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Dear Readers! I started this blog when my daughter was in the NICU. She had ventriculitis. Her CSF report grew E.coli. But, she was injected Teicoplanin directly into her brain. The doctors made two errors here:

Teicoplanin is for gram-positive bacteria only. It does not treat E.coli.
Teicoplanin is not for intraventricular use. The manufacturer strongly discourage injecting Teicoplanin into the brain.

My daughter bled into the brain. She lived for another two years and ultimately died.

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TNF Inhibitors for Rheumatoid Arthritis

TNF inhibitors are now widely used for the treatment of Rheumatoid arthritis. These drugs act by inhibiting the action of TNF that is involved in activating inflammatory cells and cytokines in patients with Rheumatoid arthritis.

TNF inhibitors are used as monotherapy or in combination with conventional biological DMARDs such as methotrexate for the treatment of moderate to severely active RA.

Using TNF inhibitors for the treatment of RA may offer some benefits compared to methotrexate:

TNF Inhibitors have a relatively faster onset of action compared to methotrexate
Most TNF inhibitors are categorized as pregnancy category B drugs and are considered very safe compared to methotrexate which is contraindicated in pregnancy.
TNF inhibitors are more potent and have the potential of achieving disease remission in a greater percentage of RA patients compared to methotrexate.
These drugs can be used as monotherapy or in combination with other drugs in moderate and severely active RA.

However, using TNF inhibitors for Rheumatoid Arthritis may increase the risks of serious infections including mycobacterial and fungal infections. In addition, these drugs are very costly compared to conventional DMARDs such as methotrexate.

List of TNF Inhibitors for Rheumatoid Arthritis:

A list of TNF inhibitors for RA is given in the table below.

TNF Inhibitors for RA	Date of Approval
Etanercept	2nd Nov 1998
Infliximab	11th Nov 1999
Adalimumab	31st December 2002
Certolizumab	22nd April 2008
Golimumab	24th April 2009

Although, the efficacy of all TNF inhibitors has been found comparable, here is a table demonstrating some differences between the various TNF inhibitors:

Medication	Brand Name	Route of Administration	Dosage Form	Dosage Frequency	Approved Indications
Etanercept	Enbrel	Subcutaneous Injection	Prefilled Syringe or Autoinjector	Weekly	Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Juvenile Idiopathic Arthritis
Infliximab	Remicade	Intravenous Infusion	Vial	Every 4-8 Weeks	Rheumatoid Arthritis, Crohn's Disease, Ulcerative Colitis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis
Golimumab	Simponi	Subcutaneous Injection	Prefilled Syringe or Autoinjector	Every 4 Weeks	Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Ulcerative Colitis
Certolizumab	Cimzia	Subcutaneous Injection	Prefilled Syringe or Autoinjector	Every 2-4 Weeks	Rheumatoid Arthritis, Psoriatic Arthritis, Crohn's Disease
Adalimumab	Humira	Subcutaneous Injection	Prefilled Syringe or Autoinjector	Every 1-2 Weeks	Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Crohn's Disease, Ulcerative Colitis, Psoriasis, Juvenile Idiopathic Arthritis

In Conclusion:

In conclusion, TNF inhibitors are effective for treating rheumatoid arthritis. They have been shown to significantly reduce joint inflammation and pain, and slow down joint damage in patients.

However, it's important to weigh the benefits and potential risks of TNF inhibitors, as these drugs can have side effects and are not suitable for everyone. Despite their potential risks, TNF inhibitors have been a significant advancement in the treatment of rheumatoid arthritis, and have helped improve the quality of life for countless patients.

TNF Inhibitors for Rheumatoid Arthritis

List of TNF Inhibitors for Rheumatoid Arthritis:

Medication

Brand Name

Route of Administration

Dosage Form

Dosage Frequency

Approved Indications

In Conclusion:

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