Jublia (efinaconazole) is an antifungal drug that is used to treat fungal infections of the toe nails.

Jublia (efinaconazole) Uses:

• Onychomycosis:

  • It is indicated for the topical management of toenail onychomycosis brought on by:
    Rubrum Trichophyton
    Mentagrophytes of Trichophyton

Dose in Adults

Jublia (efinaconazole) Dose in the treatment of Onychomycosis:

• For 48 weeks, it is placed topically over the affected toenails once every day.

Use in children:

Not indicated

Pregnancy Risk Factor C

• SubQ administration of the drug led to adverse outcomes in fetal reproduction studies on animals.
• Topical application may result in minimal systemic absorption.

Efinaconazole use during breastfeeding:

• It is unknown if the drug will be excreted into breast milk.
• The manufacturer suggests that nursing mothers use it with caution, even though there may be some systemic absorption.

Jublia (efinaconazole) Dose in Kidney disease:

The manufacturer has not provided any recommendations regarding dose adjustment in patients with kidney disease.

Jublia (efinaconazole) Dose in Liver disease:

The manufacturer has not provided any recommendations regarding dose adjustments in patients with liver disease.

Side Effects of Jublia (efinaconazole):

• Dermatologic:

  • Ingrown nail

• Local:

  • Application site vesicles
  • Application site dermatitis
  • Application site pain

Contraindication to Efinaconazole Include:

There are no contraindications for its use, according to the manufacturer. Canadian labeling:

• People who are allergic to any of the components or drugs should not use them.

Warnings and precautions

• Local irritation

  • Local skin irritation, pain, or dermatitis may occur.
  • Patients should seek professional advice if they continue to experience skin reactions.

Monitoring parameters:

None is mentioned in the manufacturer's labeling. Monitor the response to treatment.

How to administer Jublia (efinaconazole)?

• It is applied as a topical 10% solution over the affected toenails.
• Before applying the solution, the toenails should be clean and dry.
• After taking a shower or washing the toenails, wait for at least ten minutes before applying the solution.
• Hold the bottle directly over the affected toenail after removing the bottle cap.
• Apply one drop over the affected toenail by squeezing the bottle. Two drops may be applied if the big toe is affected.
• Using the attached applicator brush, gently spread the solution completely and thoroughly around the toenail.
• Cover the nailbed, nail folds, hyponychium, and the undersurface of the toenail.
• After proper application, let it dry and wash hands with soap and water.
• While using the treatment, stay away from pedicures, cosmetic nail products, and nail polish.

Mechanism of action :

• It is an antifungal medication from the "azoles" class that kills fungi by preventing the enzyme lanosterol14alpha-demethylase from functioning.
• This enzyme is responsible for the biosynthesis ergosterol, which is a component of fungal cell membranes.

Half-life elimination:

• 29.9 hours.

International Brand Names of Efinaconazole:

• Jublia
• Clenafin
• Efinconzol-UCCMA

Efinaconazole Brand Names in Pakistan:

• No Brands Available in Pakistan.