Isoxsuprine (Vasodilan) is a vasodilator drug that acts via beta-2 adrenergic receptors in the uterine smooth muscles and directly acts on the vascular smooth muscles causing vasodilation.
Isoxsuprine (Vasodilan) Uses:
- It is indicated for the treatment of peripheral vascular diseases such as thrombangiits obliterans (Buerger's disease), Raynauds Disease, and arteriosclerosis obliterans
- It is also used to treat the symptoms of cerebrovascular insufficiency.
Isoxsuprine (Vasodilan) Dose in Adults:
Isoxsuprine (Vasodilan) Dose in the treatment of Peripheral vascular disease or symptoms of cerebrovascular insufficiency:
- Oral: 10 to 20 mg three or four times a day.
Use in children:
Not indicated.
Isoxsuprine (Vasodilan) Pregnancy Risk Category: C
- The drug can pass the placental barrier.
- Mothers who are currently receiving treatment for their infants may experience adverse events such as hypocalcemia, hypoglycemia and hypotension. Infants may require urgent treatment.
- Beta-stimulants may cause pulmonary edema in the mother. It has been associated with tachycardia in both the fetal as well as the maternal sexes.
- Preterm labor has not been treated with this drug. Its effects on the uterine smooth muscle have been studied.
Isoxsuprine use during breastfeeding:
- It is unknown if the drug will be excreted into breastmilk.
Dose in Kidney Disease:
There are no dosage adjustments provided in the manufacturer’s labeling.
Dose in Liver disease:
There are no dosage adjustments provided in the manufacturer’s labeling.
Side effects of Isoxsuprine (Vasodilan):
-
Cardiovascular:
- Chest pain
- Hypotension
- Tachycardia
-
Central nervous system:
- Dizziness
-
Dermatologic:
- Skin rash
-
Gastrointestinal:
- Abdominal distress
- Nausea
- Vomiting
Contraindications to Isoxsuprine (Vasodilan):
- Arterial bleeding;
- Postpartum, it is best to not use it immediately
Warnings and precautions
-
Rash:
- It is possible to get a severe, drug-induced rash from its use.
- It is imperative to stop all treatment immediately.
Monitoring parameters:
None mentioned.
How to administer Isoxsuprine (Vasodilan)?
It may be administered with or without meals.
Mechanism of action of Isoxsuprine (Vasodilan):
- It increases blood flow in the muscles, but has minimal effect on the blood supply to the skin.
- The drug directly affects the smooth muscles of vessels. It doesn't cause vasodilation through activating beta receptors.
- However, the drug's effects upon beta-adrenergic receptors stimulate the uterine muscles.
Absorption:
- It is rapidly and completely absorbed.
Time to peak, serum:
- One hour;
- The serum concentrations are maintained for at least three hours.
Excretion:
- Urine.
International Brands of Isoxsuprine:
- Vasodilator
- Dilator
- Dilum
- Dubodyran
- Duvacare
- Duvadilan
- Duvadilan Retard
- Duvagen
- Evaprine
- Hystolan
- Inibina
- Isodilan
- Isodiran
- Isoprin
- Isoxilan
- Isoxine
- Proterine
- Suprinex
- Synzedrin
- Tonotan
- Uteprine
- Uterine
- Vasoplex
- Vasosuprina
- Xuprin
Isoxsuprine Brand Names in Pakistan:
No Brands Available in Pakistan.
 Injection.webp)