What are the ultra-short acting insulin?
How rapidly they lower the blood glucose when administered subcuataneously?
Ultra short acting Insulins (Subcutaneous)
| Insulin | Onset | Peak | Effective |
| Lispro | 5-15 min | 1-1.5 hrs | 3-4 hrs |
| Aspart | 5-15 min | 1-1.5 hrs | 3-4 hrs |
| Glulisine | 5-15 min | 1-1.5 hrs | 3-4 hrs |
Reference:
1) Current Medical Diagnosis & Treatment. 2020
NEWER Ultra short acting Insulins (Subcutaneous)
| Insulin | Onset | Peak | Effective |
| Lispro-aabc (Lyumjev) | 15-17 min | 2-2.5 hrs | 4-6 hrs |
| Faster aspart | 5 min | 50 min |
Reference:
1) Lyumjev prescribing information. Available on: These highlights do not include all the information needed to use LYUMJEV safely and effectively. See full prescribing information for LYUMJEV.LYUMJEV (insulin lispro-aabc) injection, for subcutaneous or intravenous useInitial U.S. Approval: 2020 (lilly.com) [Accessed: July 07, 2021]
2) Fath M, Danne T, Biester T, Erichsen L, Kordonouri O, Haahr H. Faster‐acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus. Pediatric diabetes. 2017 Dec;18(8):903-10.