The eye infections brought on by susceptible bacterial species are treated with ofloxacin eye drops and eye ointment.

Ofloxacin eye drops and Ointment Uses:

• Bacterial conjunctivitis:

  • Staphylococcus aureus, Proteus mirabilis, Streptococcus pneumoniae, Staphylococcus epidermidis, Enterobacter cloacae,
  • Haemophilus influenzae, and Pseudomonas aeruginosa are some of the bacteria that can cause bacterial conjunctivitis.

• Corneal ulcer:

  • Treatment of corneal ulcers brought on by Serratia marcescens, P. aeruginosa, S. aureus, S. epidermidis, S. pneumoniae, and Cutibacterium acnes.

Ofloxacin eye drops Dose in Adults

Ofloxacin eye drops Dose in the treatment of Bacterial conjunctivitis:

• Ophthalmic:
• Instill 1 to 2 drops into the affected eye(s) every 2 to 4 hours for the first 2 days, then 4 times daily for an additional 5 days.

Ofloxacin eye drops Dose in the treatment of Corneal ulcer:

• Ophthalmic:
• For the first two days, place 1 to 2 drops in the afflicted eye(s) every half-hour while awake and every 4 to 6 hours after retiring.
• Instill 1 to 2 drops per hour while awake starting on day 3 for an additional 4 to 6 days.
• Afterward, repeat 1-2 drops every 4 times until clinical cure.

Ofloxacin eye drops Dose in Childrens

Ofloxacin eye drops dose in the treatment of Bacterial conjunctivitis:

• Children and Adolescents:

  • Initial:
  • For the first two days, put 1 to 2 drops in the afflicted eye(s) every 2-4 hours (Days 1 and 2).
  • After that, for a further five days, provide 1-2 drops four times each day (Days 3 through 7)

Ofloxacin Eye Drops dose in the treatment of Corneal ulcer:

• Children and Adolescents:

  • Initial:

  • For the first two days, put 1 to 2 drops in the afflicted eye(s) every half-hour while you're up and every 4-6 hours at night (Days 1 and 2).
  • Then, for a further 4-6 days, administer 1-2 drops while awake every hour (Days 3 through 7 to 9).
  • After that, take 1 to 2 drops 4 times each day until you see a clinical improvement.

Pregnancy Risk Factor C

• Animal reproduction studies revealed certain unfavourable outcomes.
• Ofloxacin taken orally passes into the placenta (Giamarellou 1989).
• The effectiveness of ocular medicine drops applied topically is inferior to oral dosages.
• To reduce potential exposure to the foetus, pregnant women should use the minimum effective dose of ophthalmic agent.
• This is combined with punctual occlusion for 3-5 minutes after application.

Ofloxacin eye drops use during breastfeeding:

• Ofloxacin can enter breast milk when used orally.
• If ofloxacin is detected in breast milk following ocular applications, it is unknown.
• The manufacturer advises that you choose whether to cease nursing or stop using the medication.
• As there could be negative effects on nursing infants, this is taking the treatment of mothers into consideration.

Dose in Kidney Disease:

• In the manufacturer’s labeling, there are no dosage adjustments provided.
• However, due to limited systemic absorption, dosage modification is improbable.

Ofloxacin eye drops Dose in Liver Disease:

• In the manufacturer’s labeling, there are no dosage adjustments provided.
• However, dosage adjustment unlikely due to low systemic absorption.

Side effects of Ofloxacin Eye Drops and Ointment:

• Central Nervous System:

  • Dizziness
  • Foreign Body Sensation Of Eye

• Gastrointestinal:

  • Nausea

• Ophthalmic:

  • Blurred Vision
  • Burning Sensation Of Eyes
  • Conjunctivitis (Chemical)
  • Eye Discomfort
  • Eye Pain
  • Eye Pruritus
  • Eye Redness
  • Keratitis (Chemical)
  • Lacrimation
  • Photophobia
  • Stinging Of Eyes
  • Swelling Of Eye
  • Xerophthalmia

Contraindication to Ofloxacin Eye Drops and Ointment:

• Hypersensitivity to ofloxacin or other quinolones or any component in the formulation

Warnings and precautions

• Hypersensitivity reactions

  • With systemic quinolone therapy, anaphylaxis, anaphylactic shock, and uncommonly severe hypersensitivity events (some fatal) have been reported (some after the first dose).
  • Angioedema (laryngeal pharyngeal or facial edoema), cardiovascular failure, dyspnea, and loss of consciousness might accompany some reactions.
  • In the event that you have an allergic response, stop using the medication.

• Superinfection

  • Superinfections with fungi and bacteria might result after prolonged use.
  • You can start the appropriate alternate treatment if superinfection is detected.

• Tendon rupture and inflammation

  • The use of systemic quinolone antibiotics has been linked to tendon inflammation and rupture.
  • In comparison to systemic therapy, the exposure after ophthalmic delivery will be much lower.
  • Stop immediately if you feel any tendon inflammation or pain.

Monitoring parameters:

Monitor response to treatment and superimposed fungal infections in chronic users.

How to administer Ofloxacin eye drops and ointment?

• Use solely for ophthalmic purposes; do not inject.
• Avoid putting your fingers, the applicator's tip, or other surfaces in contact with your eyes.

Mechanism of action of Ofloxacin (Ophthalmic):

• Ofloxacin acts as a DNA gyrase inhibitor.
• The DNA's superhelical shape is preserved by the crucial bacterial enzyme DNA gyrase.
• For DNA transcription, replication, recombination, and transposition, DNA gyrase is necessary.

Absorption:

• Upon ophthalmic instillation, little is systemically absorbed.

Excretion:

• Urine

International Brands of Ofloxacin (Ophthalmic):

• Ocuflox
• APO-Ofloxacin
• Ocuflox
• PMS-Ofloxacin
• SANDOZ Ofloxacin
• Aflacin
• Dong Kang Ming
• Exocin
• Exocine
• Floxal
• Floxedol
• Floxsal
• Inoflox
• Ocuflox
• Oflacin
• Oflovid
• Oflox
• Ofloxin
• Ofus
• Ofven
• Operan
• Optiflox
• Otoflox
• Oxacin
• Poenflox
• Quinovid
• Tarivid
• Telbit
• Trafloxal
• Uniflox
• Vista
• Ximex Koniflox

Ofloxacin Eye Drops and Ointments Brand Names in Pakistan: