Framycetin (Soframycin) is an aminoglycoside antibiotic that is available as an ophthalmic formulation. It is intended for the treatment of eye infections caused by susceptible organisms.
Framycetin (Soframycin) Uses:
-
Ophthalmic infection/ conditions:
- It is indicated for the treatment of eye infections caused by susceptible bacteria such as S. aureus, Proteus spp., P. aeruginosa, and coliforms.
- It is also indicated for the treatment of corneal ulcers, abrasions, and burns.
- It may also be used as prophylaxis following removal of foreign bodies.
Framycetin (Soframycin) Dose in Adults
Framycetin (Soframycin) Dose in the treatment of Ophthalmic infections/conditions:
- Ophthalmic:
- Instill 1 to 2 drops in the affected eye 3 to 4 times a day.
- For rapid relief in patients with acute conditions, 1 - 2 drops may be instilled every 1 - 2 hours for 2 - 3 days.
Use in Children:
Not indicated.
Pregnancy Risk Category: D
- The use of aminoglycosides in pregnancy can have serious adverse effects on the fetus.
- Use of aminoglycosides during pregnancy has been linked to congenital hearing loss and other adverse outcomes related to the kidneys.
Use during breastfeeding:
- Aminoglycosides can be poorly absorbed through the gastrointestinal tract.
- It can alter the bacterial flora, so breastfeeding women should be cautious.
Dose in Kidney Disease:
The manufacturer's labelling does not mention dosage modifications.
Dose in Liver disease:
The manufacturer's labelling does not mention dosage modifications.
Side effects of Framycetin (Soframycin):
-
Cardiovascular (With High Doses):
- Cardiac Arrhythmia
- Increased Blood Pressure
- Palpitations
- Tachycardia
-
Central Nervous System (With High Doses):
- Central Nervous System Depression
- Dizziness
- Drowsiness
- Headache
- Insomnia
- Nervousness
-
Gastrointestinal:
- Dry Mucous Membranes
-
Miscellaneous:
- Burn
-
Ophthalmic:
- Blurred Vision
-
Respiratory:
- Rhinorrhea
- Sneezing
- Stinging Sensation Of The Nose
Contraindications to Framycetin (Soframycin):
- Allergy to the drug, any other aminoglycoside antibiotics or any component of this formulation
- The possibility of cross-sensitivity may exist with other Streptomyces-derived antibiotics such as neomycin, paromomycin, and kanamycin.
Warnings and precautions
-
Superinfection
- Long-term use of the drug could lead to bacterial superinfections or fungal infections.
Framycetin: Drug Interaction
|
Risk Factor C (Monitor therapy) |
|
|
Lactobacillus and Estriol |
The therapeutic effects of Lactobacillus and Estriol may be reduced by antibiotics. |
Monitoring parameters:
- Monitor for improvement in the symptoms/ infection.
How to administer Framycetin (Soframycin)?
Ophthalmic:
- Before administering the drug, wash hands.
- It is intended for topical ophthalmic use only.
- Do not touch the applicator's tip to eyes or other surfaces.
Mechanism of action of Framycetin (Soframycin):
- It is an antibiotic with broad spectrum of action belonging to the class of aminoglycosides.
- It is bactericidal, and inhibits protein synthesis in susceptible bacteria through binding ribosomal reunits.
- It is active against both aerobic gram negative and aerobic gram positive bacteria.
International Brand Names of Framycetin:
- Soframycin
- Daryant-Tulle
- Fracitin
- Frade
- Framycin
- Isofra
- Izofra
- Leukase N
- MB-Tulle
- Sofra-tull
- Sofra-Tulle
- Soframycin
- Soframycin Ear/Eye Drops
- Soframycine
Framycetin Brand Names in Pakistan:
No Brands Available in Pakistan.
 Injection.webp)