Emedastine (Emadine) - Uses, Dose, Side effects, MOA, Brands

Emedastine is an antihistamine medication primarily used to relieve symptoms of allergic conjunctivitis, such as itching and redness in the eyes. It belongs to a class of drugs known as H1 receptor antagonists, which work by blocking the action of histamine, a substance in the body that causes allergic symptoms.

Emedastine is commonly available in the form of eye drops and is typically used as directed by a healthcare professional. It provides relief from symptoms associated with seasonal allergic conjunctivitis and perennial allergic conjunctivitis.

Emedastine (Emadine) is a second-generation antihistamine that is used for ophthalmic use to relieve symptoms of allergic conjunctivitis.

Emedastine (Emadine) Uses:

  • Allergic conjunctivitis:
    • It is used for the symptomatic relief of allergic conjunctivitis.

Emedastine (Emadine) Dose in Adults

Emedastine (Emadine) Dose for Allergic conjunctivitis:

  • For allergic conjunctivitis, emedastine is used as eye drops.
  • You put one drop into the affected eye up to four times a day.

Use in children:

Instill one drop in the affected eye up o four times a day.

Emedastine (Emadine) Pregnancy Risk Category: B

  • In animal studies on reproduction, no harmful effects have been seen with emedastine.
  • When emedastine is applied to the eyes, only a small amount is absorbed into the body.
  • So, using it during pregnancy isn't expected to expose the fetus to significant levels of the medication.

Use during breastfeeding:

  • It's uncertain whether emedastine passes into breast milk.
  • Due to this uncertainty, the manufacturer advises caution when using emedastine in nursing mothers.
  • If you're breastfeeding and considering using emedastine.

Emadine Dose in Kidney disease:

  • The manufacturer's labeling does not include any specific dosage adjustments for emedastine in individuals with renal impairment.
  • This is likely because emedastine is primarily used as eye drops, and systemic absorption after ocular administration is minimal.
  • Therefore, dosage adjustments are not typically necessary for people with kidney problems.

Emadine Dose in Liver disease:

  • The manufacturer's labeling for emedastine does not include specific dosage adjustments for individuals with hepatic impairment.
  • This is because emedastine is primarily administered as eye drops, resulting in minimal systemic absorption.
  • Consequently, dosage adjustments are typically not required for people with liver issues.

Frequency not always defined.

Common Side Effects of Emedastine (Emadine):

  • Central nervous system:
    • Headache

Less Common Side Effects of Emedastine (Emadine):

  • Neuromuscular & skeletal:
    • Weakness
  • Cardiovascular:
    • Hyperemia
  • Dermatologic:
    • Dermatitis
    • Pruritus
  • Central nervous system:
    • Abnormal dreams
  • Gastrointestinal:
    • Dysgeusia
  • Respiratory:
    • Rhinitis
    • Sinusitis
  • Ophthalmic:
    • Transient burning or stinging in the eyes
    • Xerophthalmia
    • Corneal staining
    • Keratitis
    • Blurred vision
    • Corneal infiltrates
    • Lacrimation

Contraindications to Emedastine (Emadine):

  • If someone has a known hypersensitivity or allergy to emedastine or any component of the formulation, they should avoid using the medication.
  • Allergic reactions could occur if the individual is exposed to emedastine or any of its ingredients.
  • If you suspect you may be allergic to emedastine or any component of the formulation.

Monitoring parameters:

Not mentioned. However, monitor the response to the treatment. In case of worsening symptoms, consult a physician.

How to administer Emedastine (Emadine)?

  • Topical Use Only: Emedastine is meant for use in the eyes only. It should not be injected into the body.
  • Clean Hands: Before using emedastine, wash your hands thoroughly to prevent any contamination.
  • Avoid Touching: To prevent contamination, do not let the dropper tip touch your eyelids or any other surfaces when putting drops in your eyes.
  • Remove Contact Lenses: Take out your contact lenses before using emedastine eye drops.
  • Wait Before Reinserting Lenses: Wait at least 10 minutes before putting your contact lenses back in after using emedastine eye drops.
  • Avoid Lenses with Red Eyes: If your eyes are red, it's best not to wear contact lenses until the redness goes away.

Mechanism of action of Emedastine (Emadine):

  • Emedastine is a medication that works by blocking specific histamine receptors in the eyes, helping to relieve symptoms of allergies.
  • It's meant to be used as eye drops only.
  • When using emedastine, make sure your hands are clean, and avoid touching the dropper tip to prevent contamination.
  • Take out your contact lenses before using the eye drops and wait at least 10 minutes before putting them back in.
  • If your eyes are red, it's best not to wear contact lenses until the redness clears up.

Absorption:

  • Ocular: Emedastine is absorbed very minimally when applied to the eyes.

Half-life Elimination:

  • Oral:
    • Plasma: The time it takes for half of the emedastine to be eliminated from the bloodstream after oral administration is approximately 3 to 4 hours.

International Brand Names of Emedastine:

  • Emadine
  • Daren
  • Emeromin
  • Remicut SR

Emedastine Brand Names in Pakistan:

Emedastine Eye Drops 0.05 %w/v

Emadine

Novartis Pharma (Pak) Ltd

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