I think there are no guidelines to answer your question. The clinician and cardiologist should both discuss the situation and decide about the continuation or discontinuation of antiplatelets in such cases.

• It is best to stop dual antiplatelets when the platelet counts drop to less than 50000/ul.
• A single antiplatelet drug, preferably Clopidogrel, may be initiated in patients with platelet counts above 50000/ul.
• Dual antiplatelets can be continued if platelets counts exceed 100000/ul.
• However, in patients who are at high risk of bleeding, all antiplatelets can be discontinued if the platelet counts are less than 100000/ul.

If the patient has minor bleeding, the patient may just be monitored and platelet transfusions should be withheld. In a major bleeding episode, platelets should be transfused regardless of the history of angioplasty, myocardial infarction, or platelet counts.