The flavoprotein enzymes required for typical tissue respiration include riboflavin as one of their constituents. It is necessary for the pyridoxine activation process as well as the conversion of tryptophan to niacin.

It is used as a dietary supplement and as off-label use in the prevention of migraine headaches.

It is included in the WHO's list of essential medicines.

Riboflavin (Vitamin B2) Dose in Adults

Use as a Dietary supplement:

• • 100 mg orally once or two times a day

Dose as off-label use in the Prevention of migraine headache:

• • 400 mg orally once a day.

Riboflavin (Vitamin B2) Dose in Childrens

Use as a Dietary supplement:

• Infants, Children, and Adolescents:
  • It is usually prescribed as a multivitamin preparation in pediatric patients.
  • The use of riboflavin alone is very rare.
  • When used as a single-ingredient, product labeling must be consulted.

Riboflavin dose in the prevention of Migraine headache:

• Children older than 8 years and Adolescents:
  • 200 - 400 mg orally once a day.

Pregnancy Risk category A

• It is a water-soluble Vitamin and can cross the placental Barrier.
• During pregnancy, requirements increase.

Use during breastfeeding:

• It can be found in breast milk.
• Supplements and maternal deficiencies can influence the concentration of riboflavin.
• Nursing women have a higher need than those who are not nurses.

Riboflavin (Vitamin B2) Dose in Renal Disease:

• Patients with renal dysfunction do not require dose adjustment.

Riboflavin (Vitamin B2) Dose in Liver Disease:

• Patients with hepatic dysfunction do not require dose adjustment.

Side Effects of Riboflavin (Vitamin B) include:

• Genitourinary:
  • Urine discoloration (yellow-orange)

Contraindication to Riboflavin (Vitamin B) includes:

There is no contraindication to the use of Riboflavin (Vitamin B2), however, a single vitamin deficiency is rare and the patient must be evaluated for other deficiency states.

Monitor:

Non required.

How to administer Riboflavin (Vitamin B2)?

It should be administered orally with food.

Mechanism of action of Vitamin B2 (Riboflavin):

• It is a crucial part of the flavoprotein enzymes needed for regular tissue respiration.
• Both the activation of pyridoxine and the conversion of tryptophan to niacin depend on it.

Absorption is increased by increasing food intake. 

It is growing rapidly and absorbed through the gastrointestinal tract.

It is metabolized it is responsible for the maintenance of the body's health.

A half-life between 66 and 84 minutes

International Brands of Riboflavin (Vitamin B2):

• B-2-400
• Vitamin B2Injektopas
• Vitaminum B2
• Arcavit-B2
• B2-ASmedic
• Vitamin B2 Streuli[Ampullen]
• Vitamin B2 Streuli[Tab.]
• Beflavine
• Berivine
• Bi-Love-G
• Bisanorin
• Bisulase
• Bituvitan
• Bonabon B!2
• Butirid
• Dalivit
• Eyekas
• Flavitol
• Hibon
• Vitamin B2 Jenapharm
• Vitamin B2 Jenapharm[inj.]
• Lacflavin
• Liperox
• Multiscleran
• Ribobis
• Ribobutin
• Ribon
• Riboract
• Vita-B2
• Vitamin B2
• Wakaflavin-L
• Werdo

Riboflavin (Vitamin B2) Brands in Pakistan:

No Brands Available in Pakistan.