A first-generation antihistamine called brompheniramine is used to treat allergic rhinitis, urticaria, the common cold,  and the flu.  It is used to treat hay fever, allergic rhinitis, and other upper respiratory allergiesrelated itchy, watery, and runny eyes, nose,  and throat symptoms temporarily.

Brompheniramine Dose in Adults

For the symptoms of Cold and flu, allergic rhinitis, and urticaria:

• Immediate release:
  • 4 - 8 mg every 4 to 8 hours
• Extended-release:
  • 6 - 12 mg every twelve hourly to a maximum dose of 24 mg per day.

Brompheniramine Dose in Childrens

Dose in the treatment of rhinitis and upper respiratory allergies:

• Children 2 - 6 years of age:
  • 1 mg (1 mL) orally every 4 - 6 hours to a maximum dose of 6 mg [6 mL] per day.
• Children 6 - 12 years of age:
  • 2 mg (2 mL) orally every 4 - 6 hours to a maximum dose of 12 mg [12 mL] per day.

Pregnancy Risk Factor: C

• Although data is not available, it is known that there is a low risk of birth defects in patients who are on first-generation antihistamines.
• It can be used to treat rhinitis and urticaria in pregnant women.
• Patients with intrahepatic-cholestasis are not advised to use antihistamines for itching or pruritis.

Brompheniramine use during breastfeeding:

• Its use during breastfeeding is not well documented.
• Second-generation antihistamines are preferred because of the potential adverse effects in neonates.
• It is important to monitor children for irritability or drowsiness.
• It can also lower serum prolactin levels, and impair lactation.

Brompheniramine Dose in Renal Disease:

• In patients with renal impairment, dose modification is not necessary.

Brompheniramine Dose in Liver Disease:

•  It should be used with caution in patients with advanced liver disease and hepatic encephalopathy. 

 Side effects of brompheniramine (Frequency not defined):

• Cardiovascular:
  • Angina Pectoris
  • Chest Tightness
  • Circulatory Shock
  • Extrasystoles
  • Hypotension
  • Increased Blood Pressure
  • Palpitations
  • Tachycardia
• Central Nervous System:
  • Anxiety
  • Ataxia
  • Central Nervous System Stimulation
  • Chills
  • Confusion
  • Dizziness
  • Drowsiness
  • Euphoria
  • Excitement
  • Fatigue
  • Headache
  • Hysteria
  • Insomnia
  • Irritability
  • Nervousness
  • Neuritis
  • Paresthesia
  • Restlessness
  • Sedation
  • Seizure
  • Tension
  • Vertigo
• Dermatologic:
  • Diaphoresis
  • Skin Photosensitivity
  • Skin Rash
  • Urticaria
• Gastrointestinal:
  • Abdominal Cramps
  • Anorexia
  • Constipation
  • Diarrhea
  • Epigastric Distress
  • Heartburn
  • Nausea
  • Vomiting
  • Xerostomia
• Genitourinary:
  • Dysuria
  • Early Menses
  • Urinary Retention
• Hematologic & Oncologic:
  • Agranulocytosis
  • Hemolytic Anemia
  • Hypoplastic Anemia
  • Thrombocytopenia
• Hypersensitivity:
  • Anaphylactic Shock
• Neuromuscular & Skeletal:
  • Tremor
  • Weakness
• Ophthalmic:
  • Blurred Vision
  • Diplopia
  • Mydriasis
• Otic:
  • Acute Labyrinthitis
  • Tinnitus
• Renal:
  • Polyuria
• Respiratory:
  • Dry Nose
  • Dry Throat
  • Nasal Congestion
  • Thickening Of Bronchial Secretions
  • Wheezing

Contraindication to Brompheniramine Include:

• Contraindications are not listed on the label.

Warnings and Precautions

• CNS depression:
  • It can cause CNS depression, which may lead to impairment of mental or physical abilities.
  • Patients who perform tasks that require mental alertness, such as drivers or heavy-duty workers, should be advised to take the drug with caution.
• Cardiovascular disease
  • Patients with hypertension or ischemic heart disease should be cautious about taking the drug.
• Increased intraocular pressure
  • Glaucoma patients and those with high intraocular pressure need to be cautious.
• Prostatic hyperplasia, urinary obstruction
  • Patients with prostatic hyperplasia and genitourinary retention should be cautious about using the drug.
• Respiratory problems
  • Patients who have asthma or chronic bronchitis should not use this drug.
• Thyroid dysfunction:
  • Thyroid disease patients should be cautious when using the drug.

Brompheniramine: Drug Interaction

Note: Drug Interaction Categories:

• Risk Factor C: Monitor When Using Combination
• Risk Factor D: Consider Treatment Modification
• Risk Factor X: Avoid Concomitant Use

How to take Brompheniramine?

• Administer the oral solution via the dropper provided by the manufacturer.

Mechanism of action of Brompheniramine:

It inhibits competitively the Histamine (H-1) receptors on effector cells.

39-49 percent of the drug isprotein-boundIt is. It isMetabolizedThe liver is responsible for generating the aforementioned.half-life eliminationChildren spend 12 hours on average and adults spend 25 hours.

TheTime to achieve peak serum concentrationIt takes 3 to 3.5 hours for children and 2-4 hours for adults. 

It is primarilyexcretedIn the urine. 

International brands of Brompheniramine:

• J-Tan PD
• Respa-BR
• Bomine
• Bromine
• Bromma
• Bromphen
• Broramin
• Dimetane
• Probrom

Brompheniramine Brands in Pakistan:

 No brands available in Pakistan