Cetylpyridinium chloride is an antiseptic that kills bacteria and fungi in the oral cavity with repeated use as a mouthwash and is used in the prevention and reduction of plaque and gingivitis. It is also a component of toothpastes, lozenges, nasal & oral sprays, and is used to freshen the breath.

Cetylpyridinium chloride Dose in Adults

• Use as Antiseptic

  • Swish 20 mL thoroughly between the teeth for 30 seconds and then spit it out.
  • Use two times a day.
  • It can be used before or after brushing
  • It should not be ingested.

Cetylpyridinium chloride Dose in Childrens

• Use as Antiseptic in children older than 6 years of age:

  • Swish 20 mL thoroughly between the teeth for 30 seconds and then spit it out.
  • Use two times a day.
  • It can be used before or after brushing
  • It should not be ingested.

Pregnancy Risk Factor B

• It is safe for use on the skin and does not cause harm to the fetus.
•  Regular use as a mouthwash has been associated with a reduction in preterm births in pregnant females with gingivitis and periodontal disease.

Use during breastfeeding:

• It can be used as a topical agent, so it can also be used while you breastfeed.

Cetylpyridinium chloride Dose in Renal Disease:

• No dose adjustment is required in Renal diseases.

Cetylpyridinium chloride Dose in Liver Disease:

• No dose adjustment is required in Liver diseases.

Common Side Effects Of Cetylpyridinium chloride include:

• Gastrointestinal:
  • Dental discoloration
  • Mouth irritation
  • Tongue discoloration

Contraindication to Cetylpyridinium chloride include:

• Allergy reactions to cetylpyridinium chlorineide or any other component of the formulation

Warnings and Precautions

• Accidental ingestion:
  • If swallowed in large quantities, professional advice is recommended. It is estimated that the toxic dose ranges from 1 to 3 grams.
• Self-medication (OTC):
  • If you notice any of these signs, it is best to not use it.
    • If symptoms or conditions persist despite treatment.
    • Gingivitis is characterized by reddening or bleeding that persists for longer than two weeks.
    • If your gums become swollen or painful
    • Pus from the gum line can cause pus to ooze, which causes the teeth to loosen or the spacing between them to occur.
• Avoid contact with the eyes.

Monitoring Parameters:

Monitor the teeth for staining if used for a longer duration.

How to administer Cetylpyridinium chloride?

It should be vigorously swished between teeth after an oral rinse and should nnot be  swallowed.

Mechanism of action of Cetylpyridinium chloride:

• It is an aQuaternary ammoniumm compoundsUseful in mouth washes and lozenges, toothpasts and oral and nasal sprays.
• It can be used OTC to treat gingivitis or for the removal plaques. It is antiseptic and can kill bacteria and fungi by repeated use.

International brands of Cetylpyridinium chloride:

• Algol
• Alsol
• Angifonil
• B-Fresh
• Bat Zeta
• Borocaina
• Bronchenolo Gola
• Cetilsan
• Cetosept
• Cleanthroat
• Coolstrip Film
• Troche
• Curisol
• Dobendan
• Farin Gola
• Geyderm Sepsi
• Golacetin
• Herbagola
• Menthosept
• Merocet
• Merocets
• Neo Cepacol
• Neo Coricidin
• Neo Formitrol
• Novoptine
• Pronto G
• Pyrisept
• Tirocetil

Cetylpyridinium Chloride brands in Pakistan: