NOACs or Warfarin in Frail patients with atrial fibrillation

Author: Dr. Ahmed Farhan     Published: 9 months ago 0 Replies

NOACs (novel oral anticoagulants) or DOACs (direct oral anticoagulants) are considered safe alternatives to VKAs ( vitamin k antagonists) like warfarin.

However, in a recent trial conducted in Frail Elderly Individuals with atrial fibrillation, switching from VKAs to NOACs resulted in a 69% increased risk of bleeding in the NOACs group (Frail-AF Trial).

Because NOACs are relatively new drugs and data regarding its safety in elderly patients with multiple comorbid conditions, polypharmacy, and bleeding risks is not sufficient.

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