Fusidic acid and hydrocortisone are combined to create Fucidin H Cream. An effective bacteriostatic antibiotic for treating skin infections is fusidic acid. When used topically, the low-potency corticosteroid hydrocortisone lessens the inflammation brought on by some illnesses and skin diseases.
Fucidin H (Fusidic acid and Hydrocortisone) Uses:
Note: Not approved in the US.
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Atopic dermatitis:
- For mild to moderate atopic dermatitis, according to susceptibility
Fucidin H (Fusidic acid and Hydrocortisone) Dose in Adults
Fucidin H (Fusidic acid and Hydrocortisone) Dose in the treatment of Atopic dermatitis:
- Topical: Apply 3 times daily for ≤14 days
Dose in Children:
Refer to adults' dosing.
Pregnancy and Breastfeeding Implications:
- Contact individual agentsFusidic acid and hydrocortisone.
- It has minimal systemic absorption and can be applied topically.
- This means that it will not have any effect on the development and growth of the foetus. It can also be safely used while breastfeeding.
Dose in renal disease:
No adjustment in the dose has been recommended.
Dose in liver disease:
No adjustment in the dose has been recommended.
Side effects of Fucidin H (Fusidic acid and Hydrocortisone):
-
Dermatologic:
- Dermatitis
- Acne Rosacea
- Atrophic Striae
- Burning Sensation Of Skin
- Dyschromia
- Hypertrichosis
- Pruritus
- Secondary Skin Infection
- Skin Atrophy
- Subcutaneous Atrophy
- Telangiectasia
- Xeroderma
-
Hypersensitivity:
- Hypersensitivity Reaction
-
Local:
- Local Irritation
Contraindications to Fucidin H (Fusidic acid and Hydrocortisone):
- Intolerance to hydrocortisone acetate, fusidic, or any other ingredient in the formulation
- Mould infections
- Skin with tuberculosis
- Skin syphilis infections
- Chickenpox outbreaks and viral skin conditions follow immunizations
Warnings and precautions
-
Suppression of the adrenals:
- Systemic absorption is sufficient to cause hypercortisolism or to block the hypothalamic-pituitary-adrenal (HPA) axis, which may even result in an adrenal crisis, especially in youngsters or patients on long-term, high-dose steroids.
-
Sensitization:
- Topical application can cause local irritation or erythema. If this happens, discontinue use.
-
Systemic effects
- Hyperglycemia or Cushing syndrome may result from systemic absorption.
- When applied to a large area or covered with a dressing, absorption is increased
Fusidic acid and hydrocortisone: Drug Interaction
|
Risk Factor C (Monitor therapy) |
|
|
Corticorelin |
The therapeutic benefit of corticorelin may be reduced by corticosteroids. In particular, recent or ongoing corticosteroid medication may reduce the plasma ACTH response to corticorelin. |
|
Deferasirox |
Corticosteroids may intensify Deferasirox's negative/toxic effects. Particularly, there may be a higher risk of GI bleeding or ulcers. |
|
Ritodrine |
Corticosteroids may intensify Ritodrine's harmful or hazardous effects. |
|
Risk Factor D (Consider therapy modification) |
|
|
Hyaluronidase |
The therapeutic benefit of hyaluronidase may be reduced by corticosteroids. Treatment: Standard doses of hyaluronidase may not produce the desired clinical response in patients using corticosteroids (especially at higher doses). Hyaluronidase may be needed at higher doses. |
|
Risk Factor X (Avoid combination) |
|
|
Aldesleukin |
The anti-cancer effects of corticosteroids may be diminished by aldesleukin. |
Monitoring parameters:
None mentioned. Monitor the response to treatment
How to administer Fucidin H (Fusidic acid and Hydrocortisone)?
Topical: For external use only. Follow directions in the label for site, duration, and frequency of application.
Mechanism of action of Fucidin H (Fusidic acid and Hydrocortisone):
See individual agents: Fusidic acid and hydrocortisone
Absorption:
-
- Fusidic acid: 2%, hydrocortisone Acetate: 1% to 55%. Skin that is damaged will increase absorption.
International Brand Names of Fusidic acid and Hydrocortisone:
- Fucidin H
- Curoderm-H
- Disuf-H
- Foban Hydro
- Fucidin H
- Fucidin Hydrocortison
- Fucidin Hydrocortisone
- Fucidin-H
- FucidinHydrocortison
- Fucidine H
- Fucil-hc
- Fusac-H
- Fusicort
- Fusidate H
- Fusiderm HC
- Fusitrim
- Fuson-H
Fusidic acid and hydrocortisone Brand Names in Pakistan:
Fusidic Acid and Hydrocortisone Cream 2 %w/w in Pakistan |
|
| Curoderm-H | Epla Laboratories (Pvt) Ltd. |
| Dermafuse-H | Everest Pharmaceuticals |
| Fosedic-H | Pearl Pharmaceuticals |
| Fsid-H | Derma Techno Pakistan |
| Fucicort | Zam Zam Corporation |
| Fucidin-H | Zam Zam Corporation |
| Fucirog-H | Rogen Pharmaceuticals |
| Fudic H | Shaigan Pharmaceuticals (Pvt) Ltd |
| Fusac-H | Sante (Pvt) Limited |
| Fusac-H | Sante (Pvt) Limited |
| Fusiaim H | Aims Traders |
| Fusiderm-H | Seatle Pharma Pakistan (Pvt) Ltd. |
| Fusil-Hc | Tabros Pharma |
| Fusimed-H | Medera Pharmaceuticals (Pvt) Ltd. |
| Fusinex | Reliance Pharma |
| Genidic -H | Biogen Pharma |
| Hy-Cib | Linear Pharma |
| Noviskin-H | Novins International |
| Pathoderm-H | Davis Pharmaceutical Laboratories |
| Pathoderm-H | Davis Pharmaceutical Laboratories |
| Phusilan-H | Sulk Pharma |
| Secodic-H | Shazals Pharmaceuticals |
| Sidicort | Epoch Pharmaceutical |
| Sidik-H | Dermagen Pharma Pakistan (Pvt) Limited |
| Tadic | Linear Pharma |
| Udic-H | Valor Pharmaceuticals |
| Usibet | Pacific Pharmaceuticals Ltd. |
| Usidin-H | Pacific Pharmaceuticals Ltd. |
| Zudicort | Nabiqasim Industries (Pvt) Ltd. |
| Zudicort | Nabiqasim Industries (Pvt) Ltd. |
 Injection.webp)