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Dear Readers! I started this blog when my daughter was in the NICU. She had ventriculitis. Her CSF report grew E.coli. But, she was injected Teicoplanin directly into her brain. The doctors made two errors here:

Teicoplanin is for gram-positive bacteria only. It does not treat E.coli.
Teicoplanin is not for intraventricular use. The manufacturer strongly discourage injecting Teicoplanin into the brain.

My daughter bled into the brain. She lived for another two years and ultimately died.

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Miconazole and Zinc Oxide (Vusion) - Uses, Dose, MOA, Brands

Miconazole and Zinc Oxide (Vusion) is a combination of antifungal medicine and zinc oxide that has antiseptic properties. It is used in the treatment of diaper dermatitis caused by candida.

Miconazole and Zinc Oxide (Vusion) Uses:

It is used as an adjunctive treatment of diaper dermatitis complicated by Candida albicans infection

Use in Adults:

Not indicated.

Miconazole and Zinc Oxide Dose in Childrens:

Miconazole and Zinc Oxide (Vusion) Dose in the treatment of Diaper dermatitis: Topical:

Children ≥4 weeks:
- Apply the cream to the affected area when changing the diaper each time for seven days.
- Continue the treatment for a total of seven days even if the improvement is noticed after the first few days.
- Do not exceed the treatment duration of seven days.

Pregnancy Risk Factor C

This combination has not been tested in human or animal pregnancies. It is not recommended for adults.
You can also see individual agents (Miconazole & Zinc Oxide).

Dose in Renal disease:

There are no manufacturer-recommended dose changes.

Dose in Liver disease:

No dosage adjustments are recommended by the manufacturer.

Side effects of Vusion:

Use may be associated with local burning, itching, dryness, redness, pain, and swelling. Avoid in patients who develop severe local reactions to the drug.

Contraindications to Vusion:

The manufacturer's labeling does not contain any contraindications.

Warnings and precautions

Irritation
- If there is irritation or sensitivity, discontinue treatment.

Drug Interaction

Risk Factor D (Consider therapy modification)
Anti-vitamin K substances (eg, warfarin)	Vitamin K antagonists' serum concentration may rise in response to topical miconazole.
Risk Factor X (Avoid combination)
Progesterone	Vaginal antifungal agents may reduce progesterone's therapeutic efficacy.

Monitoring Parameters:

None mentioned.

How to administer Vusion?

It is intended for topical use (external use) in children. It should be applied to the affected area after each diaper change.
The medicine should be applied to a dried and cleaned area. Avoid rubbing or using it over mucosal surfaces such as in the eyes, oral cavity, anal or vaginal orifices.
After applying the medicine, wash your hands. The use of scented or perfumed soaps, shampoos, or lotions should not be applied over the affected area. The diaper should be frequently changed.