Tetrahydrozoline is a medication commonly used as a nasal decongestant. It works by constricting blood vessels in the nasal passages, which helps to reduce swelling and congestion. It's often found in over-the-counter nasal sprays or drops intended to relieve stuffy noses due to colds or allergies. However, it's essential to use tetrahydrozoline nasal spray or drops as directed, as overuse can lead to dependence and rebound congestion.

Tyzine (Tetrahydrozoline Nasal Spray) is a sympathomimetic drug that causes vasoconstriction of the blood vessels. It is used as a nasal spray for the relief of nasal congestion associated with allergies.

Tyzine (Tetrahydrozoline Nasal Spray) Uses:

• It is used for the symptomatic treatment of nasal congestion.

Tyzine (Tetrahydrozoline Nasal Spray) Dose in Adults

Tyzine (Tetrahydrozoline Nasal Spray) Dose in the treatment of Nasal congestion:

• When using tetrahydrozoline for nasal congestion, you typically apply 2 to 4 drops or 3 to 4 sprays of a 0.1% solution into each nostril.
• You can do this every 3 to 4 hours as needed, but not more often than every 3 hours.

Tyzine (Tetrahydrozoline Nasal Spray) Dose in Children

Tyzine (Tetrahydrozoline Nasal Spray) Dose in the therapy of Nasal congestion: Intranasal:

Children 2-6 years:

• The usual dose of tetrahydrozoline for nasal congestion is 2 to 3 drops of a 0.05% solution into each nostril.
• You can do this every 4 to 6 hours as needed, but not more often than every 3 hours.

Children >6 years: Refer to adult dosing.

Pregnancy Risk Factor C

• Tetrahydrozoline has been categorized as Pregnancy Risk Factor C, meaning there haven't been specific studies on its effects during pregnancy in animals.
• This classification suggests that while there's no direct evidence of harm, there's also a lack of comprehensive research to confirm its safety for pregnant individuals.

Tetrahydrozoline Dose in Liver disease:

The manufacturer has made no recommendations on dose changes.

Tetrahydrozoline Dose in Liver disease:

The manufacturer has made no recommendations on dose changes.

Side Effects of Tyzine (Tetrahydrozoline Nasal Spray):

• Ophthalmic:
  • Blurred vision
• Respiratory:
  • Sneezing
  • Stinging sensation of the nose

• Central nervous system:
  • Headache
• Cardiovascular:
  • Tachycardia
  • Hypertension
  • Palpitations
• Neuromuscular & skeletal:
  • Tremor

Contraindications to Tyzine (Tetrahydrozoline Nasal Spray):

• If someone has an allergy to tetrahydrozoline or any ingredient in the product, they shouldn't use it.
• Additionally, the 0.5% solution shouldn't be used in children younger than 2 years old, and the 0.1% solution shouldn't be used in children younger than 6 years old.
• These age restrictions are put in place to ensure the safety of children and to avoid potential adverse effects.

Warnings and precautions

Somnolence

• In children, taking too much tetrahydrozoline can lead to severe drowsiness.
• This might also come with sweating, low blood pressure, or even shock.
• It's crucial not to go over the recommended doses to prevent these serious side effects.

Cardiovascular disease

• If you have cardiovascular issues like high blood pressure or coronary artery disease, be cautious when using tetrahydrozoline.

Endocrine disorders:

• If you have endocrine disorders such as diabetes or hyperthyroidism, it's important to be cautious when using tetrahydrozoline.

Tetrahydrozoline (nasal): Drug Interaction

Monitoring parameters:

Monitoring Blood Pressure and Heart Rate

• Keep an eye on your blood pressure and heart rate while using tetrahydrozoline.
• Pay attention to how you feel and any changes in symptoms like congestion.
• If you notice anything unusual, contact your healthcare provider promptly.

How to administer Tyzine (Tetrahydrozoline Nasal Spray)?

• It is administered intranasally.
• The patient should blow the nose and clean it before use.
• The tip of the spray should be inserted into the nostril while the other nostril is blocked.
• The medicine is sprayed into the nostril and the patient asked to keep breathing with the same nostril for a brief time.

Mechanism of action of Tyzine (Tetrahydrozoline Nasal Spray):

• Tetrahydrozoline stimulates alpha-adrenergic receptors in the blood vessels of the nasal lining.
• This stimulation causes the blood vessels to constrict, reducing swelling and congestion in the nasal passages.

The beginning of action

• It typically takes about 4 to 8 hours for the decongestant effect of tetrahydrozoline to kick in.
• During this time, you may start to experience relief from nasal congestion.

International Brands of Tetrahydrozoline Nasal Spray:

• Tyzine

Tetrahydrozoline Brand Names in Pakistan:

No Brands Available in Pakistan.