Nedocromil is a medication used to prevent and treat symptoms of asthma, such as wheezing, shortness of breath, and chest tightness. It belongs to a class of drugs called mast cell stabilizers, which work by preventing the release of certain chemicals in the body that can cause inflammation in the airways. Nedocromil is typically administered via an inhaler and is often used as a maintenance therapy for asthma rather than as a rescue medication for acute symptoms. It may take several weeks of regular use before its full benefits are realized.

Nedocromil (Alocril) inhibits the release of inflammatory mediators from cells including mast cells, eosinophils, neutrophils, and macrophages. It is used to treat patients with allergic conjunctivitis.

Nedocromil Uses:

• Allergic conjunctivitis:
  • Used for the treatment of itching associated with allergic conjunctivitis

Nedocromil (Alocril) Dose in Adults

Nedocromil (Alocril) eye drops dose in the treatment of Allergic conjunctivitis:

• When using nedocromil to treat allergic conjunctivitis (eye allergies), you typically put 1 to 2 drops in each eye two times a day.
• You keep doing this as long as you're exposed to whatever is causing your allergy symptoms.

Nedocromil (Alocril) Dose in Children

Nedocromil (Alocril) eye drops dose in the treatment of Allergic conjunctivitis:

• For children aged 3 years and older, as well as adolescents, the usual dose of nedocromil for treating allergic conjunctivitis is 1 to 2 drops in each eye two times a day. This should be continued throughout the period when they're exposed to the allergen causing their symptoms.

Pregnancy Risk Category: B

• While there haven't been well-controlled studies conducted in pregnant women, animal studies haven't shown any evidence of nedocromil causing harm to the fetus or being linked to birth defects.
• Also, because nedocromil is minimally absorbed into the bloodstream, the risk of it affecting the fetus is considered low.

Use during breastfeeding:

• Since it's not known whether nedocromil passes into breast milk, caution is advised when giving this medication to nursing women.
• The manufacturer suggests being careful in such cases.

Dose in Kidney Disease:

• The manufacturer's labeling for nedocromil doesn't provide specific dosage adjustments for individuals with renal impairment.
• However, because nedocromil is minimally absorbed into the bloodstream, dosage adjustments are unlikely to be necessary for people with kidney problems.

Dose in Liver disease:

• The manufacturer's labeling for nedocromil doesn't include specific dosage adjustments for individuals with hepatic (liver) impairment.
• However, because nedocromil is minimally absorbed into the bloodstream, dosage adjustments are unlikely to be needed for people with liver issues.

Common Side Effects of Nedocromil (Alocril):

• Central nervous system:
  • Headache
• Gastrointestinal:
  • Unpleasant taste
• Ophthalmic:
  • Burning sensation of eyes
  • Eye irritation
  • Stinging of eyes
• Respiratory:
  • Nasal congestion

Less Common Side Effects:

• Ophthalmic:
  • Conjunctivitis
  • Eye redness
  • Photophobia
• Respiratory:
  • Asthma
  • Rhinitis

Contraindication to Nedocromil (Alocril):

• If someone has a hypersensitivity (allergic reaction) to nedocromil or any component of the medication's formulation, they should not use it.
• It's crucial to avoid using nedocromil if you have a known allergy to it or any of its ingredients to prevent any adverse reactions.

Monitoring Parameters:

None mentioned. Monitor the response to treatment.

How to administer Nedocromil (Alocril)?

Important Guidelines for Using Nedocromil Eye Drops:

• Ophthalmic Use Only: Only use these eye drops in your eyes. Do not let the tip of the container touch your eyes, surrounding areas, your fingers, or any other surfaces. This helps prevent bacteria from getting into the drops.
• Avoid Contact Lenses: It's not recommended to wear contact lenses when you have symptoms of allergic conjunctivitis and are using these eye drops.

Mechanism of action of Nedocromil (Alocril):

• Nedocromil works by blocking the activation of various types of inflammatory cells that are involved in hypersensitivity reactions.
• These cells include eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets.
• By doing so, it prevents these cells from releasing inflammatory substances such as histamine, leukotrienes, and slow-reacting substance of anaphylaxis.
• This helps to reduce inflammation and symptoms associated with allergic reactions.

Absorption:

• Nedocromil has low absorption into the bloodstream, with less than 4% of the medication being absorbed.

Excretion:

• About 70% of nedocromil is excreted in urine in its unchanged form.
• Approximately 30% of the medication is excreted in feces without undergoing any changes.

International Brand Names of Nedocromil:

• Alocril
• Irtan
• Kovilen
• Kovinal
• Oftacril
• Rapitil
• Tilad
• Tilade
• Tilade CFC Free
• Tilade Mint
• Tilarin
• Tilavist

Nedocromil Brand Names in Pakistan:

No Brands Available in Pakistan.