Amoxicillin (Amoxil) Dose, Indications, Side effects

Amoxicillin is a beta-lactam antibiotic used to treat a variety of infections that include mostly Gram-Positive organisms and anaerobic bacterial organisms. Amoxicillin dose may vary in different infections. These factors include:

  • The severity of infection
  • The site of infection, and
  • The bacterial organism causing the infection.

Amoxicillin is indicated for the treatment of the following infections:

  • ENT infections like pharyngitis, tonsillitis, and otitis media in patients aged 12 years of age or more, caused by:
    • Beta-lactamase-negative Streptococcus spp
    • Streptococcus pneumoniae,
    • Staphylococcus spp., or
    • Haemophilus influenzae.
    • Streptococcus pyogenes
  • Genitourinary tract infections caused by:
    • Beta-lactamase-negative Escherichia coli
    • Proteus mirabilis
    • Enterococcus faecalis.
  • Helicobacter pylori eradication in combination therapy in patients with a duodenal ulcer
  • Lower respiratory tract infections like pneumonia and bronchitis caused by:
    • Beta-lactamase-negative Streptococcus spp.
    • S. pneumoniae,
    • Staphylococcus spp., or
    • H. influenzae.
  • Acute bacterial rhinosinusitis caused by:
    • Betalactamase-negative Streptococcus spp.
    • S. pneumoniae,
    • Staphylococcus spp.
    • H. influenzae.
  • Skin and soft tissue infections caused by:
    • Beta-lactamase-negative Streptococcus spp.
    • Staphylococcus spp.
    • E. coli.
  • Actinomycosis, Anthrax, and prophylaxis against bacterial infection in high-risk patients
  • Bronchiectasis, Prophylaxis of bacterial endocarditis, Lyme disease, Generalized Aggressive Periodontitis, and Prosthetic joint infection.

Amoxicillin Dose in Adults

The usual amoxicillin dose:

  • Immediate-release: 500 mg to 1 g twice or thrice daily
  • Extended-release: 775 mg once daily

Off-label use in the treatment of Actinomycosis:

Note: Severe infections should be treated with intravenous formulation followed by oral. Less severe infections may be treated with oral amoxicillin.

  • Oral amoxicillin: 500 mg thrice or four times a day. Higher doses of 4 to 6 g daily have been used in case reports. Treatment duration depends on the severity and extent of the disease and may vary from 2 - 12 months.

Penicillin-susceptible strains of Anthrax:

Inhalational exposure and post-exposure prophylaxis: Oral amoxicillin 1 gm thrice daily for 60 days.

Cutaneous anthrax:1 gm orally thrice daily for 60 days (following infections acquired via biological weapons), and 10 days following naturally acquired infection.

Note: Public health specialists should be consulted. Exposed individuals should be administered anthrax vaccine.


Amoxicillin dose in the prevention of bacterial infections in high-risk patients with asplenia:

  • 500 mg orally twice daily.

Amoxicillin dose in Bronchiectasis:

  • Treatment of pulmonary exacerbations: 500 mg to 1000 mg thrice daily for 14 days.
  • Prevention of pulmonary exacerbations (in patients with more than 3 exacerbations per year who are not colonized with pseudomonas aeruginosa: 500 mg orally twice daily.

Amoxicillin dose for the prophylaxis of endocarditis (prior to dental or invasive respiratory tract procedures):

  • 2 gms 30 to 60 minutes before the procedure.

Amoxicillin dose in the eradication of Helicobacter pylori infection:

  • Clarithromycin triple regimen:

    • Amoxicillin 1 g twice daily for 14 days in combination with clarithromycin 500 mg twice daily, plus a standard-dose or double-dose proton pump inhibitor.
  • Concomitant regimen:

    • Amoxicillin 1 g twice daily for 14 days in combination with clarithromycin 500 mg twice daily, either tinidazole or metronidazole 500 mg twice daily, plus a standard-dose proton pump inhibitor twice daily.
  • Sequential regimen:

    • Amoxicillin 1 gm twice daily plus a standard-dose proton pump inhibitor twice daily for 7 days; followed by clarithromycin 500 mg twice daily and either metronidazole or tinidazole 500 mg twice daily, plus a standard-dose proton pump inhibitor twice daily for 5 - 7 days.
  • Hybrid regimen:

    • Amoxicillin 1 g twice daily plus a proton pump inhibitor twice daily for 14 days. Add clarithromycin 500 mg twice daily and either metronidazole or tinidazole 500 mg twice daily after 7 days of therapy for 7 days.
  • Levofloxacin triple regimen (salvage regimen):

    • Amoxicillin 1 g twice daily in combination with levofloxacin 500 mg once daily and a standard-dose proton pump inhibitor twice daily for 10 to 14 days.
  • The Salvage regimen (High-dose dual therapy):

    • Amoxicillin 750 mg 4 times a day or 1 gm thrice daily in combination with a proton pump inhibitor 3 to 4 times daily for 14 days

Off label use in Lyme disease:

  • Patients with early and localized disease (eg, erythema migrans):

    • 500 mg thrice daily for 14 to 21 days
  • Patients with disseminated disease (carditis and neurologic involvement without meningitis):

    • 500 mg thrice daily for 21 days.
  • Late disease with arthritis & without neurologic involvement:

    • 500 mg 3 times daily for 28 days

Amoxicillin dose in Otitis media:

  • 500 mg thrice daily or 875 mg every twice daily for 7 to 10 days. Amoxicillin/clavulanic acid may be preferred over amoxicillin)

Amoxicillin dose in generalized aggressive periodontitis:

  • 250 to 500 mg thrice daily in combination with metronidazole for 14 days (Wilder 2018)

Amoxicillin dose in community-acquired pneumonia (CAP):

  • 1000 mg thrice daily in combination with other appropriate medicines like macrolides for a minimum of five days. Therapy may be discontinued when the patient is afebrile for at least two days (IDSA/ATS [Mandell 2007).

Prosthetic joint infection:

For chronic suppression of bacterial growth in patients (who are not candidates for removal of the prosthesis) with infected prosthetic joints caused by beta-hemolytic streptococci, penicillin-susceptible Enterococcus spp., or Cutibacterium spp.

Amoxicillin dose in Acute bacterial Rhinosinusitis:

  • 500 mg thrice daily or 875 mg twice daily for 7 days in patients aged less than 65 years and without any risk factors like diabetes and an immunocompromised state.

Amoxicillin dose in Skin and soft tissue infection:

  • Mild Erysipelas:
    • 500 mg thrice daily or
    • 875 mg twice daily for 5 to 14 days (longer duration may be used in patients with more severe infection or in immunosuppressed individuals).

Amoxicillin dose for Group A Streptococcal pharyngitis:

  • 500 mg twice daily or 1 g once daily for 10 days (AHA [Gerber 2009]
  • Extended-release: 775 mg once daily for 10 days

Amoxicillin dose in Urinary tract infection:

  • Cystitis due to Enterococcus spp.:

    • 500 mg thrice daily or 875 mg twice daily for 5 days (Murray 2018).
  • Asymptomatic group B Streptococcus bacteriuria in pregnancy:

    • 500 mg thrice daily or
    • 875 mg twice daily for 3 to 7 days.

Amoxicillin Dose in Children

Amoxicillin usual dose in Children for susceptible infection:

  • Mild to moderate infection:

    • Infants less than 3 months of age:
      • 25 to 50 mg/kg/day in three divided doses every 8 hours
    • Infants older than 3 months of age, Children, and Adolescents:
      • 25 to 50 mg/kg/day in three divided doses (maximum dose is 500 mg/dose)
  • Severe infection:

Amoxicillin dose in Anthrax:

  • Cutaneous anthrax:

    • Infants, Children, and Adolescents:
      • 75 mg/kg/day in divided doses administered 8 hourly for 10 days (infection acquired naturally) to 60 days Infection acquired as a victim of biological weapon). (Maximum dose is 1,000 mg/dose)
  • Post-exposure prophylaxis after inhalational exposure:

    • Infants, Children, and Adolescents:
    • 75 mg/kg/day in three divided doses for 60 days after exposure. (Maximum dose is 1,000 mg/dose).

Amoxicillin dose in Catheter infection (peritoneal dialysis):

  • Infants, Children, and Adolescents:
    • 10 to 20 mg/kg once daily to a maximum dose of 1,000 mg/dose.

Amoxicillin dose for prophylaxis of bacterial endocarditis:

(Prophylaxis of endocarditis should be limited to high-risk patients and those with potential adverse outcomes including:

  • Prosthetic heart valves
  • Patients with previous IE
  • Patients with unrepaired cyanotic congenital heart disease
  • Those with repaired congenital heart disease during the first six months after the procedure or with prosthetic material
  • Repaired congenital heart disease (with residual defects)
  • Heart transplant recipients with cardiac valvulopathy.
  • Infants, Children, and Adolescents:
    • 50 mg/kg 30 to 60 minutes prior to the procedure (maximum dose is 2,000 mg/dose)

Helicobacter pylori eradication therapy:

  • Children and Adolescents:
    • 50 mg/kg/day in twice daily for 14 days (in combination with a proton pump inhibitor or bismuth subsalicylate and either clarithromycin or metronidazole)

Amoxicillin dose in Lyme disease:

  • Infants, Children, and Adolescents:
    • 50 mg/kg/day in three divided doses to a maximum dose of 500 mg/dose

Amoxicillin dose in acute Otitis media:

Amoxicillin dose in Community-acquired Pneumonia:

  • Infants older than 3 months, Children, and Adolescents (empiric therapy):

    • 90 mg/kg/day in two divided doses to a maximum daily dose of 4,000 mg/day
  • Mild infection caused by Group A Streptococcus:

    • 50 to 75 mg/kg/day in two divided doses to a maximum of 4000 mg per day
  • Mild infection caused by Haemophilus influenzae:

    • 75 to 100 mg/kg/day in three divided doses to a maximum of 4 gms daily
  • Mild infection caused by Streptococcus pneumonia (penicillin MIC ≤2 mcg/mL):

    • 90 mg/kg/day in two divided doses every 12 hours or
    • 45 mg/kg/day in three divided doses every 8 hours
    • The maximum daily dose is 4,000 mg/day

Prophylaxis of pneumococcal infection in patients with functional or anatomic asplenia:

  • 2 months to 5 years of age:

    • 20 mg/kg/day in two divided doses every 12 hours to a maximum dose of 250 mg/dose.
  • Children older than 6 years of age and Adolescents:

    • 250 mg every 12 hours

Amoxicillin dose in acute uncomplicated bacterial rhinosinusitis:

  • Children older than 2 years and Adolescents:
    • 45 mg/kg/day in two divided doses
    • 80 to 90 mg/kg/day in two divided doses to a maximum dose of 2000 mg/dose for moderate to severe infections

Amoxicillin dose for the treatment of Tonsillopharyngitis caused by Group A streptococcal infection and prevention of rheumatic fever:

  • Children and Adolescents 3 to 18 years:
    • 50 mg/kg once daily or 25 mg/kg twice daily for 10 days to a maximum dose of 1 gm daily.
    • 775 mg extended-release formulation once daily may be given to children 12 years of age or more.

Prophylaxis of UTI in patients with hydronephrosis and vesicoureteral reflux:

  • Infants 2 months of age or less:
    • 10 to 15 mg/kg once daily in the evening.

Pregnancy Risk Factor B

  • Amoxicillin crosses the placenta, however, teratogenic effects have not been observed in animal and human studies.
  • Rare case reports of cleft lip and cleft palate have been observed.
  • Amoxicillin may be used to treat anthrax in pregnancy, management of PROM, prophylaxis of endocarditis, and as an alternative treatment of chlamydial infection.

Amoxicillin use in Breastfeeding

  • Although amoxicillin is excreted in breast milk, it is generally considered acceptable.
  • Allergic reactions, thrush, and diarrhea due to altered bowel flora in infants must be monitored.
  • Amoxicillin may also be used to treat mastitis and anthrax in breastfeeding women.    

Amoxicillin Dose in Renal Disease:

  • Immediate-release oral formulation:

    • Avoid the 875 mg dose in patients with an eGFR of less than 30 ml/min.
    • Creatinine clearance of 30 mL/minute or more:

      • Dose adjustment is not necessary.
    • Creatinine clearance of 10 to 30 mL/minute:

      • 250 to 500 mg twice daily
    • Creatinine clearance of less than 10 mL/minute:

      • 250 to 500 mg once daily
    • Hemodialysis:

      • Amoxicillin is moderately dialyzable. The dose should be administered after dialysis on the dialysis day: 250 to 500 mg once daily.
  • Extended-release oral formulation:

    • CrCl of 30 mL/minute or more:

      • No dosage adjustment is necessary according to the manufacturer's labeling.
    • CrCl of less than 30 mL/minute:

      • Not recommended
    • Hemodialysis:

      • Not recommended.

Amoxicillin Dose in Liver Disease:

The manufacturer has not advised any dose adjustment in patients with liver disease.

 

Frequent side effects of amoxicillin:

  • Central nervous system:

    • Headache
  • Gastrointestinal:

    • Diarrhea, nausea, and vomiting.
  • Genitourinary:

    • Vulvovaginal infection

Rare side effects of amoxicillin:

  • Cardiovascular:

    • Hypersensitivity angiitis
  • Central nervous system:

    • anxiety, behavioral changes, confusion, dizziness, insomnia, hyperactivity, and seizure
  • Dermatologic:

    • Acute generalized exanthematous pustulosis, erythematous maculopapular rash, exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, and urticaria.
  • Gastrointestinal:

    • C.difficile associated diarrhea/ colitis, hemorrhagic colitis, melanoglossia, and mucocutaneous candidiasis
  • Genitourinary:

    • Crystalluria
  • Hematologic & oncologic:

    • Agranulocytosis, anemia, eosinophilia, hemolytic anemia, immune thrombocytopenia, thrombocytopenia, and leukopenia.
  • Hepatobiliary:

    • Cholestatic jaundice, hepatitis (acute cytolytic), increased serum ALT and AST.
  • Hypersensitivity:

    • Anaphylaxis
  • Immunologic:

    • Serum sickness-like reaction

Contraindications to amoxicillin:

  • Severe allergic reactions (like anaphylaxis, Steven-Johnson syndrome or TEN) to amoxicillin or any component of the formulation.
  • Other beta-lactams can cause serious hypersensitivity reactions
  • Cases of infectious mononucleosis suspected or confirmed.

Warnings and Precautions

  • Superinfection:

    • Amoxicillin prolonged use can lead to the growth of bacteria and fungi.
    • Of importance are C.difficile-associated diarrhea and pseudomembranous colitis following prolonged (more than 2 months) use of amoxicillin.
  • Infectious mononucleosis

    • Amoxicillin may cause a rash in patients with IM.
    • Patients with CMV infection or Acute Lymphoblastic Leukemia may experience rash after amoxicillin is taken.
  • Renal impairment

    • Patients with impaired renal function (eGFR less than 30ml/min) should not use it.
    • Patients with ESRD or those on hemodialysis should avoid extended-release formulations.

Amoxicillin: Drug Interaction

Note: Drug Interaction Categories:

  • Risk Factor C: Monitor When Using Combination
  • Risk Factor D: Consider Treatment Modification
  • Risk Factor X: Avoid Concomitant Use

Risk Factor C (Monitor therapy).

Acemetacin Penicillins may increase serum levels
Allopurinol Amoxicillin might make allergic or hypersensitive reactions more likely.
BCG Vaccine (Immunization) Antibiotics can decrease the therapeutic effects of BCG Vaccine (Immunization).
Lactobacillus & Estriol Antibiotics can reduce the therapeutic effects of Lactobacillus or Estriol.
Methotrexate Methotrexate serum concentrations could be increased by penicillins
Mycophenolate The serum levels of Mycophenolate's active metabolites can be lowered by penicillins. Impaired enterohepatic circulation could be to blame for this.
Vitamin K antagonists (eg warfarin) Vitamin K Antagonists can be enhanced by penicillins.

Risk Factor D (Insist on therapy modification)

 
Probenecid Increases the serum level of Penicillins. Management: Penicillins should not be combined with probenecid. However, this combination can be beneficial in certain cases and under careful supervision. If probenecid is given or if the dose is increased, monitor for potential toxic effects.
Sodium Picosulfate Antibiotics can reduce the therapeutic effects of Sodium Picosulfate. Patients who are currently using or have just finished using antibiotics should consider using an alternative product to cleanse the bowels before undergoing a colonoscopy.
Tetracyclines Penicillins may have a lower therapeutic efficacy.
Typhoid Vaccine The therapeutic effects of Typhoid vaccine may be diminished by antibiotics. The only affected strain is the live attenuated Ty21a. Patients being treated with systemic antibiotics should avoid vaccination with live attenuated Typhoid vaccine (Ty21a). This vaccine should not be used until at least three days after the cessation or discontinuance of antibacterial agents.

Risk Factor X (Avoid Combination)

 
BCG (Intravesical). The therapeutic effects of BCG (Intravesical) may be diminished by antibiotics
Cholera Vaccine Cholera Vaccine may be less effective if taken with antibiotics. Treatment: Cholera vaccine should be avoided in patients who have received systemic antibiotics.

Monitoring parameters:

  • With prolonged Amoxicillin therapy, renal, hepatic, and hematologic functions should be monitored periodically.
  • Clinical features of anaphylaxis should be observed after the administration of the first amoxicillin dose. The patient should be evaluated periodically for the response to therapy. 

Amoxicillin dose administration in adults:

  • The drug should be administered around-the-clock to avoid variations in the plasma levels.
  • The extended-release formulation should be administered within one hour of finishing a meal. The tablets and capsules should not be crushed or chewed.
  • The oral suspension should be shaken well before use. It may be mixed with formula, milk, fruit juice, water, ginger ale, or cold drinks.

Amoxicillin dose administration in children:

  • Amoxicillin may be administered on an empty or full stomach. It may be mixed with formula, milk, cold drink, or juice.
  • The suspension should be shaken well before use and the dose should be administered after mixing.
  • The extended-release formulation should be administered within one hour of a meal.
  • The tablets and capsules should be swallowed whole. Crushing or chewing the tablets should be avoided.

Mechanism of action of Amoxicillin:

  • It inhibits the cell wall synthesis by binding to penicillin-binding protein (PBPs), which in turn inhibits peptidoglycan production in bacterial cell walls. 
  • This causes the death of the bacteria.

AbsorptionThe oral immediate-release formulation is faster than the extended-release. The absorption rate is affected by food.

It isdistributedIt can be absorbed easily and quickly into the liver, lungs and prostate, muscle, middle-ear effusions and maxillary sinus secretions, bone and gallbladder, as well as into synovial and ascitic fluids.

CSF penetrationExcept in patients with inflamed spleens, it is not poor.

Half-life eliminationThe time required to prepare the immediate-release or extended-release formulations can vary from one hour up to 90 minutes.

Time until plasma concentration peaksDepending on the formulation, it can take anywhere from one to three hours.

Excretion is mainly via Urine (60% as unchanged drug.

International brands of amoxicillin:

  • A.M. Mox
  • Abiolex
  • Acilina
  • Acimox
  • Adbiotin
  • Alemox
  • Alfamox
  • Almorsan
  • Alphamox
  • Amicil
  • Amimox
  • Amitron
  • Amixen
  • Ammimox
  • Amobay
  • Amobiotic
  • Amoclan
  • Amodex
  • Amolin
  • Amorion
  • Amosin
  • Amotaks
  • Amoval
  • Amox
  • Amoxal
  • Amoxapen
  • Amoxar
  • Amoxcillin
  • Amoxen
  • Amoxibay
  • Amoxibel
  • Amoxibeta
  • Amoxicap
  • Amoxicid
  • Amoxicilina
  • Amoxiclin
  • Amoxidal
  • Amoxidin
  • Amoxidin 7
  • Amoxifur
  • Amoxiga
  • Amoxigran
  • Amoxil
  • Amoxilan
  • Amoxilin
  • Amoxin
  • Amoxipen
  • Amoxipenil
  • Amoxisol
  • Amoxistad
  • Amoxitab
  • Amoxivan
  • Amoxivet
  • Amoxsan
  • Amoxy
  • Amoxy Care Forte
  • Amoxydar
  • Ampin
  • Amyn
  • Anamox
  • Apimox
  • Aproxal
  • Aroxin
  • Atak
  • Atoksilin
  • Avlomox
  • Bactox
  • Bactox Ge
  • Beamoxy
  • Berlimox
  • Betamox
  • Betmox
  • Brumox
  • Bufamoxy
  • Cipamox
  • Clamoxyl
  • Clonamox
  • Coamox
  • Devamox
  • Dimopen
  • Duomox
  • Duzimicin
  • Dymoxin
  • E-Mox
  • Ecobol
  • Edamox
  • Elmox
  • Ethimox
  • Fabamox
  • Flemoxin
  • Foxolin
  • Geramox
  • Gexcil
  • Glomox
  • Gramox
  • Grinsul
  • Grunamox
  • Hiconcil
  • Hikoncil
  • Hymox
  • Hypher
  • Ibiamox
  • Ikamoxyl
  • Imadrax
  • Imox
  • InfectoMox
  • J Mox
  • Julphamox
  • Jutamox
  • Kemox
  • Kymoxin
  • Lamoxy
  • Largopen
  • Linmox
  • Magnimox
  • Manmox
  • Max
  • Maxamox
  • Medomox
  • Meixil
  • Miloxy
  • Mopen
  • Morgenxil
  • Mox
  • Moxatid
  • Moxi
  • Moxicor
  • Moxifar
  • Moxilen
  • Moxilin
  • Moxiram
  • Moxol
  • Moxtam
  • Moxxo
  • Moxylin
  • Moxypen
  • Moxyvit
  • Mymox
  • Neomox
  • Nobactam
  • Novamox
  • Novamoxin
  • Novax
  • Numoxylin
  • Ocylin
  • Opimox
  • Opimox Forte
  • Optamox
  • Oramox
  • Ospamox
  • Pamocil
  • Pamoxin
  • Pasetocin
  • Penamox
  • Penbiosyn
  • Pinamox
  • Pyramox
  • Ranmoxy
  • Ranoxyl
  • Remox
  • Remoxil
  • Ri Ao
  • Rivamox
  • Sanet
  • Sapox
  • Sawacillin
  • Sia-mox
  • Sinot
  • Solpenox
  • Strimox
  • Taimox
  • Telmox
  • Teramoxyl
  • Trifamox
  • Trimoxal
  • Ultramox
  • Unimox
  • Velamox
  • Widecillin
  • Winpen
  • Yomax
  • Zai Lin
  • Zeemox
  • Zerrsox
  • Zimox
  • Zymoxyl
  • AG-Amoxicillin
  • Amox 250
  • Amox 500
  • Amox S 125
  • Amox S 250
  • APO-Amoxi
  • APO-Amoxi Sugar Free
  • Auro-Amoxicillin
  • DOM-Amoxicillin
  • JAMP-Amoxicillin
  • Moxilean 50
  • MYLAN-Amoxicillin
  • Novamoxin
  • NTP-Amoxicillin
  • PHL-Amoxicillin
  • PMS-Amoxicillin
  • Polymox
  • PRO Amox-500
  • PRO-Amox-250

Amoxicillin Brands in Pakistan:

Amoxicillin 1 gm injection

MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
SUPRAMOX BOSCH PHARMACEUTICALS (PVT) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

 

       Amoxicillin Suspension 250 mg/5ml

ADAMOX ADAMJEE PHARMACEUTICALS (PVT) LTD.
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOLEXIN LEXICON PHARMACEUTICALS (PVT) LTD.
AMOXASCOT SCOTMANN PHARMACEUTICALS
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXICILLIN MEDIMARKERS PHARMACEUTICALS
AMOXICILLIN SWISS PHARMACEUTICALS (PVT) LTD.
AMOXIDOX STAR LABORATORIES (PVT) LTD.
AMOXIGEN PHARMAAGEN LTD.
AMOXIL GLAXOSMITHKLINE
AMOXIL GLAXOSMITHKLINE
AMOXILITE ELITE PHARMA
AMOXIMED MEDIATE PHARMACEUTICALS (PVT) LTD
AMOXYGEN GENERA PHARMACEUTICALS
ARCOMOX PAKISTAN PHARMACEUTICAL PRODUCTS (PVT) LTD.
BLOMOX FORTE BLOOM PHARMACEUTICALS (PVT) LTD.
CIPAMOX FORTE EPLA LABORATORIES (PVT) LTD.
CLOCIL FORTE MUNAWAR PHARMA (PVT) LTD.
CONCIMOX CONVELL LABORATORIES
COSMOX HARMANN PHARMACEUTICAL LABORATORIES (PVT) LTD.
DELMOX DELTA PHARMA (PVT) LTD.
EFFIMOX WILSONS PHARMACEUTICALS
ELMOX ELKO ORGANIZATION (PVT) LTD.
ENMOX ENGLISH PHARMACEUTICALS INDUSTRIES
EXCELLIN DR. RAZA PHARMA (PRIVATE) LIMITED
FEDRAXIL FEDRO PHARMACEUTICAL
GEOMOXIN GEOFMAN PHARMACEUTICALS
GLOXIL GLOBAL PHARMACEUTICALS
HIZEMOX HIZAT PHARMACEUTICAL INDUSTRIES (PVT) LTD.
IMCOMOX IMCO PHARMACEUTICALS LABORATORIES
KLOX KARACHI CHEMICAL INDUSTRIES
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
MAXIL FORTE MACTER INTERNATIONAL (PVT) LTD.
MEDIMOX MEDICRAFT PHARMACEUTICALS (PVT) LTD.
MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXILIUM POPULAR CHEMICAL WORKS (PVT) LTD.
NAMOXIL NAWAN LABORATORIES (PVT) LTD.
NOVOMOX KRKA-PAK PHARMACEUTICAL & CHEMICAL WORKS
OSPAMOX NOVARTIS PHARMA (PAK) LTD
OSPAMOX NOVARTIS PHARMA (PAK) LTD
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
POLYXIL FORTE POLYFINE CHEMPHARMA (PVT) LTD.
PRINCIMOX GLAXOSMITHKLINE
PRINCIMOX GLAXOSMITHKLINE
SEMOCILLIN FORTE SEMOS PHARMACEUTICALS (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
SUPRAMOX BOSCH PHARMACEUTICALS (PVT) LTD.
SYNTICILLIN SYNTEX PHARMACEUTICALS
WERIMOX WERRICK PHARMACEUTICALS
WILMOX FORTE WILSHIRE LABORATORIES (PVT) LTD.
WISEP REMINGTON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
WYMOX PFIZER LABORATORIES LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.
ZEEMOX FORTE SEARLE PAKISTAN (PVT.) LTD.
ZEEMOX FORTE SEARLE PAKISTAN (PVT.) LTD.
ZEKATAC ZEPHYR PHARMATEC (PVT) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

 

         Amoxicillin 500 mg injection

AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOXIL GlaxoSmithKline
AMOXIL GlaxoSmithKline
AMOXYCILLIN HAJI MEDICINE CO.
GLOXIL GLOBAL PHARMACEUTICALS
KLOX KARACHI CHEMICAL INDUSTRIES
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
NAMOXIL NAWAN LABORATORIES (PVT) LTD.
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
SUPRAMOX BOSCH PHARMACEUTICALS (PVT) LTD.
WYMOX PFIZER LABORATORIES LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

 

  Amoxicillin Drops 125 mg/1.25ml
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOXASCOT SCOTMANN PHARMACEUTICALS
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXIL GLAXOSMITHKLINE
AMOXIL GLAXOSMITHKLINE
CONCIMOX CONVELL LABORATORIES
FEDRAXIL FEDRO PHARMACEUTICAL
JAXCIL IRZA PHARMA (PVT) LTD.
KLOX KARACHI CHEMICAL INDUSTRIES
MAXIL MACTER INTERNATIONAL (PVT) LTD.
MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXILIUM POPULAR CHEMICAL WORKS (PVT) LTD.
MOXIN ANKAZ PHARMEX (PVT) LTD.
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

 

Amoxicillin Drops 125 mg/1.25ml

AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOXASCOT SCOTMANN PHARMACEUTICALS
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXIL GLAXOSMITHKLINE
AMOXIL GLAXOSMITHKLINE
CONCIMOX CONVELL LABORATORIES
FEDRAXIL FEDRO PHARMACEUTICAL
JAXCIL IRZA PHARMA (PVT) LTD.
KLOX KARACHI CHEMICAL INDUSTRIES
MAXIL MACTER INTERNATIONAL (PVT) LTD.
MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXILIUM POPULAR CHEMICAL WORKS (PVT) LTD.
MOXIN ANKAZ PHARMEX (PVT) LTD.
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

 

   Amoxicillin Susp 250 mg/5ml
ADAMOX ADAMJEE PHARMACEUTICALS (PVT) LTD.
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOLEXIN LEXICON PHARMACEUTICALS (PVT) LTD.
AMOXASCOT SCOTMANN PHARMACEUTICALS
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXICILLIN MEDIMARKERS PHARMACEUTICALS
AMOXICILLIN SWISS PHARMACEUTICALS (PVT) LTD.
AMOXIDOX STAR LABORATORIES (PVT) LTD.
AMOXIGEN PHARMAAGEN LTD.
AMOXIL GLAXOSMITHKLINE
AMOXIL GLAXOSMITHKLINE
AMOXILITE ELITE PHARMA
AMOXIMED MEDIATE PHARMACEUTICALS (PVT) LTD
AMOXYGEN GENERA PHARMACEUTICALS
ARCOMOX PAKISTAN PHARMACEUTICAL PRODUCTS (PVT) LTD.
BLOMOX FORTE BLOOM PHARMACEUTICALS (PVT) LTD.
CIPAMOX FORTE EPLA LABORATORIES (PVT) LTD.
CLOCIL FORTE MUNAWAR PHARMA (PVT) LTD.
CONCIMOX CONVELL LABORATORIES
COSMOX HARMANN PHARMACEUTICAL LABORATORIES (PVT) LTD.
DELMOX DELTA PHARMA (PVT) LTD.
EFFIMOX WILSONS PHARMACEUTICALS
ELMOX ELKO ORGANIZATION (PVT) LTD.
ENMOX ENGLISH PHARMACEUTICALS INDUSTRIES
EXCELLIN DR. RAZA PHARMA (PRIVATE) LIMITED
FEDRAXIL FEDRO PHARMACEUTICAL
GEOMOXIN GEOFMAN PHARMACEUTICALS
GLOXIL GLOBAL PHARMACEUTICALS
HIZEMOX HIZAT PHARMACEUTICAL INDUSTRIES (PVT) LTD.
IMCOMOX IMCO PHARMACEUTICALS LABORATORIES
KLOX KARACHI CHEMICAL INDUSTRIES
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
MAXIL FORTE MACTER INTERNATIONAL (PVT) LTD.
MEDIMOX MEDICRAFT PHARMACEUTICALS (PVT) LTD.
MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXILIUM POPULAR CHEMICAL WORKS (PVT) LTD.
NAMOXIL NAWAN LABORATORIES (PVT) LTD.
NOVOMOX KRKA-PAK PHARMACEUTICAL & CHEMICAL WORKS
OSPAMOX NOVARTIS PHARMA (PAK) LTD
OSPAMOX NOVARTIS PHARMA (PAK) LTD
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
POLYXIL FORTE POLYFINE CHEMPHARMA (PVT) LTD.
PRINCIMOX GLAXOSMITHKLINE
PRINCIMOX GLAXOSMITHKLINE
SEMOCILLIN FORTE SEMOS PHARMACEUTICALS (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
SUPRAMOX BOSCH PHARMACEUTICALS (PVT) LTD.
SYNTICILLIN SYNTEX PHARMACEUTICALS
WERIMOX WERRICK PHARMACEUTICALS
WILMOX FORTE WILSHIRE LABORATORIES (PVT) LTD.
WISEP REMINGTON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
WYMOX PFIZER LABORATORIES LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.
ZEEMOX FORTE SEARLE PAKISTAN (PVT.) LTD.
ZEEMOX FORTE SEARLE PAKISTAN (PVT.) LTD.
ZEKATAC ZEPHYR PHARMATEC (PVT) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

 

Amoxicillin Suspension 500 mg/5ml

AMOLEXIN LEXICON PHARMACEUTICALS (PVT) LTD.

 

 Amoxicillin Oral Solution 125 mg/1.25ml
AMOXIPEN PAEDIATRIC LISKO PAKISTAN (PVT) LTD
AMOXIPEN PAEDIATRIC LISKO PAKISTAN (PVT) LTD

 

         Amoxicillin Dry Suspension 125 mg/5ml

EPOXIL EPOCH PHARMACEUTICAL
GABOXIL GABA PHARMACEUTICALS LABS

 

   Amoxicillin Dry Suspension 250 mg/5ml

GABOXIL GABA PHARMACEUTICALS LABS

 

Amoxicillin 1000 mg Tablets
ENMOX ENGLISH PHARMACEUTICALS INDUSTRIES
OSPAMOX NOVARTIS PHARMA (PAK) LTD
WILMOX WILSHIRE LABORATORIES (PVT) LTD.
WISEP REMINGTON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.

 

Amoxicillin 200 mg Tablets

WILMOX CHEWABLE WILSHIRE LABORATORIES (PVT) LTD.

 

Amoxicillin 400 mg Tablets

WILMOX CHEWABLE WILSHIRE LABORATORIES (PVT) LTD.

 

Amoxicillin 500 mg Tablets

COSMOX HARMANN PHARMACEUTICAL LABORATORIES (PVT) LTD.
ENMOX ENGLISH PHARMACEUTICALS INDUSTRIES
MOXIN ANKAZ PHARMEX (PVT) LTD.
MOXIN ANKAZ PHARMEX (PVT) LTD.
OSPAMOX NOVARTIS PHARMA (PAK) LTD
OSPAMOX NOVARTIS PHARMA (PAK) LTD
WISEP REMINGTON PHARMACEUTICAL INDUSTRIES (PVT) LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.

 

Amoxicillin 125 mg Capsules

VAROFLOX MASS PHARMA (PRIVATE) LIMITED

 

Amoxicillin 250 mg Capsules

ADAMOX ADAMJEE PHARMACEUTICALS (PVT) LTD.
ALMOX ALSON PHARMACEUTICALS
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOLEXIN LEXICON PHARMACEUTICALS (PVT) LTD.
AMOX EURO PHARMA INTERNATIONAL
AMOX EURO PHARMA INTERNATIONAL
AMOXASCOT SCOTMANN PHARMACEUTICALS
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXICILLIN EURO PHARMA INTERNATIONAL
AMOXIDOX STAR LABORATORIES (PVT) LTD.
AMOXIGEN PHARMAAGEN LTD.
AMOXIL GLAXOSMITHKLINE
AMOXIL GLAXOSMITHKLINE
AMOXILITE ELITE PHARMA
AMOXILITE ELITE PHARMA
AMOXIMED MEDIATE PHARMACEUTICALS (PVT) LTD
AMOXIPEN LISKO PAKISTAN (PVT) LTD
AMOXYGEN GENERA PHARMACEUTICALS
AMOXYGEN GENERA PHARMACEUTICALS
ARCOMOX PAKISTAN PHARMACEUTICAL PRODUCTS (PVT) LTD.
AXALYN UNEXO LABS (PVT) LTD.
AXALYN UNEXO LABS (PVT) LTD.
AXALYN UNEXO LABS (PVT) LTD.
CIPAMOX EPLA LABORATORIES (PVT) LTD.
CIPAMOX EPLA LABORATORIES (PVT) LTD.
CLIMOX MARVI LABORATORIES
CONCIMOX CONVELL LABORATORIES
DELMOX DELTA PHARMA (PVT) LTD.
EFFIMOX WILSONS PHARMACEUTICALS
EPOXIL EPOCH PHARMACEUTICAL
EPOXIL EPOCH PHARMACEUTICAL
ETHICILLIN ETHICAL LABORATORIES (PVT) LTD.
EXCELLIN DR. RAZA PHARMA (PRIVATE) LIMITED
FEDRAXIL FEDRO PHARMACEUTICAL
FEDRAXIL FEDRO PHARMACEUTICAL
FEDRAXIL FEDRO PHARMACEUTICAL
FEDRAXIL FEDRO PHARMACEUTICAL
GABOXIL GABA PHARMACEUTICALS LABS
GEOMOXIN GEOFMAN PHARMACEUTICALS
GEOMOXIN GEOFMAN PHARMACEUTICALS
GLOXIL GLOBAL PHARMACEUTICALS
JAXCIL IRZA PHARMA (PVT) LTD.
JAXCIL IRZA PHARMA (PVT) LTD.
KEMYCLOX ALKEMY PHARMACEUTICAL LABORATORIES (PRIVATE) LTD.
KLOX KARACHI CHEMICAL INDUSTRIES
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
MAXIL MACTER INTERNATIONAL (PVT) LTD.
MB-MOX MULTINATIONAL BUISNESS LINK
MEDIMOX MEDICRAFT PHARMACEUTICALS (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXILIUM POPULAR CHEMICAL WORKS (PVT) LTD.
NAMOXIL NAWAN LABORATORIES (PVT) LTD.
NOVOMOX KRKA-PAK PHARMACEUTICAL & CHEMICAL WORKS
NOVOMOX KRKA-PAK PHARMACEUTICAL & CHEMICAL WORKS
OCEMOX SAFE PHARMACEUTICAL (PVT) LTD.
OSPAMOX NOVARTIS PHARMA (PAK) LTD
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
POLYXIL POLYFINE CHEMPHARMA (PVT) LTD.
PRINCIMOX GLAXOSMITHKLINE
PRINCIMOX GLAXOSMITHKLINE
SEMOCILLIN SEMOS PHARMACEUTICALS (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
SUPRAMOX BOSCH PHARMACEUTICALS (PVT) LTD.
SYNTICILLIN SYNTEX PHARMACEUTICALS
WERIMOX WERRICK PHARMACEUTICALS
WILMOX WILSHIRE LABORATORIES (PVT) LTD.
WILMOX WILSHIRE LABORATORIES (PVT) LTD.
WYMOX PFIZER LABORATORIES LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.
ZEKATAC ZEPHYR PHARMATEC (PVT) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.

Amoxicillin 500 mg capsules

ABAC RAKAPOSHI PHARMACEUTICAL (PVT) LTD.
ADAMOX ADAMJEE PHARMACEUTICALS (PVT) LTD.
ALMOX ALSON PHARMACEUTICALS
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOCILLIN CONSOLIDATED CHEMICAL LABORATORIES (PVT) LTD.
AMOLEXIN LEXICON PHARMACEUTICALS (PVT) LTD.
AMOX EURO PHARMA INTERNATIONAL
AMOX EURO PHARMA INTERNATIONAL
AMOXASCOT SCOTMANN PHARMACEUTICALS
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXICAP DON VALLEY PHARMACEUTICALS (PVT) LTD.
AMOXICILLIN EURO PHARMA INTERNATIONAL
AMOXICILLIN EURO PHARMA INTERNATIONAL
AMOXICILLIN AMROS PHARMACEUTICALS.
AMOXIDOX STAR LABORATORIES (PVT) LTD.
AMOXIGEN PHARMAAGEN LTD.
AMOXIL GLAXOSMITHKLINE
AMOXIL GLAXOSMITHKLINE
AMOXILITE ELITE PHARMA
AMOXILITE ELITE PHARMA
AMOXILLIN IDEAL PHARMACEUTICAL INDUSTRIES
AMOXILLIN IDEAL PHARMACEUTICAL INDUSTRIES
AMOXIMED MEDIATE PHARMACEUTICALS (PVT) LTD
AMOXIPEN LISKO PAKISTAN (PVT) LTD
AMOXYGEN GENERA PHARMACEUTICALS
AMOXYGEN GENERA PHARMACEUTICALS
ARCOMOX PAKISTAN PHARMACEUTICAL PRODUCTS (PVT) LTD.
AXALYN UNEXO LABS (PVT) LTD.
AXALYN UNEXO LABS (PVT) LTD.
BLOMOX BLOOM PHARMACEUTICALS (PVT) LTD.
CIPAMOX EPLA LABORATORIES (PVT) LTD.
CIPAMOX EPLA LABORATORIES (PVT) LTD.
CLIMOX MARVI LABORATORIES
CONCIMOX CONVELL LABORATORIES
DELMOX DELTA PHARMA (PVT) LTD.
EFFIMOX WILSONS PHARMACEUTICALS
EPOXIL EPOCH PHARMACEUTICAL
EPOXIL EPOCH PHARMACEUTICAL
ETHICILLIN ETHICAL LABORATORIES (PVT) LTD.
ETHICILLIN ETHICAL LABORATORIES (PVT) LTD.
EXCELLIN DR. RAZA PHARMA (PRIVATE) LIMITED
FEDRAXIL FEDRO PHARMACEUTICAL
FEDRAXIL FEDRO PHARMACEUTICAL
FEDRAXIL FEDRO PHARMACEUTICAL
GABOXIL GABA PHARMACEUTICALS LABS
GEOMOXIN GEOFMAN PHARMACEUTICALS
GLOXIL GLOBAL PHARMACEUTICALS
GLOXIL GLOBAL PHARMACEUTICALS
HIZEMOX HIZAT PHARMACEUTICAL INDUSTRIES (PVT) LTD.
IMCOMOX IMCO PHARMACEUTICALS LABORATORIES
JAXCIL IRZA PHARMA (PVT) LTD.
JAXCIL IRZA PHARMA (PVT) LTD.
KEMYCLOX ALKEMY PHARMACEUTICAL LABORATORIES (PRIVATE) LTD.
KLOX KARACHI CHEMICAL INDUSTRIES
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
LOMOXY LOWITT PHARMACEUTICALS (PVT) LTD
MAXIL MACTER INTERNATIONAL (PVT) LTD.
MB-MOX MULTINATIONAL BUISNESS LINK
MEDIMOX MEDICRAFT PHARMACEUTICALS (PVT) LTD.
MEDIOXIL MEDICEENA PHARMA (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXIFIL FERROZA INTERNATIONAL PHARMACEUTICALS (PVT) LTD.
MOXILIUM POPULAR CHEMICAL WORKS (PVT) LTD.
NAMOXIL NAWAN LABORATORIES (PVT) LTD.
NOVOMOX KRKA-PAK PHARMACEUTICAL & CHEMICAL WORKS
NOVOMOX KRKA-PAK PHARMACEUTICAL & CHEMICAL WORKS
OCEMOX SAFE PHARMACEUTICAL (PVT) LTD.
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PEMOXIN KARACHI PHARMACEUTICAL LABORATORY
PENBRO P.D.H. PHARMACEUTICALS (PVT) LTD.
POLYXIL POLYFINE CHEMPHARMA (PVT) LTD.
PRINCIMOX GLAXOSMITHKLINE
PRINCIMOX GLAXOSMITHKLINE
SEMOCILLIN SEMOS PHARMACEUTICALS (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
SKYMOX HAMAZ PHARMACEUTICAL (PVT) LTD.
SUPRAMOX BOSCH PHARMACEUTICALS (PVT) LTD.
SYNTICILLIN SYNTEX PHARMACEUTICALS
WERIMOX WERRICK PHARMACEUTICALS
WILMOX WILSHIRE LABORATORIES (PVT) LTD.
WILMOX WILSHIRE LABORATORIES (PVT) LTD.
WYMOX PFIZER LABORATORIES LTD.
ZEEMOX SEARLE PAKISTAN (PVT.) LTD.
ZEKATAC ZEPHYR PHARMATEC (PVT) LTD.
ZOXICILLIN ZAFA PHARMACEUTICAL LABORATORIES (PVT) LTD.