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Teicoplanin is for gram-positive bacteria only. It does not treat E.coli.
Teicoplanin is not for intraventricular use. The manufacturer strongly discourage injecting Teicoplanin into the brain.

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Tekturna (Aliskiren) - Uses, Indications, Warnings

Tekturna (Generic name: Aliskiren) belongs to the class of drugs called "direct renin inhibitors".

Tekturna Uses:

Hypertension is treated using it. Despite utilising other medications, it may be utilised to treat proteinuria in those with type 2 diabetes mellitus, hypertension, and nephropathy.

(Tekturna) Aliskiren and Valsartan:

It has been studied in combination with valsartan for the treatment of hypertension. At the maximum recommended doses, it was found to be superior to monotherapy with either of the drugs and was well tolerated [Ref].

Aliskiren and Losartan in Type 2 Diabetes with nephropathy:

Aliskiren (Tekturna) has been studied in patients with diabetes type 2 in combination with losartan. The authors concluded that aliskiren may have renoprotective effects that are independent of its blood pressure lowering effects in patients with diabetes, hypertension, and nephropathy [Ref].

(Tekturna) Aliskiren and Enalapril in heart failure:

Aliskiren given in combination with an ACE inhibitor like enalapril in patients with heart failure may be hazardous. It was studied in patients with heart failure and reduced ejection fraction. The authors of the study concluded that patients in the combination group were more likely to have hypotensive episodes, raised creatinine levels, and hyperkalemia [Ref].

Tekturna Contraindications

Patients with the following conditions are not recommended:

Hypersensitivity to the formulation
Patients with diabetes mellitus should not take an ACE inhibitor or ARB concurrently.
Angioedema: History
Angioedema idiopathic or hereditary

Precautions and Warnings from Tekturna

Patients who use a direct renin inhibiter are at greater risk of hyperkalemia, especially if they have predisposing factors such as diabetes mellitus, kidney failure, patients taking potassium-sparing diuretics or ACE inhibitors.
Angioedema and anaphylaxis have been reported.
Volume depleted patients may develop hypotension.
It is best to not use strong inhibitors of Pglycoprotein (eg cyclosporine, itraconazole) concurrently.

Tekturna Dose in Adults

Tekturna Dosage:

Take 150 mg once daily to start. The dosage can be raised up to 300 mg once daily.

Tekturna Dosage in Children:

For youngsters (20 kg to 50 kg) with high blood pressure, the initial dose is either 37.5 mg or 75 mg once day. The highest dose that is advised is 150 mg.

Aliskiren dose in Kidney disease:

In patients with renal impairment, use with caution.
With a creatinine clearance of less than 30 mL/min, dose modification is not required.
Due to the possibility of developing hyperkalemia, it should only be administered with the utmost caution in patients with ESRD and a creatinine clearance of less than 30 ml/min. Perhaps no dose modification is required.

Aliskiren dose in liver disease:

No dosage adjustment is necessary.

How to take the drug?

It may best be taken with meals at the same time of the day.

Aliskiren Pregnancy Risk Factor X

[U.S.-Bound Warning]

Aliskiren should, along with other drugs that affect the renin/angiotensin systems, be stopped immediately after pregnancy is confirmed.
The unborn foetus may suffer harm or even pass away as a result.
In many cases, oligohydramnios, which can result in foetal lung hypoplasia and skeletal abnormalities, is linked to direct renin inhibitors like
Aliskiren or other medications that affect on the renin-angiotensin systems.
Additionally, hypotension, anuria, and renal failure may be related to it. You can find it in breast milk. It is not suggested that you use it when you are pregnant.

Tekturna Side effects:

Common side effects include

Diarrhoea, hyperkalemia, arthralgia, and vertigo The following adverse effects are also treatable if the medication is stopped: anaemia, angioedema, erythema, peripheral edoema, coughing, pruritus, rash, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, and renal failure (reversible with treatment cessation).

Monitorinf Parameters

Blood pressure; serum potassium, BUN, and serum creatinine

Aliskiren (Tekturna) Mechanism of Action:

Aliskiren is a direct renin inhibitor that blocks renin, thus inhibiting the whole pathway of the renin-angiotensin-aldosterone system.
Angiotensin II, the main hormone responsible to elevating blood pressure through vasoconstriction is also responsible for stimulating the production aldosterone in the adrenal cortex.
Within 2 weeks, the maximum antihypertensive effect can be seen.

Absorption isPoor, especially when combined with a high-fat diet.

Metabolism: Unknown extent of metabolismIn vitroStudies show that metabolism is controlled by CYP3A4.

Bioavailability is approximately3%

Elimination of Half-lifeIt takes approximately 24 hours (ranging between 16-32 hours).

Peak plasma concentration can be reached at a certain time.It takes 1-3 hours

ExcretionIt is excreted through urine and feces. About 25% of the dose absorbed is excreted unchanged by the urine.

Aliskiren Brand Names (International):

Enviage
Rasilez
Sprimeo
Tekturna

ALEVIA (ATCO LABORATORIES LIMITED)

Tablet: 300 mg

1 tablet pack : Rs. 117.00

Tablet: 150 mg

7 tablets pack ; Rs. 490.00

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

ALLDAY (WERRICK PHARMACEUTICALS)

Tablet: 300 mg

1 tablet pack : Rs. 117.00

Tablet: 150 mg

7 tablets pack ; Rs. 490.00

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

ASILEZ (EFROZE CHEMICAL INDUSTRIES (PVT) LTD)

Tablet: 150 mg

7 tablets pack ; Rs. 490.00

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

EASRIN (DON VALLEY PHARMACEUTICALS (PVT) LTD)

Tablet: 150 mg

7 tablets pack ; Rs. 490.00

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

MASILEZ (MAPLE PHARMACEUTICALS (PVT) LTD)

Tablet: 150 mg

1 tablets pack ; Rs. 117

Tablet: 150 mg :

20 tablets pack : Rs. 449

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

RASILEZ (NOVARTIS PHARMA (PAK) LTD)

Tablet: 150 mg

7 tablets pack ; Rs. 490.00

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

SKIREN (GETZ PHARMA PAKISTAN (PVT) LTD)

Tablet: 150 mg

7 tablets pack ; Rs. 490.00

Tablet: 300 mg

7 tablets pack ; Rs. 819.00

AKSILEZ-V (CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD)

Tablets : Aliskiren : 150 mg , Valsartan : 160 mg

14 tablets pack : Rs. 1100.00

7 tablets pack : Rs. 550.00

ALEVIA-V (ATCO LABORATORIES LIMITED)

Tablets : Aliskiren : 150 mg , Valsartan : 160 mg

14 tablets pack : Rs. 1100.00

7 tablets pack : Rs. 550.00

Tablets : Aliskiren : 300 mg , Valsartan : 320 mg

14 tablets pack : Rs. 1834

7 tablets pack : Rs. 917

ALLDAY-H (WERRICK PHARMACEUTICALS)

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

10 tablets pack ; Rs. 652.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

10 tablets pack ; Rs. 652.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

10 tablets pack ; Rs. 1087.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

10 tablets pack ; Rs. 1087.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 1521.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 1521.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

20 tablets pack ; Rs. 1239.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

20 tablets pack ; Rs. 1239.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

20 tablets pack ; Rs. 2065.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

20 tablets pack ; Rs. 2065.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

28 tablets pack ; Rs. 1735.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

28 tablets pack ; Rs. 1735.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

28 tablets pack ; Rs. 2890.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

28 tablets pack ; Rs. 2890.00

CO-KIREN (TABROS PHARMA)

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 1521.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 1521.00

ERIN (GENIX PHARMA (PVT) LTD)

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 1521.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 1521.00

RENRID (GLOBAL PHARMACEUTICALS)

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

28 tablets pack ; Rs. 1735.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

20 tablets pack ; Rs. 1239.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

10 tablets pack ; Rs. 652.00

RENRID H (GLOBAL PHARMACEUTICALS)

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

28 tablets pack ; Rs. 1735.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

20 tablets pack ; Rs. 1239.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

10 tablets pack ; Rs. 652.00

SKIREN PLUS (GETZ PHARMA PAKISTAN (PVT) LTD)

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

10 tablets pack ; Rs. 652.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

10 tablets pack ; Rs. 1087.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 913.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

14 tablets pack ; Rs. 1521.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

14 tablets pack ; Rs. 1521.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

20 tablets pack ; Rs. 1239.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

20 tablets pack ; Rs. 1239.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

20 tablets pack ; Rs. 2065.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

20 tablets pack ; Rs. 2065.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 12.5 mg :

28 tablets pack ; Rs. 1735.00

Tablets : Aliskiren : 150 mg , Hydrochlorothiazide : 25 mg :

28 tablets pack ; Rs. 1735.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 12.5 mg :

28 tablets pack ; Rs. 2890.00

Tablets : Aliskiren : 300 mg , Hydrochlorothiazide : 25 mg :

28 tablets pack ; Rs. 2890.00

Tekturna (Aliskiren) - Uses, Indications, Warnings

Tekturna Uses:

(Tekturna) Aliskiren and Valsartan:

Aliskiren and Losartan in Type 2 Diabetes with nephropathy:

(Tekturna) Aliskiren and Enalapril in heart failure:

Tekturna Contraindications

Tekturna Dose in Adults

Tekturna Dosage:

Tekturna Dosage in Children:

Aliskiren dose in Kidney disease:

Aliskiren dose in liver disease:

How to take the drug?

Aliskiren Pregnancy Risk Factor X

[U.S.-Bound Warning]

Tekturna Side effects:

Monitorinf Parameters

Aliskiren (Tekturna) Mechanism of Action:

Aliskiren Brand Names (International):

ALEVIA (ATCO LABORATORIES LIMITED)

ALLDAY (WERRICK PHARMACEUTICALS)

ASILEZ (EFROZE CHEMICAL INDUSTRIES (PVT) LTD)

EASRIN (DON VALLEY PHARMACEUTICALS (PVT) LTD)

MASILEZ (MAPLE PHARMACEUTICALS (PVT) LTD)

RASILEZ (NOVARTIS PHARMA (PAK) LTD)

SKIREN (GETZ PHARMA PAKISTAN (PVT) LTD)

AKSILEZ-V (CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD)

ALEVIA-V (ATCO LABORATORIES LIMITED)

ALLDAY-H (WERRICK PHARMACEUTICALS)

CO-KIREN (TABROS PHARMA)

ERIN (GENIX PHARMA (PVT) LTD)

RENRID (GLOBAL PHARMACEUTICALS)

RENRID H (GLOBAL PHARMACEUTICALS)

SKIREN PLUS (GETZ PHARMA PAKISTAN (PVT) LTD)

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