Irbesartan and hydrochlorothiazide are two different drugs often used in combination to treat high blood pressure (hypertension). When used together, they can be more effective than either drug used alone.
Irbesartan and hydrochlorothiazide (Avalide, Coaprovel) is a combination pill containing angiotensin receptor blocker and a thiazide diuretic. It is used in the treatment of patients with hypertension, heart failure, and nephrotic syndrome.
Irbesartan and hydrochlorothiazide Uses
- Hypertension:
- It is indicated primarily for the treatment of hypertension.
Irbesartan and hydrochlorothiazide dose in adults:
Irbesartan and hydrochlorothiazide (Avalide, Coaprovel) Dose in the treatment of Hypertension: Oral:
For treating high blood pressure:
- It might take 2 to 4 weeks to see the full benefits of this medicine. But, if needed, the dose can be changed after just 1 week.
- If someone is already taking either irbesartan or hydrochlorothiazide but it's not working well, they can switch to a combo pill.
- The starting dose is usually a combo of irbesartan 150 mg with hydrochlorothiazide 12.5 mg, taken once daily.
- If that doesn't work well, the dose can be increased after 1 to 2 weeks. The highest dose allowed is irbesartan 300 mg with hydrochlorothiazide 25 mg per day.
Irbesartan and hydrochlorothiazide Dose in Children:
It is not indicated for use in children.
Pregnancy Risk Factor D
- [Important Warning]: Medicines like these can harm or even cause death to an unborn baby.
- If you find out you're pregnant, stop taking the medicine right away.
- Always check details on individual drugs too.
Use of irbesartan or hydrochlorothiazide during breastfeeding
- Water pills like hydrochlorothiazide are found in breast milk.
- It's unclear if irbesartan gets into breast milk.
- Because there might be risks for the baby, you should decide either to stop breastfeeding or stop taking the medicine.
- Think about how important the medicine is for the mom.
- Always check details on individual drugs.
Irbesartan and hydrochlorothiazide Dose in Kidney Disease:
If your kidneys filter more than 30 mL/min:
- No need to change the medicine dose, but be careful.
If your kidneys filter 30 mL/min or less:
- It's best not to use the medicine.
- The water pill part (hydrochlorothiazide) probably won't work well.
Irbesartan and hydrochlorothiazide Dose in Liver Disease:
Adjustment in the dose is not necessary. Use with caution in patients with advanced liver disease.
Side Effects of Irbesartan and hydrochlorothiazide (Avalide, Coaprovel):
- Cardiovascular:
- Edema
- Chest Pain
- Decreased Blood Pressure
- Tachycardia
- Central Nervous System:
- Dizziness
- Fatigue
- Endocrine:
- Hypokalemia
- Gastrointestinal:
- Nausea And Vomiting
- Dyspepsia
- Heartburn
- Abdominal Pain
- Genitourinary:
- Difficulty In Micturition
- Neuromuscular & Skeletal:
- Musculoskeletal Pain
- Renal:
- Increased Blood Urea Nitrogen
- Increased Serum Creatinine
- Miscellaneous:
- Flu-Like Symptoms
Contraindications to Irbesartan and hydrochlorothiazide (Avalide, Coaprovel):
Don't use this medicine if:
- You're allergic to irbesartan, hydrochlorothiazide, medicines derived from sulfonamides, or any part of this drug.
- You're taking aliskiren and have diabetes.
- You can't produce urine.
Heads Up: There's a debate on whether this medicine should be avoided with other drugs containing sulfonamides. For more on this, see the “Warnings/Precautions” section.
For Canadians: There are more reasons to avoid this medicine:
- Don't take with aliskiren if your kidneys are not working well (GFR <60 mL/min/1.73 m^2).
- Don't take with ACE inhibitors if you have kidney issues related to diabetes.
- Avoid during pregnancy and breastfeeding.
- Don't use if you have rare genetic issues with processing certain sugars like galactose.
Warnings and precautions
Angioedema
- Some people taking ARBs, a kind of blood pressure medicine, have reported swelling, especially after the first dose.
- This swelling can happen anywhere but can be dangerous if it's around the head and neck (it might block breathing) or in the belly (causing pain).
- If you've had swelling issues before, especially with ACE-inhibitors, or have a family history of it, be extra cautious.
- If you get swelling in areas like your tongue or throat, which can block your airway, you need to be watched closely. If you've had throat surgery, you might be more at risk.
- Stop the medicine right away if swelling happens. Act fast to treat it. In severe cases, a shot of epinephrine might be needed.
- If you've had swelling from ARBs before, don't take them again.
Electrolyte disturbances:
- ARBs (like the one in this medicine) can cause high potassium levels. This risk goes up if you have kidney problems, diabetes, or are taking other medicines or supplements with potassium. Be careful when mixing these, and regularly check your potassium levels.
- The water pill part of this medicine can lead to low potassium, low chloride, low magnesium, and low sodium.
Keep an eye on your electrolyte levels when taking this medication.
Gout
- If you've had gout before, if gout runs in your family, or if you have long-term kidney problems, the water pill part (hydrochlorothiazide) might trigger a gout attack.
- This risk goes up with doses 25 mg or more.
Hypersensitivity reactions
- Some people might have allergic reactions to the water pill (hydrochlorothiazide).
- If you've had allergies or asthma before, you're more likely to react.
- Be cautious.
Hypotension
- Starting this medicine might cause low blood pressure, especially in people who are low on body fluids or salt (like those taking strong water pills).
- Make sure you're well-hydrated before starting.
- If you experience low blood pressure, it doesn't mean you can't continue the medicine.
Ocular effects
- The water pill (hydrochlorothiazide) can cause sudden nearsightedness or a type of glaucoma quickly after starting it.
- If you notice sudden vision changes or eye pain, stop the medicine right away.
- You might need more treatments if eye pressure stays high.
- People allergic to sulfonamides or penicillin might be more at risk.
Photosensitivity
- This medicine can make you more sensitive to sunlight.
- Be careful when out in the sun.
Renal function deterioration:
- This medicine might harm the kidneys, especially in people with certain kidney issues or heart failure.
- Symptoms can include reduced urine, sudden kidney failure, or rising waste products in the blood.
- A small increase in a blood test for kidney function (serum creatinine) might happen after starting.
- If the kidneys get much worse while on this medicine, think about stopping it.
Allergy to sulfonamide ("sulfa")
- Some medicines have a "sulfa" group in them. People allergic to these might be told to avoid all sulfa-related drugs.
- It used to be thought that if you're allergic to one sulfa drug, you might react to all. But newer info suggests this isn't always true.
- Allergic reactions to sulfa antibiotics might not mean you'll react to non-antibiotic sulfa drugs. The risk seems very low.
- Still, if you had a very bad reaction to a sulfa drug in the past (like a severe rash), some doctors might play it safe and avoid all sulfa drugs for you.
Mitral and aortic stenosis:
- If you have major narrowing of the aortic or mitral heart valves, be careful when using this medicine.
Bariatric surgery
- Don't take water pills right after weight-loss (bariatric) surgery.
- They can cause dehydration and mess with your body's salt balance.
- You can start taking them again once you're drinking enough fluids (as guided by your doctor).
Diabetes:
- If you have diabetes or are at risk for it, be careful with the water pill (hydrochlorothiazide).
- It might affect your blood sugar levels.
Hepatic impairment
- Be careful using this medicine if you have serious liver problems.
- If your liver disease gets worse, there's a risk of imbalances that might cause confusion or coma.
Hypercalcemia:
- The water pill part (thiazide diuretics) can reduce how much calcium the kidneys get rid of.
- If you have high calcium levels, think about not using this medicine.
Hypercholesterolemia:
- Be careful using this medicine if you have moderate or high cholesterol.
- The water pill part (thiazides) can raise cholesterol and fat (triglyceride) levels in the blood.
Parathyroid disease
- The water pill part (thiazide diuretics) can make the body hold onto more calcium.
- Long-term use might change the parathyroid glands and lead to high calcium and low phosphate in the blood.
- Stop this medicine before testing for parathyroid function.
Renal artery stenosis
- Be careful with irbesartan if you have narrowing in one or both kidney arteries and don't have stents.
- If both arteries are affected without stents, it's usually best to avoid this medicine.
- It might harm kidney function unless the benefits are really worth the risks.
Renal impairment
- If you have kidney problems, be careful with irbesartan.
- The water pill part (hydrochlorothiazide) can make some kidney issues worse, like increased waste products in the blood.
Systemic lupus erythematosus (SLE):
- The water pill (hydrochlorothiazide) can make lupus worse or even trigger it.
Irbesartan and hydrochlorothiazide: Drug Interaction
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Ajmaline |
Sulfonamides may enhance the adverse/toxic effect of Ajmaline. Specifically, the risk for cholestasis may be increased. |
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Alcohol (Ethyl) |
May enhance the orthostatic hypotensive effect of Thiazide and Thiazide-Like Diuretics. |
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Alfuzosin |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Allopurinol |
Thiazide and Thiazide-Like Diuretics may enhance the potential for allergic or hypersensitivity reactions to Allopurinol. Thiazide and Thiazide-Like Diuretics may increase the serum concentration of Allopurinol. Specifically, Thiazide Diuretics may increase the concentration of Oxypurinol, an active metabolite of Allopurinol. |
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Aminolevulinic Acid (Topical) |
Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Topical). |
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Amphetamines |
May diminish the antihypertensive effect of Antihypertensive Agents. |
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Angiotensin II |
Receptor Blockers may diminish the therapeutic effect of Angiotensin II. |
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Anticholinergic Agents |
May increase the serum concentration of Thiazide and Thiazide-Like Diuretics. |
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Antidiabetic Agents |
Thiazide and Thiazide-Like Diuretics may diminish the therapeutic effect of Antidiabetic Agents. |
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Antidiabetic Agents |
Hyperglycemia-Associated Agents may diminish the therapeutic effect of Antidiabetic Agents. |
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Antipsychotic Agents (Second Generation [Atypical]) |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Antipsychotic Agents (Second Generation [Atypical]). |
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Barbiturates |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Benperidol |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Beta2-Agonists |
May enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics. |
|
Brigatinib |
May diminish the antihypertensive effect of Antihypertensive Agents. Brigatinib may enhance the bradycardic effect of Antihypertensive Agents. |
|
Brimonidine (Topical) |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
|
Calcium Salts |
Thiazide and Thiazide-Like Diuretics may decrease the excretion of Calcium Salts. Continued concomitant use can also result in metabolic alkalosis. |
|
CarBAMazepine |
Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of CarBAMazepine. Specifically, there may be an increased risk for hyponatremia. |
|
Cardiac Glycosides |
Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cardiac Glycosides. Specifically, cardiac glycoside toxicity may be enhanced by the hypokalemic and hypomagnesemic effect of thiazide diuretics. |
|
Corticosteroids (Orally Inhaled) |
May enhance the hypokalemic effect of Thiazide and ThiazideLike Diuretics. |
|
Corticosteroids (Systemic) |
May enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics. |
|
Cyclophosphamide |
Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Cyclophosphamide. Specifically, granulocytopenia may be enhanced. |
|
CycloSPORINE (Systemic) |
Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of CycloSPORINE (Systemic). |
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Dapoxetine |
May enhance the orthostatic hypotensive effect of Angiotensin II Receptor Blockers. |
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Dexketoprofen |
May enhance the adverse/toxic effect of Sulfonamides. |
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Dexmethylphenidate |
May diminish the therapeutic effect of Antihypertensive Agents. |
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Diacerein |
May enhance the therapeutic effect of Diuretics. Specifically, the risk for dehydration or hypokalemia may be increased. |
|
Diazoxide |
Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Diazoxide. |
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Diazoxide |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Dichlorphenamide |
Thiazide and Thiazide-Like Diuretics may enhance the hypokalemic effect of Dichlorphenamide. |
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Drospirenone |
Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of Drospirenone. |
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DULoxetine |
Blood Pressure Lowering Agents may enhance the hypotensive effect of DULoxetine. |
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Eplerenone |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Heparin |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Heparins (Low Molecular Weight) |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Herbs (Hypertensive Properties) |
May diminish the antihypertensive effect of Antihypertensive Agents. |
|
Herbs (Hypotensive Properties) |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Hypotension-Associated Agents |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Hypotension-Associated Agents. |
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Ipragliflozin |
May enhance the adverse/toxic effect of Thiazide and Thiazide-Like Diuretics. Specifically, the risk for intravascular volume depletion may be increased. |
|
Ivabradine |
Thiazide and Thiazide-Like Diuretics may enhance the arrhythmogenic effect of Ivabradine. |
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Levodopa-Containing Products |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Levodopa-Containing Products. |
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Licorice |
May enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics. |
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Lormetazepam |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Methenamine |
Thiazide and Thiazide-Like Diuretics may diminish the therapeutic effect of Methenamine. |
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Methylphenidate |
May diminish the antihypertensive effect of Antihypertensive Agents. |
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Molsidomine |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Multivitamins/Fluoride (with ADE) |
May enhance the hypercalcemic effect of Thiazide and Thiazide-Like Diuretics. |
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Multivitamins/Minerals (with ADEK, Folate, Iron) |
Thiazide and Thiazide-Like Diuretics may enhance the hypercalcemic effect of Multivitamins/Minerals (with ADEK, Folate, Iron). |
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Multivitamins/Minerals (with AE, No Iron) |
Thiazide and Thiazide-Like Diuretics may increase the serum concentration of Multivitamins/Minerals (with AE, No Iron). Specifically, thiazide diuretics may decrease the excretion of calcium, and continued concomitant use can also result in metabolic alkalosis. |
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Naftopidil |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Neuromuscular-Blocking Agents (Nondepolarizing) |
Thiazide and Thiazide-Like Diuretics may enhance the neuromuscular-blocking effect of Neuromuscular-Blocking Agents (Nondepolarizing). |
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Nicergoline |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Nicorandil |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Nicorandil |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Nitroprusside |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Nitroprusside. |
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Nonsteroidal Anti-Inflammatory Agents |
Thiazide and Thiazide-Like Diuretics may enhance the nephrotoxic effect of Nonsteroidal Anti-Inflammatory Agents. Nonsteroidal Anti-Inflammatory Agents may diminish the therapeutic effect of Thiazide and Thiazide-Like Diuretics. |
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Nonsteroidal Anti-Inflammatory Agents |
Angiotensin II Receptor Blockers may enhance the adverse/toxic effect of Nonsteroidal Anti-Inflammatory Agents. Specifically, the combination may result in a significant decrease in renal function. Nonsteroidal Anti-Inflammatory Agents may diminish the therapeutic effect of Angiotensin II Receptor Blockers. The combination of these two agents may also significantly decrease glomerular filtration and renal function. |
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Opioid Agonists |
May enhance the adverse/toxic effect of Diuretics. Opioid Agonists may diminish the therapeutic effect of Diuretics. |
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OXcarbazepine |
Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of OXcarbazepine. Specifically, there may be an increased risk for hyponatremia. |
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Pentoxifylline |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Pholcodine |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Pholcodine. |
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Phosphodiesterase 5 Inhibitors |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Porfimer |
Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. |
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Potassium Salts |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Potassium-Sparing Diuretics |
Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of Potassium-Sparing Diuretics. |
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Prostacyclin Analogues |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Quinagolide |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. |
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Ranolazine |
May enhance the adverse/toxic effect of Angiotensin II Receptor Blockers. |
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Reboxetine |
May enhance the hypokalemic effect of Thiazide and Thiazide-Like Diuretics. |
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Selective Serotonin Reuptake Inhibitors |
May enhance the hyponatremic effect of Thiazide and Thiazide-Like Diuretics. |
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Tacrolimus (Systemic) |
Angiotensin II Receptor Blockers may enhance the hyperkalemic effect of Tacrolimus (Systemic). |
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Tolvaptan |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Toremifene |
Thiazide and Thiazide-Like Diuretics may enhance the hypercalcemic effect of Toremifene. |
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Trimethoprim |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. |
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Valsartan |
HydroCHLOROthiazide may enhance the hypotensive effect of Valsartan. Valsartan may increase the serum concentration of HydroCHLOROthiazide. |
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Verteporfin |
Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. |
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Vitamin D Analogs |
Thiazide and Thiazide-Like Diuretics may enhance the hypercalcemic effect of Vitamin D Analogs. |
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Yohimbine |
May diminish the antihypertensive effect of Antihypertensive Agents. |
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Risk Factor D (Consider therapy modification) |
|
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Aliskiren |
May enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Aliskiren may enhance the hypotensive effect of Angiotensin II Receptor Blockers. Aliskiren may enhance the nephrotoxic effect of Angiotensin II Receptor Blockers. Management: Aliskiren use with ACEIs or ARBs in patients with diabetes is contraindicated. Combined use in other patients should be avoided, particularly when CrCl is less than 60 mL/min. If combined, monitor potassium, creatinine, and blood pressure closely. |
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Amifostine |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Amifostine. Management: When amifostine is used at chemotherapy doses, blood pressure lowering medications should be withheld for 24 hours prior to amifostine administration. If blood pressure lowering therapy cannot be withheld, amifostine should not be administered. |
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Angiotensin-Converting Enzyme Inhibitors |
|
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Bile Acid Sequestrants |
May decrease the absorption of Thiazide and Thiazide-Like Diuretics. The diuretic response is likewise decreased. |
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Lithium |
Thiazide and Thiazide-Like Diuretics may decrease the excretion of Lithium. |
|
Lithium |
Angiotensin II Receptor Blockers may increase the serum concentration of Lithium. Management: Lithium dosage reductions will likely be needed following the addition of an angiotensin II receptor antagonist. |
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Obinutuzumab |
May enhance the hypotensive effect of Blood Pressure Lowering Agents. Management: Consider temporarily withholding blood pressure lowering medications beginning 12 hours prior to obinutuzumab infusion and continuing until 1 hour after the end of the infusion. |
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Sodium Phosphates |
Angiotensin II Receptor Blockers may enhance the nephrotoxic effect of Sodium Phosphates. Specifically, the risk of acute phosphate nephropathy may be enhanced. Management: Consider avoiding this combination by temporarily suspending treatment with ARBs, or seeking alternatives to oral sodium phosphate bowel preparation. If the combination cannot be avoided, maintain adequate hydration and monitor renal function closely. |
|
Sodium Phosphates |
Diuretics may enhance the nephrotoxic effect of Sodium Phosphates. Specifically, the risk of acute phosphate nephropathy may be enhanced. Management: Consider avoiding this combination by temporarily suspending treatment with diuretics, or seeking alternatives to oral sodium phosphate bowel preparation. If the combination cannot be avoided, hydrate adequately and monitor fluid and renal status. |
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Topiramate |
Thiazide and Thiazide-Like Diuretics may enhance the hypokalemic effect of Topiramate. Thiazide and Thiazide-Like Diuretics may increase the serum concentration of Topiramate. Management: Monitor for increased topiramate levels/adverse effects (e.g., hypokalemia) with initiation/dose increase of a thiazide diuretic. Closely monitor serum potassium concentrations with concomitant therapy. Topiramate dose reductions may be necessary. |
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Risk Factor X (Avoid combination) |
|
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Aminolevulinic Acid (Systemic) |
Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Systemic). |
|
Bromperidol |
Blood Pressure Lowering Agents may enhance the hypotensive effect of Bromperidol. Bromperidol may diminish the hypotensive effect of Blood Pressure Lowering Agents. |
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Dofetilide |
HydroCHLOROthiazide may enhance the QTc-prolonging effect of Dofetilide. HydroCHLOROthiazide may increase the serum concentration of Dofetilide. |
|
Fexinidazole [INT] |
Thiazide and Thiazide-Like Diuretics may enhance the arrhythmogenic effect of Fexinidazole [INT]. |
|
Levosulpiride |
Thiazide and Thiazide-Like Diuretics may enhance the adverse/toxic effect of Levosulpiride. |
|
Mecamylamine |
Sulfonamides may enhance the adverse/toxic effect of Mecamylamine. |
|
Promazine |
Thiazide and Thiazide-Like Diuretics may enhance the QTc-prolonging effect of Promazine. |
Monitoring Parameters:
Blood Pressure
- Measure regularly to ensure the medication is working.
- Monitor for any sudden drops or spikes.
Serum Electrolytes
- Check levels like sodium, potassium, and chloride.
- Ensure they are in the normal range.
BUN (Blood Urea Nitrogen)
- Measures how much urea nitrogen is in the blood.
- Helps check kidney function.
Creatinine
- Another way to check kidney health.
- Monitor to ensure kidneys are working properly.
How to administer Irbesartan and hydrochlorothiazide (Avalide, Coaprovel)?
How to Take:
- You can take this medicine with food or on an empty stomach.
Mechanism of action of Irbesartan and hydrochlorothiazide (Avalide, Coaprovel):
Irbesartan:
- It blocks a chemical called angiotensin II, which causes blood vessels to narrow.
- It also stops aldosterone release, which leads to less salt and water being retained.
- Overall, it helps lower blood pressure.
Hydrochlorothiazide:
- It stops the kidneys from reabsorbing too much sodium and water.
- This leads to more sodium, water, potassium, and hydrogen being passed out in urine.
Remember, check details for each drug separately.
International Brand Names of Irbesartan and hydrochlorothiazide:
- Avalide
- ACT Irbesartan/HCT
- Apo-Irbesartan/HCTZ
- Avalide
- Irbesartan-HCT
- Irbesartan-HCTZ
- JAMPIrbesartan and Hydrochlorothiazide
- Mint-Irbesartan/HCTZ
- PMS-Irbesartan HCTZ
- Ran-Irbesartan HCTZ
- ratio-Irbesartan HCTZ
- Sandoz-Irbesartan HCT
- Teva-Irbesartan HCTZ
- Andaran HTC
- Aprozide
- Arbitan PLUS
- Avalide
- Avapro HCT
- CoAprovel
- Co-Besartin
- Co-Irvebal
- Co-Ivyzar
- CoApprovel
- Coaprovel
- CoAprovel
- Corycardon
- Ibef
- Ifirmacombi
- Ihybes-G
- Irbemed PLus
- Irbeprex H
- Irbezyd-H
- Irbis-HT
- Irovel-H
- Irtan Plus
- Karvezide
- KoIrbesso
Irbesartan and hydrochlorothiazide Brand Names In Pakistan:
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Irbesartan and hydrochlorothiazide 150 mg Tablets in Pakistan |
|
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Arbi-D |
Pharmevo (Pvt) Ltd. |
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Co-Aprovel |
Sanofi Aventis (Pakistan) Ltd. |
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Co-Arbista |
Sante (Pvt) Limited |
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Hyponorm-H. |
Werrick Pharmaceuticals |
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Irecon-H |
Barrett Hodgson Pakistan (Pvt) Ltd. |
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Zepose Plus |
Wilshire Laboratories (Pvt) Ltd. |
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Irbesartan and hydrochlorothiazide 300 mg Tablets in Pakistan |
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Arbi-D |
Pharmevo (Pvt) Ltd. |
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Co-Aprovel |
Sanofi Aventis (Pakistan) Ltd. |
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Co-Arbista Forte |
Sante (Pvt) Limited |
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Hyponorm-H. |
Werrick Pharmaceuticals |
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Irecon-H |
Barrett Hodgson Pakistan (Pvt) Ltd. |
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Zepose Plus |
Wilshire Laboratories (Pvt) Ltd. |
 Injection.webp)