Indigo Carmine is an organic sodium salt, a synthetic color, that is used to localize ureteral orifices during cystoscopy and ureteral catheterization.
Indigo Carmine Uses:
-
Localization of ureteral orifices:
- It is used during cystoscopy and ureteral catheterization to localize ureteral orifices.
Indigo Carmine dose in adults:
Indigo Carmine Dose for the Localization of ureteral orifices:
- IM, IV (preferred):
- The usual dose is 5 mL;
- To avoid skin discoloration in underweight adults, doses of 5 mL or less are preferred.
Indigo Carmine dose in children:
Indigo Carmine Dose for Localizing ureteral orifices:
-
Infants and Children:
- IM, IV (preferred):
- The usual dose is less than 5 mL.
- Lower than usual doses may be required in underweight patients to avoid skin discoloration.
-
Adolescents:
- IM, IV (preferred):
- The usual dose is 5 mL.
- Patients who are small for age may be administered lower doses to prevent skin discoloration.
Pregnancy Risk Factor C
- Pregnant women have not been tested for the drug.
- If indicated, it should not be used during pregnancy.
Use during breastfeeding:
- It is unknown whether indigotindisulfonate salt sodium is excreted into breast milk.
- The manufacturer suggests that lactating mothers use the drug with caution.
Dose in Kidney Disease:
There are no dosage adjustments provided in the manufacturer’s labeling.
Dose in Liver disease:
There are no dosage adjustments provided in the manufacturer’s labeling.
Side effects of Indigo Carmine:
-
Cardiovascular:
- Bradycardia
- Hypertension
Contraindications:
Allergies to IndigotindisulfonateSodium
Warnings and precautions
-
Hypersensitivity reactions
- Rarely, idiosyncratic drug-related reactions can occur.
-
Effects of the pressor
- Mild pressure effects can occur during usage.
Monitoring Parameters:
None Mentioned.
How to administer Indigo carmine?
- The drug may be administered intravenously or intramuscularly. IV injections may be administered undiluted and are preferred.
- The solution should be inspected before administration for discoloration or precipitation of the solution.
- The contents of the solution should be withdrawn using 5-micron filters only.
Mechanism of action of Indigo Carmine:
Half-life elimination:
- IV injection: 4-5 minutes;
- IM injection: Delayed (comparable to IV administration).
Excretion:
- Urine usually appears in 10 minutes after IV administration. It retains its blue color.
International Brand Names:
- Indigo Carmine
Brand Names in Pakistan:
No Brands Available in Pakistan.
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