Sertaconazole is an antifungal medicine that is used topically over the affected areas of the skin for the treatment of superficial fungal infections.

Uses:

• Tinea pedis:

  • Topical treatment of interdigital tinea pedis in immunocompetent patients 12 years of age and older, caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.

• Off Label Use of Sertaconazole in Adults:

  • Cutaneous candidiasis;
  • Seborrheic dermatitis;
  • Tinea versicolor

Sertaconazole Dose in Adults

Sertaconazole Dose in the treatment of Tinea pedis:

• Apply topically between toes and to surrounding healthy skin two times a day for 4 weeks

Sertaconazole Dose in the treatment of Cutaneous candidiasis (off-label):

• Topical: Apply to the affected area(s) two times a day for four weeks.

Dose in the treatment of Seborrheic dermatitis (off-label):

• Topical: Apply to the affected area(s) two times a day for 4 weeks.

Sertaconazole Dose in the treatment of Tinea versicolor (off-label):

• Apply topically to the affected area(s) two times a day for four weeks.

Sertaconazole Dose in Childrens

Sertaconazole dose in the treatment of Diaper dermatitis caused by candida: Limited data available:

• Infants and Children 2 to 24 months:

  • Apply topically twice a day for 2 weeks.

Sertaconazole dose in the treatment of Tinea corporis:

• Children ≥2 years and Adolescents:

  • Apply topically once a day for two weeks;

Sertaconazole dose in the treatment of Tinea pedis:

• Children ≥12 years and Adolescents:

  • Apply topically between toes and to the surrounding healthy skin two times a day for 4 weeks.

Pregnancy Risk Factor C

• In animal reproduction studies, adverse events following oral administration were not observed.

Use during breastfeeding:

• It is unknown if the drug is found in breast milk.
• It is recommended that lactating mothers be cautious when using it.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to minimal systemic absorption.

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment unlikely due to minimal systemic absorption.

Side Effects of Sertaconazole:

• Dermatologic:

  • Burning sensation of skin
  • Contact dermatitis
  • Skin tenderness
  • Xeroderma

Contraindications to Sertaconazole:

The manufacturer's labeling does not list any contraindications.

Warnings and precautions

• Irritation

  • If irritation is observed at the application site or hypersensitivity reactions occur, the treatment should be stopped immediately.

Sertaconazole: Drug Interaction

Monitoring parameters:

The patient's condition should be reassessed after two weeks if no or minimal improvement is noted.

How to administer Sertaconazole?

It is applied over the affected area of the skin two times a day. The affected area should be cleaned and dried before applying the medicine.

Mechanism of action of Sertaconazole:

It blocks the CYP450-dependent synthesis ergosterol, resulting in the death of the fungi by altering the cell wall permeability.

Absorption:

• After topical application, absorption is minimal. The serum concentration of the drug is below the limit for quantitation (2.5ng/mL).

International Brand Names of Sertaconazole:

• Ertaczo
• Dermofix
• Dermofix Gyno Ovule
• Fixitazol
• Fuganol
• Gyno-Zalain
• Konzert
• Monazol
• Onabet
• Sertacream
• Zalain
• Zalain Cream

Sertaconazole Brand Names in Pakistan:

No Brands Available in Pakistan.