Isoxsuprine (Vasodilan) is a vasodilator drug that acts via beta-2 adrenergic receptors in the uterine smooth muscles and directly acts on the vascular smooth muscles causing vasodilation.

Isoxsuprine (Vasodilan) Uses:

• It is indicated for the treatment of peripheral vascular diseases such as thrombangiits obliterans (Buerger's disease), Raynauds Disease, and arteriosclerosis obliterans
• It is also used to treat the symptoms of cerebrovascular insufficiency.

Isoxsuprine (Vasodilan) Dose in Adults:

Isoxsuprine (Vasodilan) Dose in the treatment of Peripheral vascular disease or symptoms of cerebrovascular insufficiency:

• Oral: 10 to 20 mg three or four times a day.

Use in children:

Not indicated.

Isoxsuprine (Vasodilan) Pregnancy Risk Category: C

• The drug can pass the placental barrier.
• Mothers who are currently receiving treatment for their infants may experience adverse events such as hypocalcemia, hypoglycemia and hypotension. Infants may require urgent treatment.
• Beta-stimulants may cause pulmonary edema in the mother. It has been associated with tachycardia in both the fetal as well as the maternal sexes.
• Preterm labor has not been treated with this drug. Its effects on the uterine smooth muscle have been studied.

Isoxsuprine use during breastfeeding:

• It is unknown if the drug will be excreted into breastmilk.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Side effects of Isoxsuprine (Vasodilan):

• Cardiovascular:

  • Chest pain
  • Hypotension
  • Tachycardia

• Central nervous system:

  • Dizziness

• Dermatologic:

  • Skin rash

• Gastrointestinal:

  • Abdominal distress
  • Nausea
  • Vomiting

Contraindications to Isoxsuprine (Vasodilan):

• Arterial bleeding;
• Postpartum, it is best to not use it immediately

Warnings and precautions

• Rash:

  • It is possible to get a severe, drug-induced rash from its use.
  • It is imperative to stop all treatment immediately.

Monitoring parameters:

None mentioned.

How to administer Isoxsuprine (Vasodilan)?

It may be administered with or without meals.

Mechanism of action of Isoxsuprine (Vasodilan):

• It increases blood flow in the muscles, but has minimal effect on the blood supply to the skin.
• The drug directly affects the smooth muscles of vessels. It doesn't cause vasodilation through activating beta receptors.
• However, the drug's effects upon beta-adrenergic receptors stimulate the uterine muscles.

Absorption:

• It is rapidly and completely absorbed.

Time to peak, serum:

• One hour;
• The serum concentrations are maintained for at least three hours.

Excretion:

• Urine.

International Brands of Isoxsuprine:

• Vasodilator
• Dilator
• Dilum
• Dubodyran
• Duvacare
• Duvadilan
• Duvadilan Retard
• Duvagen
• Evaprine
• Hystolan
• Inibina
• Isodilan
• Isodiran
• Isoprin
• Isoxilan
• Isoxine
• Proterine
• Suprinex
• Synzedrin
• Tonotan
• Uteprine
• Uterine
• Vasoplex
• Vasosuprina
• Xuprin

Isoxsuprine Brand Names in Pakistan:

No Brands Available in Pakistan.