Luliconazole is an antifungal medication used to treat certain types of fungal infections of the skin, such as athlete's foot (tinea pedis), jock itch (tinea cruris), and ringworm (tinea corporis). It belongs to a class of drugs known as azole antifungals. Luliconazole works by stopping the growth of fungi.

Luzu Cream (Luliconazole) is a topical antifungal cream that is used in the treatment of superficial fungal infections including athletes foot, jock itch, and ringworm.

Luliconazole Uses:

• Fungal infections:
  • It is applied topically to treat the fungi Trichophyton rubrum and Epidermophyton floccosum that cause interdigital tinea pedis (athlete's foot), tinea corporis (ringworm), and tinea cruris (Jock Itch).

Luliconazole (Luzu Cream) Dose in Adult:

Luliconazole (Luzu Cream) Dose in the treatment of Fungal infections: Topical:

Tinea pedis:

• Apply the medicine to the affected area (your foot) and the skin around it, covering about an inch around, once a day.
• Keep doing this every day for 2 weeks.

Tinea cruris or tinea corporis:

• Apply the medicine to the affected area (like your groin for jock itch) and the skin around it, covering about an inch around, once a day.
• Keep doing this every day for 1 week.

Use in Children:

Refer to adults dosing.

Pregnancy Risk Category: C

• In some studies, with animals, there were negative effects noticed during pregnancy when using luliconazole.
• Also, a small amount of the medicine can be absorbed into the body.

Luliconazole use during breastfeeding:

• We're not sure if luliconazole is found in breast milk.
• The manufacturer suggests that if you're breastfeeding and need to use this medicine, you should consider factors like the potential exposure of your baby to the medicine, the benefits of breastfeeding for your baby, and how important the treatment is for you.

Luliconazole Dose in Kidney Disease:

• The manufacturer's instructions don't include any changes in dosage for people with kidney problems.

Luliconazole Dose in Liver disease:

• The manufacturer's instructions do not mention any changes in dosage for individuals with liver issues.

Side effects of Luliconazole (Luzu Cream):

• Itching
• Burning
• stinging
• rendness
• cellulitis
• systemic signs of allergic reactions like fever, itching, hives, hypotension, and swelling of the lips and tongue.

Contraindications to Luliconazole (Luzu Cream):

• According to the manufacturer's information, there are no specific situations where the use of luliconazole is completely forbidden.

Warnings and precautions

Use it in the right way:

• Luliconazole is meant to be used only on the skin and should not be taken by mouth, used in the eyes, or inserted into the vagina.

Monitoring Parameters:

Monitor the response to treatment.

How to administer Luliconazole (Luzu Cream)?

• Luliconazole is strictly for applying on the skin and should never be used in the eyes, mouth, or vagina.
• When applying, cover the affected area and about an inch of the skin around it.
• Remember to wash your hands after applying it.

Mechanism of action of Luliconazole (Luzu Cream):

• Luliconazole belongs to a group of antifungal medications called azoles.
• It works by blocking an enzyme called lanosterol demethylase, which is involved in making ergosterol, a crucial component of fungal cell membranes.
• By inhibiting this enzyme, luliconazole reduces the production of ergosterol while increasing levels of lanosterol.
• This disruption weakens the fungal cell membrane, ultimately leading to the death of the fungus.

Absorption:

• After applying luliconazole to the skin, a small quantity might be absorbed into the body.

Protein binding:

• It mostly binds to proteins in the blood, specifically more than 99% of it attaches to plasma proteins.

International Brand Names of Luliconazole:

• Luzu
• Luconac
• Lulicon
• Lulifin

Luliconazole Brand Names in Pakistan:

No Brands Available in Pakistan.