Pramoxine is a topical anesthetic commonly used to relieve itching and minor skin irritations, such as insect bites, poison ivy, poison oak, poison sumac, minor burns, or cuts. It works by numbing the skin and reducing itching sensations. Pramoxine is available over-the-counter in various forms, including creams, lotions, sprays, and gels. It's generally considered safe when used as directed, but like any medication, it can cause side effects in some individuals, such as skin irritation or allergic reactions.

Pramoxine is a local anesthetic that is used for the symptomatic relief of pain, burning, and stinging associated with minor skin conditions and hemorrhoids.

Pramoxine Uses:

• It is used for the temporary relief of pain and itching associated with piles, burns, minor cuts, scrapes, or minor skin irritations.

Pramoxine dose in adults:

Dose in the treatment of minor skin irritation:

• If you're using a lotion or cream, put it on the irritated skin up to 3-4 times each day.
• Make sure to apply it directly to the area that's bothering you.
• Follow these instructions carefully to get the best results from the treatment.

Dose in the treatment of Hemorrhoidal itching:

• If you're using foam, ointment, or wipes, apply it to the affected area up to 5 times a day.
• Make sure to apply it directly to the area that's itchy and irritated.
• Follow these instructions carefully for effective relief from hemorrhoidal itching.

Use in Children:

Refer to adults dosing.

Use in pregnancy and lactation:

It has not been assigned a specific pregnancy category. Its use in human or animal pregnancy is not known. You should only use it if the benefits outweigh any risks.

Dose in Kidney disease:

No dosage adjustments have been mentioned. It may be used topically in patients with kidney disease.

Dose in liver disease:

No dosage adjustments have been mentioned. It may be used topically in patients with liver disease.

Side effects of Pramoxine:

• Local redness and erythema.
• Patients allergic to the drug may develop paradoxical pain, itching, redness, and stinging at the site.
• Dryness may occur at the site.

Contraindications and warnings:

No contraindications have been mentioned in the labeling. However, patients allergic to the drug should avoid using it.

Pramoxine: Drug Interaction

Monitoring Parameters:

None mentioned.

How to administer Pramoxine?

Cream:

• Do not put it near your eyes.

Lotion:

• Put it on the skin gently and use only as much as needed.

Foam:

• Shake it well before using.
• Clean and dry the area before applying.
• Put the foam on a clean tissue and use it outside your body. Don't put it inside.

Ointment:

• Don't put it inside your body.

Wipes:

• Clean and rinse the area before using.
• Gently pat the area with the wipe and throw it away after using it once.

Mechanism of action of Pramoxine:

• Pramoxine, similar to other anesthetics, works by reducing the ability of nerve cells to allow sodium ions to pass through their membranes.
• This action blocks both the start and transmission of nerve signals, preventing the neuron from depolarizing, which is a key step in nerve impulse transmission.

The beginning of action:

• Pramoxine typically starts working within 3 to 5 minutes after application.
• This means that you may begin to feel relief from itching or discomfort shortly after using it.

International Brand Names of Pramoxine:

• Calaclear
• Caladryl Clear
• Callergy Clear
• CeraVe Itch Relief
• Itch-X
• Ivy Wash Poison Ivy Cleanser
• PrameGel
• Pramox
• Prax
• Proctofoam
• Sarna Sensitive
• Anugesic
• Nestosyl
• Pramax Cream
• Primoly Gel
• Tronolane
• Tronotene
• Tronothane

Pramoxine Brand Names in Pakistan:

Tronolane cream (Abbott)