Docosanol is available as OTC cream and lip balm for topical application by the brand name of Abreva among others. It is used to treat cold sores and blisters.

Docosanol (Abreva) Uses:

• Cold sore and fever blister:

  • It is indicated for the treatment of cold sores and fever blisters on the face or lips.

Docosanol (Abreva) Dose in Adults

Docosanol (Abreva) Dose in the treatment of Cold sore and fever blister:

• Five times each day, topically apply to the lips or affected area of the face.
• When a cold sore or fever blister first appears, start therapy right away, and keep going until the lesions are gone.
• Stop using it and consult a healthcare professional if the lesions are not cured in 10 days.

Use in Children:

Refer to adult dosing. 

Use in Pregnancy and lactation:

It can be used in pregnant and breastfeeding women as systemic absorption is unlikely following its topical application. 

Dose in Kidney disease:

The manufacturer has not recommended any adjustments in the dose in patients with kidney disease. 

Dose in Liver disease:

The manufacturer has not recommended any adjustments in the dose in patients with liver disease. 

Side effects of Docosanol (Abreva):

• Hypersensitivity:

  • Hypersensitivity reaction

Contraindications to Docosanol (Abreva):

OTC labeling

• If you are allergic to docosanol, or any other component of the formulation, it is best not to use it

Warnings and precautions

• Hypersensitivity

  • It can cause severe allergic reactions such as hives and swelling.
  • Seek expert medical attention immediately if you notice an allergic reaction.

Docosanol: Drug Interaction

Note: Drug Interaction Categories:

• Risk Factor C: Monitor When Using Combination
• Risk Factor D: Consider Treatment Modification
• Risk Factor X: Avoid Concomitant Use

Monitoring parameters:

Monitor the response to treatment. If no improvement is noted or worsening of the underlying condition is noted, consult a healthcare professional. 

How to administer Docosanol?

• It is intended for topical application over the face and lips.
• Application over an around the eyes and inside the mouth should be avoided.
• Before applying the cream/ lip balm, wash the hands and apply only to the affected areas.
• Rub the medicine gently. After applying it, wash the hands.

Mechanism of action of Docosanol (Abreva):

It stops the virus from entering the cells and prevents its replication. 

International Brands of Docosanol:

• Abreva
• Blistex Cold Sore Cream
• Docozan
• Erazaban
• ERAZABAN
• Healip
• Herpiclavir
• Lafrost
• Muxan
• Priora

Docosanol Brands Names in Pakistan:

No Brands Available in Pakistan.