdrawal syndrome and floppy infant syndromes in the third trimester.
- Breastfeeding is not advised as alprazolam can enter breast milk.
- Alprazolam may cause sleepiness and lethargic in babies if it is given to their mothers.
Severe Side effects of Alprazolam (Xanax):
Rapid:
- Angioedema
Delayed:
- Seizures
- Stevens-Johnson syndrome
- Hepatic failure
- Teratogenesis
Moderately severe side effects of Xanax:
Rapid:
- Sinus Tachycardia
- Hypotension
Early:
- Withdrawal
- Impaired cognition
- Confusion
- Hot flashes
- Euphoria
- Mania
- Urinary Incontinence
- Dysuria
- Photophobia
- Dyspnea
- Hallucinations
- Blurred vision
- Palpitation
- Chest pain
- Hostility
Delayed:
- memory impairment
- Constipation
- Dysarthria
- Depression
- Ataxia
- Edema
- Akathisia
- Dyskinesia
- Amnesia
- Dysphonia
- Hypotonia
- Tolerance
- Psychological dependence
- Physiological dependence
- Peripheral edema
- Jaundice
- Hyperbilirubinemia
- Elevated hepatic enzymes
- Hyperprolactinemia
- Hepatitis
- Galactorrhea
Mild side effects of Xanax:
Rapid:
- Pruritis
- Urticaria
Early:
- Drowsiness
- Fatigue
- Dizziness
- Nausea
- Xerostomia
- Hypersalivation
- Syncope
- Lethargy
- Myalgia
- Psychomotor impairment
- Rhinorrhea
- Rash
- Mydriasis
- Fever
- Agitation
- Nightmares
- Tremors
- Malaise
- Vertigo
- Insomnia
- Weakness
- Headache
- Hyperventilation
- Diaphoresis
- Nasal congestion
- Rhinitis
- Diarrhea
- Dyspepsia
- Abdominal pain
- Vomiting
- Diplopia
Delayed:
- Appetite stimulation
- Weight gain
- Weight loss
- Anxiety
- Libido decrease
- Menstrual irregularity
- Libido increase
- Infection
- Dysmenorrhea
- Paresthesias
- Arthralgia
- Influenza
- Anorexia
- Asthenia
- Tinnitus
- Epistaxis
- Irritability
- Back pain
- Muscle cramps
- Gynecomastia
Contraindications to alprazolam (Xanax) include:
- Alprazolam allergy (cross-sensitivity may exist with other benzodiazepines)
- Narrow-angle Glaucoma
- Patients with Myasthenia Gravis, Guillain Barre Syndrome, Chronic Obstructive Airway Disease, and all others at risk for developing respiratory failure.
- Patients receiving itraconazole or ketoconazole.
- Patients who have had seizures in the past should not be prescribed benzodiazepines. Withdrawal of the drug could cause seizures. There have been reports of patients falling into epilepticus after benzodiazepines were stopped. It is the first 24 to 72 hours after stopping taking drugs that you are most at risk for seizures.
- Alprazolam can cause psychological and physical dependence, especially if taken in high doses for longer than 12 weeks.
- Alprazolam's short duration has been linked to reports of anxiety that worsens daily.
- Alprazolam should not be prescribed to patients with hypomania, mania, bipolar disorder, mania and suicidal thoughts.
- Patients in shock and patients taking ethanol may experience CNS depression and low blood pressure. Alprazolam should not be prescribed to heavy machinery operators, especially drivers.
- Patients with Parkinson's should avoid it as it can worsen symptoms, impair cognition, and cause psychosis.
- Patients with porphyria should avoid it.
Alprazolam (Xanax), Boxed Warning
- Chronic obstructive pulmonary disease (COAD)
- Coadministration with CNS depressants
- Other chronic pulmonary diseases
- Respiratory depression is a condition that can lead to and
- Sleep apnea
- Alprazolam should not be used in these conditions because it can cause respiratory depression, low blood pressure, or even death. Patients at high risk for ventilatory failures, such as patients with Guillain Barre Syndrome, Opioid overdose and myasthenia should not use it.
Warnings and precautions
-
Anterograde amnesia:
- Memory impairment may be caused by benzodiazepines
-
Depression in the CNS:
- Drivers and operators of heavy machinery should avoid it as it can cause CNS depression.
-
Paradoxical reactions:
- Teens and young adults can become aggressive and hyperactive, particularly in the case of patients.
-
Depression:
- Patients with hypomania and suicidal tendencies should not take benzodiazepines.
-
Use of drugs:
- It can cause psychological and physical dependence if it is used for a prolonged period.
-
Hepatic impairment
- Patients suffering from liver disease should be cautious when using the drug.
-
Renal impairment
- Patients with kidney disease may develop urate-nephropathy.
-
Respiratory disease:
- It can cause depression in the respiratory system.
Alprazolam (Xanax) MOA (Mechanism of action):
- Alprazolam (Xanax), binds to receptors in the central nervous system at the postsynaptic GABA nerven.
- This results in membrane permeability for chloride ions, which causes hyperpolarization and stabilization.
The beginning of action: Instant release and extended-release formulations available in 1 hour
Time: Immediate-release - 5.1 +-1.7 hours; Extended - Release - 11.3 +-4.2 hours
AbsorptionExtended-release: Longer-lasting formulations are slower than immediate-release formulations. This means that the concentration is maintained for 5-11 hours after each dose
Protein binding: 80% of the protein is bound to albumin, primarily proteins
MetabolismCYP3A4 is the pathway that it is metabolized in your liver
BioavailabilityIt is bioavailable at about 90%.
Half-life elimination:
Adults: 11.2 Hours (Immediate Release Range: 6.3-26.9 Hours; Extended-release Range: 10.7-15.8 Hours); Orally-disintegrating Tablet Range: 7.9-19.2 Stunden Seniors: 16.3 hours (range 9-26.9hrs) Alcoholic liver disease: 19.7 hours (range 5.8-65.3 hours). Obesity: 21.8 hours (range 9.9-40.4hrs) Race: Asians have a higher rate of incarceration than Caucasians.
Time to reach peak serum concentrations: Released immediately: Within 1-2 hours Extended-release: approximately 9 hours When administered at night, peak serum concentrations are reduced by an hour (as opposed to morning administration), and decrease by 33% when combined with high-fat meals (increased 33% if administered more than one hour after high-fat meals). Orally disintegrating tablet takes 1.5-2 hours When administered with water, the time to peak serum concentration takes approximately 15 minutes. It is reduced by two hours when taken with high-fat meals.
Excretion: Urine (as an unchanged drug or metabolite)
Alprazolam brand names in Pakistan:
ALORAM (GLOBAL PHARMACEUTICALS)
Tablets : 2 mg :
30 tablets pack : Rs. 357.00
Tablets : 0.25 mg :
30 tablets pack : Rs. 77.00
Tablets : 0.5 mg :
30 tablets pack : Rs. 128.00
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
ALP (HILTON PHARMA (PVT) LIMITED)
Tablets : 0.5 mg :
30 tablets pack : Rs. 124.05
Tablets : 0.25 mg :
30 tablets pack : Rs. 132.45
Tablets : 1 mg :
30 tablets pack : Rs. 233.20
ALPAMED (MEDIFINE LABORATORIES)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128.05
Tablets : 0.25 mg :
30 tablets pack : Rs. 77.00
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
ALPAX (EFROZE CHEMICAL INDUSTRIES (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 160
Tablets : 0.25 mg :
30 tablets pack : Rs. 115
ALPRAM (AKHAI PHARMACEUTICALS)
Tablets : 0.5 mg :
30 tablets pack : Rs. 137.37
ALPRANAX (STAR LABORATORIES (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 90
Tablets : 0.25 mg :
30 tablets pack : Rs. 60
ALPRAZOTA (ORTA LABS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
ANPRA (CIRIN PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 105
Tablets : 0.25 mg :
30 tablets pack : Rs. 70
Tablets : 1 mg :
30 tablets pack : Rs. 175.00
ANRID (EVRON (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 160
100 tablets pack : Rs. 506
ANXIORID (MEDICRAFT PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 100
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
ANXNIL (PHARMIX LABORATORIES (PRIVATE) LIMITED)
Tablets : 0.5 mg :
30 tablets pack : Rs. 112.50
ANXOTEN (BLOOM PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
AXAL (AMSON VACCINES & PHARMA (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 155
Tablets : 0.25 mg :
30 tablets pack : Rs. 110
Tablets : 1 mg :
30 tablets pack : Rs. 265.00
AZOLAM (MERCK PRIVATE LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 102
Tablets : 0.25 mg :
30 tablets pack : Rs. 134
Tablets : 1 mg :
30 tablets pack : Rs. 268.00
AZOLEX (PHARMACARE LABORATORIES (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 90
Tablets : 1 mg :
30 tablets pack : Rs. 160
BIZOLAM (BIO LABS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
ENZO (MACTER INTERNATIONAL (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 90
Tablets : 0.25 mg :
30 tablets pack : Rs. 60
Tablets : 1 mg :
30 tablets pack : Rs. 150
HILAXIN (HIMONT PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 156
Tablets : 0.25 mg :
30 tablets pack : Rs. 98
LAMPRO (SAFFRON PHARMACEUTICAL COMPANY)
Tablets : 0.5 mg :
30 tablets pack : Rs. 129
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
LAMZO (GENIX PHARMA (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
LAPRANX (BRYON PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 102
Tablets : 0.25 mg :
30 tablets pack : Rs. 71
Tablets : 1 mg :
30 tablets pack : Rs. 200
LEAZAM (LEADS PHARMA (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
LYDIA (WILSHIRE LABORATORIES (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
MAZOLAM (MUNAWAR PHARMA (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 90
Tablets : 0.25 mg :
30 tablets pack : Rs. 60
Tablets : 1 mg :
30 tablets pack : Rs. 170.00
MULIS (PLIVA PAKISTAN (PVT) LIMITED)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
NERAM (GENIX PHARMA (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128.00
NERVIN (WERRICK PHARMACEUTICALS)
Tablets : 0.5 mg :
30 tablets pack : Rs. 95
Tablets : 0.25 mg :
30 tablets pack : Rs. 76
Tablets : 1 mg :
30 tablets pack : Rs. 176.00
NEUXAM (STANDPHARM PAKISTAN (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 149
Tablets : 0.25 mg :
30 tablets pack : Rs. 89
Tablets : 1 mg :
30 tablets pack : Rs. 264.00
NIZAM (UNIVERSAL PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
NOXALAM (PLATINUM PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
ONAX (SAFE PHARMACEUTICAL (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 100
Tablets : 0.25 mg :
30 tablets pack : Rs. 70
Tablets : 1 mg :
30 tablets pack : Rs. 214.00
PINIX (ADAMJEE PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
PRANAX (ARIES PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
PRAZODAN (DANAS PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
PRAZOLAM (NOVA MED PHARMACEUTICALS)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
PROLAM (GLITZ PHARMA)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
PROZAM (RAKAPOSHI PHARMACEUTICAL (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 98
RAZLAM (LOWITT PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
ROSAM (HELICON PHARMACEUTEK PAKISTAN (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 98
SHENLAX (HIGH - Q INTERNATIONAL)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
SYMS (XENON PHARMACEUTICALS (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
VALOZAM (VALOR PHARMACEUTICALS)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
XANAX (PFIZER LABORATORIES LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 219
Tablets : 0.25 mg :
30 tablets pack : Rs. 157
Tablets : 1 mg :
30 tablets pack : Rs. 436
XOLAM SR (GLOBAL PHARMACEUTICALS)
Tablets : 0.5 mg :
30 tablets pack : Rs. 418
Tablets : 0.25 mg :
30 tablets pack : Rs. 210
Tablets : 1 mg :
30 tablets pack : Rs. 697
XYLEPAM (BROOKES PHARMACEUTICAL LABORATORIES (PAK) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 100
Z-NEST (INDUS PHARMA (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
ZENITH (FEROZSONS LABORATOIES LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 88
Tablets : 0.25 mg :
30 tablets pack : Rs. 47
Tablets : 1 mg :
30 tablets pack : Rs. 170
ZOLAM (SAYDON PHARMACEUTICAL INDUSTRIES (PVT) LTD)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
ZOLGRAY (GRAY`S PHARMACEUTICALS)
Tablets : 0.5 mg :
30 tablets pack : Rs. 128
Tablets : 0.25 mg :
30 tablets pack : Rs. 77
Tablets : 1 mg :
30 tablets pack : Rs. 214
Tablets : 2 mg :
30 tablets pack : Rs. 357
M-ZOLAM (MEDIATE PHARMACEUTICALS (PVT) LTD)
Tablets : 0.25 mg
30 tablets pack : Rs. 70.59 [/bg_collapse]
Alprazolam Brand Names (International):
- Aceprax
- Actazolam
- Alcelam
- Alnax
- Alpaz
- Alplax
- Alpralid
- Alpraline
- Alpranax
- Alprax
- Alpraz
- Alprocontin
- Alprox
- Altrox
- Alviz
- Alzam
- Alzax
- Alzolam
- Anpress
- Ansiolit
- Apo-Alpraz
- Apraz
- Aprazo
- Asolan
- Axal
- Azor
- Cassadan
- Constan
- Dixin
- Farmapram
- Feprax
- Frontal
- Frontin
- Helex
- Irizz.
- Kalma
- Kinax
- Marzolam
- Neupax
- Pacyl
- Pharnax
- Prazol
- Prazovex
- Prinox
- Solanax
- Soxietas
- Tafil
- Tafil D
- Tazun
- Trankimazin Retard
- Tranquinal
- Tricalma
- Valeans
- Xanacine
- Xanagis
- Xanax
- Xanax SR
- Xanax XR
- Xanor
- Xanor XR
- Zacetin
- Zanapam
- Zolam
- Zolarem
- Zolastin
- Zoldac
- Zopax
- Zotran
- Zypraz
- Zyren
 Injection.webp)