Framycetin (Soframycin) is an aminoglycoside antibiotic that is available as an ophthalmic formulation. It is intended for the treatment of eye infections caused by susceptible organisms.

Framycetin (Soframycin)  Uses:

• Ophthalmic infection/ conditions:

  • It is indicated for the treatment of eye infections caused by susceptible bacteria such as S. aureus, Proteus spp., P. aeruginosa, and coliforms.
  • It is also indicated for the treatment of corneal ulcers, abrasions, and burns.
  • It may also be used as prophylaxis following removal of foreign bodies.

Framycetin (Soframycin) Dose in Adults

Framycetin (Soframycin) Dose in the treatment of Ophthalmic infections/conditions:

• Ophthalmic:
  • Instill 1 to 2 drops in the affected eye 3 to 4 times a day.
  • For rapid relief in patients with acute conditions, 1 - 2 drops may be instilled every 1 - 2 hours for 2 - 3 days.

Use in Children:

Not indicated.

Pregnancy Risk Category: D

• The use of aminoglycosides in pregnancy can have serious adverse effects on the fetus. 
• Use of aminoglycosides during pregnancy has been linked to congenital hearing loss and other adverse outcomes related to the kidneys.

Use during breastfeeding:

• Aminoglycosides can be poorly absorbed through the gastrointestinal tract. 
• It can alter the bacterial flora, so breastfeeding women should be cautious.

Dose in Kidney Disease:

The manufacturer's labelling does not mention dosage modifications.

Dose in Liver disease:

The manufacturer's labelling does not mention dosage modifications.

Side effects of Framycetin (Soframycin):

• Cardiovascular (With High Doses):

  • Cardiac Arrhythmia
  • Increased Blood Pressure
  • Palpitations
  • Tachycardia

• Central Nervous System (With High Doses):

  • Central Nervous System Depression
  • Dizziness
  • Drowsiness
  • Headache
  • Insomnia
  • Nervousness

• Gastrointestinal:

  • Dry Mucous Membranes

• Miscellaneous:

  • Burn

• Ophthalmic:

  • Blurred Vision

• Respiratory:

  • Rhinorrhea
  • Sneezing
  • Stinging Sensation Of The Nose

Contraindications to Framycetin (Soframycin):

• Allergy to the drug, any other aminoglycoside antibiotics or any component of this formulation
• The possibility of cross-sensitivity may exist with other Streptomyces-derived antibiotics such as neomycin, paromomycin, and kanamycin.

Warnings and precautions

• Superinfection

  • Long-term use of the drug could lead to bacterial superinfections or fungal infections.

Framycetin: Drug Interaction

Monitoring parameters:

• Monitor for improvement in the symptoms/ infection.

How to administer Framycetin (Soframycin)?

Ophthalmic:

• Before administering the drug, wash hands.
• It is intended for topical ophthalmic use only.
• Do not touch the applicator's tip to eyes or other surfaces.

Mechanism of action of Framycetin (Soframycin):

• It is an antibiotic with broad spectrum of action belonging to the class of aminoglycosides. 
• It is bactericidal, and inhibits protein synthesis in susceptible bacteria through binding ribosomal reunits.
• It is active against both aerobic gram negative and aerobic gram positive bacteria.

International Brand Names of Framycetin:

• Soframycin
• Daryant-Tulle
• Fracitin
• Frade
• Framycin
• Isofra
• Izofra
• Leukase N
• MB-Tulle
• Sofra-tull
• Sofra-Tulle
• Soframycin
• Soframycin Ear/Eye Drops
• Soframycine

Framycetin Brand Names in Pakistan:

No Brands Available in Pakistan.