MuGard (Oral mucosal barrier gel) is an oral non-adhesive wound rinse that is used as an oral mucosal protectant in patients with oral ulcers and mucositis.

MuGard (Oral mucosal barrier gel) Uses:

• Mucosal protection:

  • Irritation.
  • Because of tooth extractions, lesions, periodontal and gingival irritation, and oral surgery.
  • Chafing.
  • Treatment of oral mucosal discomfort brought on by chemotherapy or radiation therapy, as well as defence against further irritation brought on by oral mucositis or stomatitis.
  • Minor wounds.
  • Recurring aphthous ulcers (canker sores).
  • Traumatic ulcers and abrasions brought on by orthodontics, uncomfortable dentures, or illness.
  • Cough with pharyngitis (Orafate only).

MuGard (Oral mucosal barrier gel) Dose in Adults

Oral Mucosal Barrier Gel Dose in the Mucosal protection:

P/O:

• Episil:

  • • two to three times per day, or as necessary, administer one to three pumps to the oral cavity.
  • Max duration for continuous use:
    • 30 days

• Gelclair:

  • 15 millilitres of 1 single-use package dissolved in water should be rinsed, gargled, and spit out three times each day, or as needed.

• Mucotrol:

  • By swishing around in the mouth, slowly dissolve 1 wafer, 3 times every day or as required.

• MuGard:

  • Rinse with 5 milliliters 4-6 times everyday (for oral mucositis/stomatitis) or 4-6 times every day or as required (for other ulcerative conditions).
  • To fully coat inside of the mouth, it may use up to 10 milliliters if required.

Orafate:

• Recurrent Aphthous ulcers (canker sores):
  • Single/solitary group of ulcers:
  • Apply with cotton-tipped swab twice every day & at bedtime.
  • Ulcers throughout mouth:
    • Swish 5 milliliters in the mouth once every day or every 4-6 hours (severe cases).
• Following dental cleaning, scaling, root planing:
  • Brush 1.25-2.5 milliliter across the affected area of the gums daily for >4 weeks.
• Following tooth extraction or gingival (gum) surgery:
  • • Until healed, place 1.25-2.5 mL into wound 3 times every day the first day, then twice every day.
• Following tonsillectomy or other oral soft tissue surgery:
  • Place 2.5-5 milliliters into wound 3 times every day on the first day then twice every day.
• Oral inflammation around gums:
  • Until healed, brush 1.25-2.5 milliliter across the front and back of gingiva 2 times every day for the first day then once every day at bedtime.
• Pharyngitis, sore throat:
  • Swish 5 milliliters in mouth twice every day (in the morning after brushing teeth and at bedtime) or every 4-6 hours (severe cases).

ProThelial:

• Usual dosage:
  • On the first day, 2.5-5 milliliters every 8 hours.
  • 2.5-5 milliliter every 12 hours thereafter (max: 40 milliliters every day)
  • Prevention of chemo-radiation mucositis (beginning the first day of cancer treatment):
• Grade 1 or 2:
  • Until 1 week after completion of chemoradiation therapy, use 2.5-5 milliliters 3 times a day for 1 day, followed by 2.5-5 milliliters twice every day.
• Grade 3 or 4:
  • Continue until 1 week after completion of chemoradiation therapy, 10 milliliters 3 times a day.
  • Chemo-radiation mucositis treatment.
• Grade 1 or 2:
  • 2.5-5 milliliter 3 times a day for 1 day, followed by 2.5-5 milliliters twice every day until 1 week after completion of chemo-radiation therapy.
• Grade 3 or 4:
  • 10 milliliter 3 times a day for 2 days, followed by 5 to 10 mL twice every day until 1 week after completion of chemo-radiation therapy.

MuGard (Oral mucosal barrier gel) Dose in Children

MuGard (Oral Mucosal Barrier) Dose in the Mucosal protection:

• Children older than 12 years and Adolescents:

  • P/O:
  • Orafate:
  • Consider the adult Orafate dosage.

Pregnancy and lactation:

Since it is applied topically, it can be used safely in pregnancy and lactation.

Dose in Kidney disease:

It can be used in kidney disease since it is applied topically.

Dose in liver disease:

It can be used in liver disease since it is applied topically.

Side effects of MuGard/ orafate:

Local infections dystaste

Contraindications to MuGard (Oral mucosal barrier gel):

• Hypersensitivity to any ingredient of the formulation

Additional product-specific contraindications

• Episil:Hypersensitivity to soya, peanuts, and peppermint oil

Warnings and precautions

• Sublingual medication:

  • This may decrease the absorption sublingually administered medication.

Monitoring Parameters:

• Examine mucositis/ stomatitis symptoms/ severity.

How to administer MuGard (Oral mucosal barrier gel)?

Episil:

• Pump into a piece of paper until a steady stream is formed.
• Apply liquid stream to the mouth by pressing the pump 1-3 times. Once the gel has formed, wait for it to dry.
• Do not swallow
• Wait 5 minutes before eating or drinking.

Gelclair:

• Take before or after meals, or as directed.
• 15ml (1 single-use container) of water should be added. Stir well (refer to the product information for more details).
• Rinse around your mouth for a minute to thoroughly coat the tongue, palate and throat.
• Mix the ingredients together and spit it out.
• After treatment, you should avoid eating and drinking for at most 30-60 minutes.
• If water is unavailable, may be used undiluted.
• If you are unable to rinse, apply directly to your mouth with a sponge or cotton swab.
• Intentionally swallowed, there are no adverse effects.

Mucotrol:

• Water should be sipped around the mouth and allowed to dissolve slowly.
• After treatment, you should not eat or drink for at least one hour.

MuGard

• Allow the 5ml to sit in the mouth for at least one minute. Rinse the mouth with the rinse solution.
• You must ensure that every part of your oral cavity is coated.
• It may take up to 10ml to cover the entire mouth cavity.
• You may spit out or swallow any excess rinse.
• After treatment, you should not eat or drink for at least one hour.

Orafate

• Use the following methods to treat gum inflammation and other oral-related conditions.
• You can brush it alone, with toothpaste, or with a tongue depressor, a soft-bristled toothbrush, finger, or tongue depressor.
• Mix equal amounts of dentifrice powder, gel, or toothpaste and layer it over the soft tissue.
• Apply directly to the gum margin affected. Let it sit for 2 minutes, then gargle with spit.
• Apply a layer of toothpaste to the area. After 2 minutes, you can either manually remove it or spit it out.
• Place in mouth and gently suck between the teeth.
• For canker sores (multiple lesion), sore throat/pharyngitis, swish in the mouth for 10 seconds, then gargle.
• Safe to swallow
• Avoid eating or drinking after use for at least one hour.

ProThelial

• Place the paste in your mouth for 30 seconds.
• Apply the paste to the mucosa using the cotton-tipped swab or the tongue.
• You can either swish it and then expectorated, or you can swallow it.
• It can be combined (1:1) with yogurt or pudding, apple sauce, tapioca or ice cream to enhance its taste.
• Avoid eating or drinking after use for at least one hour.

Mechanism of action of MuGard (Oral mucosal barrier gel):

• Stick to the mucosal surface and create a protective coating or coating over the lesions and irritated areas. This protects the lesion against further irritation and pain.

International Brands of Oral mucosal barrier gel:

• Episil
• Gelclair
• Mucotrol
• MuGard
• Orafate
• ProThelial

Oral mucosal barrier gel Brand Names in Pakistan:

No Brands Available in Pakistan.