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Dear Readers! I started this blog when my daughter was in the NICU. She had ventriculitis. Her CSF report grew E.coli. But, she was injected Teicoplanin directly into her brain. The doctors made two errors here:

Teicoplanin is for gram-positive bacteria only. It does not treat E.coli.
Teicoplanin is not for intraventricular use. The manufacturer strongly discourage injecting Teicoplanin into the brain.

My daughter bled into the brain. She lived for another two years and ultimately died.

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Podofilox Topical (Condylox Gel, Solution) - Uses, Dose, Side effects

Topical Podofilox is available as gel and solution formulations. It is used topically to treat genital and perianal warts.

Podofilox Topical Uses:

Genital warts:
- Treatment of external genital warts
Perianal warts:
- Treatment of perianal warts (gel only)
Off Label Use of Podofilox in Adults:
- Molluscum contagiosum

Podofilox Topical Dose in Adults

Podofilox Topical Dose in the treatment of Genital warts:

Topical: Solution:
- Apply two times a day (morning and evening) for 3 days consecutively, then withhold treatment for 4 consecutive days.
- This cycle of treatment and treatment-interruption may be repeated up to four times until the healing of the lesions and no visible wart tissue is seen.
- The maximum dose is 0.5 ml daily (or less than 10 cm of wart tissue).
Note:
- The treatment may be discontinued after four treatment cycles if the response is incomplete. Alternative therapies may be tried in such cases.

Podofilox Topical Dose in the treatment of genital and perianal warts:

Topical: Gel:
- Apply two times a day (morning and evening) for 3 days consecutively, then withhold treatment for 4 consecutive days.
- This cycle of treatment and treatment-interruption may be repeated up to four times until the healing of the lesions and no visible wart tissue is seen.
- The maximum dose is 0.5 gms daily (or less than 10 cm of wart tissue).
Note:
- The treatment may be discontinued after four treatment cycles if the response is incomplete. Alternative therapies may be tried in such cases.

Podofilix Topical Dose in the treatment of Molluscum contagiosum (off-label):

Topical: Gel or solution:
- Apply two times a day (morning and evening) for 3 days consecutively, then withhold treatment for 4 consecutive days.
- This cycle of treatment and treatment-interruption may be repeated up to four times until the healing of the lesions.

Podofilox Topical use in Children:

The safety and efficacy of the drug have not been established in children.

Pregnancy risk category: C

Avoid using it during pregnancy [Ref].

Podofilox use during breastfeeding:

It is unknown if the drug has been in breastmilk.
It is unlikely that the infant will be exposed to it, as it is not absorbed systemically.

Dose in renal disease:

The manufacturer has not recommended any adjustment in the dose, however, since it is not absorbed systemically, adjustment in the dose is not necessary in patients with kidney disease.

Dose in liver disease:

The manufacturer has not recommended any adjustment in the dose, however, since it is not absorbed systemically, Adjustment in the dose is not necessary in patients with liver disease.

Common Side Effects of Podofilox Topical Gel:

Central Nervous System:
- Localized Burning
- Local Pain
Dermatologic:
- Skin Erosion
Hematologic & Oncologic:
- Local Hemorrhage
Local:
- Local Inflammation
- Local Pruritus

Less Common Side Effects Of Podofilox Topical gel:

Central Nervous System:
- Headache
Dermatologic:
- Stinging Of The Skin
- Erythema

Side Effects Of Podofilox Topical Solution:

Central Nervous System:
- Localized Burning
- Local Pain
Dermatologic:
- Skin Erosion
Local:
- Local Inflammation
- Local Pruritus

Contraindications to Podofilox Topical:

Allergies to the drug, or intolerance to any ingredient of the formulation

Warnings and precautions

Reactions to skin:
- It is possible for skin reactions to occur.
- Most skin reactions are mild or moderate in intensity.

Monitoring parameters:

Monitor the response to treatment (for adequate healing) and tolerability of the patient.

How to Use Topical Podofilox?

It is intended for topical use only. It should not be applied to warts present on mucous membranes.
Wash hands before and after applying the drug.
Apply the drug using a finger (gel formulation only) or the applicator supplied with the drug (gel and solution).
Minimize exposure to the surrounding structures and normal tissue.
After applying the drug, dispose-off the applicator tip carefully.
Allow the solution or gel to dry in air.
Wash hands after applying the drug.