Sodium biphosphate, phenyl salicylate, methylene blue, and hyoscyamine are all ingredients of the drug uribel. It relieves irritative bladder symptoms associated with urinary tract infections or local diagnostic procedures.

Methenamine, sodium biphosphate, phenyl salicylate, methylene blue, and hyoscyamine Uses:

• It is used to treat localized symptoms of urinary tract infections as well as urinary tract symptoms brought on by diagnostic urologic procedures. It is intended for the treatment of irritative symptoms experienced during voiding.

Uribel Dose in Adults:

Uribel Dose in the treatment of Urinary tract symptoms:

• One tablet administered orally 4 times a day (It should be followed by liberal fluid intake)

Uribel Dose in Children:

Uribel Dose in the treatment of Urinary tract symptoms:

• Children >6 years:

  • Oral: Individualize the dose. Refer to adult dosing.

Pregnancy Risk Factor C

• This combination has not been used in animal reproduction studies.
• Methenamine and hyoscyamine cross the placental barrier (see individual agents)

Methenamine, sodium diphosphate, and phenyl salicylate are all available for breastfeeding.

• Breast milk contains hyoscyamine and methenamine.
• It is recommended that you use it with caution if you are lactating.

Uribel Dose in Kidney disease:

• There are no dosage adjustments provided in the manufacturer's labeling.
• It should be used with caution as it contains methenamine which is contraindicated in advanced renal impairment.
• However, the methenamine quantity (in mg) is very less compared to the single ingredient.

Uribel Dose in Liver disease:

• There are no dosage adjustments provided in the manufacturer's labeling.
• It should be used with caution in patients with advanced liver disease.
• Methenamine is contraindicated in advanced liver disease.
• However, the combination product contains very little amount compared to the single ingredient.

Side effects of Uribel:

• Respiratory:

  • Dyspnea

• Central nervous system:

  • Dizziness

• Cardiovascular:

  • Flushing
  • Tachycardia

• Ophthalmic:

  • Blurred vision

• Gastrointestinal:

  • Xerostomia
  • Nausea
  • Vomiting

• Genitourinary:

  • Acute urinary retention
  • Urine discoloration (blue)
  • Difficulty in micturition

Contraindications to Uribel

• Hypersensitivity to methenamine or hyoscyamine, or any other component of the formulation.

Notice: Hyoscyamine and methenamine contraindications may also be applicable

Warnings and precautions

• Belladonna alkaloid allergy:

  • Patients who have a history of intolerance or hypersensitivity to belladonna alkaloids need to be cautious.

• Blurred vision

  • The treatment should be stopped if the patient has blurred vision.

• Dizziness:

  • If dizziness develops, the treatment should be stopped.

• Salicylate allergy

  • Patients who have a history of intolerance should be cautious when using salicylates.

• Cardiovascular disease

  • Patients with cardiovascular disease, such as those who are at high risk of heart attack, heart failure, coronary disease, mitral stenosis, or cardiac arrhythmias, should use it with caution.

• Tachycardia

  • If tachycardia develops, the treatment should be stopped immediately.

• Gastrointestinal tract obstruction:

  • It can reduce intestinal motility. Patients with obstruction of the gastrointestinal tract should not use it.

• Glaucoma:

  • Glaucoma patients should be advised to avoid it.

• Myasthenia gravis:

  • Patients suffering from myasthenia gravis need to be cautious.

• Obstructive Uropathy:

  • Patients with urinary obstructions such as bladder neck obstruction and prostatic hyperplasia should not use it.

Monitoring Parameters:

• Monitor for anticholinergic side effects including cardiac arrhythmias.
• Observe the clinical features of intestinal obstruction such as nausea, abdominal pain, and bloating.

How to administer Uribel?

Administer the drug two to four times a day without regard to meals or preferably after meals with plenty of water.

Pharmacology and  Mechanism of action of Uribel?

It is a combination of five different drugs with analgesic, antispasmodic, and anticholinergic properties.

See each drug for detailed MOA:

• Methenamine
• Hyoscyamine (Levsin)
• Methylene Blue Dye

International Brands:

• Phosphasal
• Utira-C
• Utrona-C
• Vilamit MB
• Vilevev MB
• Ur N-C
• Uramit MB
• Urelle
• Uretron D/S
• Azuphen MB
• Hyolev MB
• Uribel
• Urimar-T
• Urin DSUro-MP
• UroAv-81
• UroAv-B
• Ustell
• Uro-458
• Uro-L
• Uticap

Methenamine, sodium biphosphate, phenyl salicylate, methylene blue, and hyoscyamine Brand Names in Pakistan:

No Brands Available in Pakistan.