Emedastine is an antihistamine medication primarily used to relieve symptoms of allergic conjunctivitis, such as itching and redness in the eyes. It belongs to a class of drugs known as H1 receptor antagonists, which work by blocking the action of histamine, a substance in the body that causes allergic symptoms.

Emedastine is commonly available in the form of eye drops and is typically used as directed by a healthcare professional. It provides relief from symptoms associated with seasonal allergic conjunctivitis and perennial allergic conjunctivitis.

Emedastine (Emadine) is a second-generation antihistamine that is used for ophthalmic use to relieve symptoms of allergic conjunctivitis.

Emedastine (Emadine) Uses:

• Allergic conjunctivitis:
  • It is used for the symptomatic relief of allergic conjunctivitis.

Emedastine (Emadine) Dose in Adults

Emedastine (Emadine) Dose for Allergic conjunctivitis:

• For allergic conjunctivitis, emedastine is used as eye drops.
• You put one drop into the affected eye up to four times a day.

Use in children:

Instill one drop in the affected eye up o four times a day.

Emedastine (Emadine) Pregnancy Risk Category: B

• In animal studies on reproduction, no harmful effects have been seen with emedastine.
• When emedastine is applied to the eyes, only a small amount is absorbed into the body.
• So, using it during pregnancy isn't expected to expose the fetus to significant levels of the medication.

Use during breastfeeding:

• It's uncertain whether emedastine passes into breast milk.
• Due to this uncertainty, the manufacturer advises caution when using emedastine in nursing mothers.
• If you're breastfeeding and considering using emedastine.

Emadine Dose in Kidney disease:

• The manufacturer's labeling does not include any specific dosage adjustments for emedastine in individuals with renal impairment.
• This is likely because emedastine is primarily used as eye drops, and systemic absorption after ocular administration is minimal.
• Therefore, dosage adjustments are not typically necessary for people with kidney problems.

Emadine Dose in Liver disease:

• The manufacturer's labeling for emedastine does not include specific dosage adjustments for individuals with hepatic impairment.
• This is because emedastine is primarily administered as eye drops, resulting in minimal systemic absorption.
• Consequently, dosage adjustments are typically not required for people with liver issues.

Frequency not always defined.

Common Side Effects of Emedastine (Emadine):

• Central nervous system:
  • Headache

Less Common Side Effects of Emedastine (Emadine):

• Neuromuscular & skeletal:
  • Weakness
• Cardiovascular:
  • Hyperemia
• Dermatologic:
  • Dermatitis
  • Pruritus
• Central nervous system:
  • Abnormal dreams
• Gastrointestinal:
  • Dysgeusia
• Respiratory:
  • Rhinitis
  • Sinusitis
• Ophthalmic:
  • Transient burning or stinging in the eyes
  • Xerophthalmia
  • Corneal staining
  • Keratitis
  • Blurred vision
  • Corneal infiltrates
  • Lacrimation

Contraindications to Emedastine (Emadine):

• If someone has a known hypersensitivity or allergy to emedastine or any component of the formulation, they should avoid using the medication.
• Allergic reactions could occur if the individual is exposed to emedastine or any of its ingredients.
• If you suspect you may be allergic to emedastine or any component of the formulation.

Monitoring parameters:

Not mentioned. However, monitor the response to the treatment. In case of worsening symptoms, consult a physician.

How to administer Emedastine (Emadine)?

• Topical Use Only: Emedastine is meant for use in the eyes only. It should not be injected into the body.
• Clean Hands: Before using emedastine, wash your hands thoroughly to prevent any contamination.
• Avoid Touching: To prevent contamination, do not let the dropper tip touch your eyelids or any other surfaces when putting drops in your eyes.
• Remove Contact Lenses: Take out your contact lenses before using emedastine eye drops.
• Wait Before Reinserting Lenses: Wait at least 10 minutes before putting your contact lenses back in after using emedastine eye drops.
• Avoid Lenses with Red Eyes: If your eyes are red, it's best not to wear contact lenses until the redness goes away.

Mechanism of action of Emedastine (Emadine):

• Emedastine is a medication that works by blocking specific histamine receptors in the eyes, helping to relieve symptoms of allergies.
• It's meant to be used as eye drops only.
• When using emedastine, make sure your hands are clean, and avoid touching the dropper tip to prevent contamination.
• Take out your contact lenses before using the eye drops and wait at least 10 minutes before putting them back in.
• If your eyes are red, it's best not to wear contact lenses until the redness clears up.

Absorption:

• Ocular: Emedastine is absorbed very minimally when applied to the eyes.

Half-life Elimination:

• Oral:
  • Plasma: The time it takes for half of the emedastine to be eliminated from the bloodstream after oral administration is approximately 3 to 4 hours.

International Brand Names of Emedastine:

• Emadine
• Daren
• Emeromin
• Remicut SR

Emedastine Brand Names in Pakistan: