Cetylpyridinium chloride - an Antiseptic for Gingivitis

Cetylpyridinium chloride is an antiseptic that kills bacteria and fungi in the oral cavity with repeated use as a mouthwash and is used in the prevention and reduction of plaque and gingivitis. It is also a component of toothpastes, lozenges, nasal & oral sprays, and is used to freshen the breath.

 

Cetylpyridinium chloride Dose in Adults

  • Use as Antiseptic

    • Swish 20 mL thoroughly between the teeth for 30 seconds and then spit it out.
    • Use two times a day.
    • It can be used before or after brushing
    • It should not be ingested.

Cetylpyridinium chloride Dose in Childrens

  • Use as Antiseptic in children older than 6 years of age:

    • Swish 20 mL thoroughly between the teeth for 30 seconds and then spit it out.
    • Use two times a day.
    • It can be used before or after brushing
    • It should not be ingested.

Pregnancy Risk Factor B

  • It is safe for use on the skin and does not cause harm to the fetus.
  •  Regular use as a mouthwash has been associated with a reduction in preterm births in pregnant females with gingivitis and periodontal disease.

Use during breastfeeding:

  • It can be used as a topical agent, so it can also be used while you breastfeed.

Cetylpyridinium chloride Dose in Renal Disease:

  • No dose adjustment is required in Renal diseases.

Cetylpyridinium chloride Dose in Liver Disease:

  • No dose adjustment is required in Liver diseases.

Common Side Effects Of Cetylpyridinium chloride include:

  • Gastrointestinal:
    • Dental discoloration
    • Mouth irritation
    • Tongue discoloration

Contraindication to Cetylpyridinium chloride include:

  • Allergy reactions to cetylpyridinium chlorineide or any other component of the formulation

Warnings and Precautions

  • Accidental ingestion:
    • If swallowed in large quantities, professional advice is recommended. It is estimated that the toxic dose ranges from 1 to 3 grams.
  • Self-medication (OTC):
    • If you notice any of these signs, it is best to not use it.
      • If symptoms or conditions persist despite treatment.
      • Gingivitis is characterized by reddening or bleeding that persists for longer than two weeks.
      • If your gums become swollen or painful
      • Pus from the gum line can cause pus to ooze, which causes the teeth to loosen or the spacing between them to occur.
  • Avoid contact with the eyes.

 

Monitoring Parameters:

Monitor the teeth for staining if used for a longer duration.

How to administer Cetylpyridinium chloride?

It should be vigorously swished between teeth after an oral rinse and should nnot be  swallowed.

Mechanism of action of Cetylpyridinium chloride:

  • It is an aQuaternary ammoniumm compoundsUseful in mouth washes and lozenges, toothpasts and oral and nasal sprays.
  • It can be used OTC to treat gingivitis or for the removal plaques. It is antiseptic and can kill bacteria and fungi by repeated use.

International brands of Cetylpyridinium chloride:

  • Algol
  • Alsol
  • Angifonil
  • B-Fresh
  • Bat Zeta
  • Borocaina
  • Bronchenolo Gola
  • Cetilsan
  • Cetosept
  • Cleanthroat
  • Coolstrip Film
  • Troche
  • Curisol
  • Dobendan
  • Farin Gola
  • Geyderm Sepsi
  • Golacetin
  • Herbagola
  • Menthosept
  • Merocet
  • Merocets
  • Neo Cepacol
  • Neo Coricidin
  • Neo Formitrol
  • Novoptine
  • Pronto G
  • Pyrisept
  • Tirocetil

Cetylpyridinium Chloride brands in Pakistan:

Cetylpyridinium Chloride [Mouth Wash 0.05 %W/V]

Benride Mouth Wash Platinum Pharmaceuticals (Pvt.) Ltd.
Benzirin C Angelini Pharmaceuticals (Pvt) Ltd
Citacol Zanctok Pharmaceuticals
Dentisept Hiranis Pharmaceuticals Pvt Ltd

Cetylpyridinium Chloride [Gel 0.1 %W/W]

Chlorbenz Platinum Pharmaceuticals (Pvt.) Ltd.
Enziclor Platinum Pharmaceuticals (Pvt.) Ltd.

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