Biopsy Not Needed for Diagnosing Celiac Disease!

Author: Dr. Ahmed Farhan     Published: 8 months ago 0 Replies

Serum anti-tissue transglutaminase IgA (tTG-IgA) levels can reliably diagnose celiac disease without the need for a diagnostic bowel biopsy in adults without IgA deficiency.

This approach has a high positive predictive value (95.9%) and sensitivity (98%) when serum tTG-IgA concentrations are greater than 10 times the upper limit of normal.

The authors of the study published in the Lancet Gastroenterology and Hepatology recommended a No-Biopsy approach in patients without IgA deficiency and highly positive celiac serology 

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