In individuals with congenital sucrase-isomaltase deficiency, sacrosidase (Sucraid), a naturally occurring digestive enzyme, is administered.
Sacrosidase Uses:
-
Congenital sucrase-isomaltase deficiency:
- When there is a sucrase deficit, such as in congenital sucrase-isomaltase deficiency, it is utilised as an oral replacement treatment (CSID)
Sacrosidase (Sucraid) Dose in Adults
Sacrosidase (Sucraid) Dose in the therapy of Congenital sucrase-isomaltase deficiency (CSID):
- Oral: 17,000 units (2 mL) per meal or snack
Sacrosidase (Sucraid) Dose in Childrens
Sacrosidase (Sucraid) Dose in the therapy of Congenital sucrose-isomaltase deficiency or sucrase deficiency:
Note: Half of the drug should be administered before snacks or meals and the rest should be administered within meals. The dosage should be calculated using the volume (mL) or drop count technique using the Sucraid bottle tip; in this example, 1 mL equals 28 drops.
-
Infants and Children less than 15 kg:
- 8,500 units taken orally (one mL is equal to 28 drops from the Sucraid container tip) for each meal or snack.
-
Children weighing more than 15 kg and Adolescents:
- 17,000 units (2 mL = 56 drops from Sucraid container tip) orally per meal or snack.
Pregnancy Risk Factor C
- It has not yet been tested in human or animal pregnancy studies.
- Fetal exposure is unlikely as the drug doesn't get absorbed. It should be administered only to pregnant women if strongly recommended.
Use during breastfeeding:
- The medication is initially broken down into amino acids in the stomach and intestines, and these amino acids are subsequently absorbed as peptides and nutrients.
Dose in Kidney Disease:
There are no dosage adjustments provided in the manufacturer's labeling.
Dose in Liver disease:
There are no dosage adjustments provided in the manufacturer's labeling.
Side Effects of Sacrosidase (Sucraid):
-
Endocrine & metabolic:
- Dehydration
-
Central nervous system:
- Headache
- Confusion
- Lack of sleep
-
Gastrointestinal:
- Diarrhea
- Nausea
- Abdominal pain
- Constipation
- Vomiting
Contraindications to Sacrosidase (Sucraid):
Allergies to glycerin, yeast, or goods made from yeast (glycerol)
Cautions and Alerts
-
Hypersensitivity reactions
- There have been reports of allergic reactions to the drug. Patients may develop bronchospasm.
- It is best to administer the first doses in a place where hypersensitivity reactions can quickly be managed.
- To identify patients at high risk for hypersensitivity reactions, skin testing may be done before the drug is administered.
-
Diabetes mellitus:
- Patients with diabetes should be cautious when using it, as it allows the absorption fructose/glucose.
Monitoring Parameters:
None mentioned.
How to administer Sacrosidase (Sucraid)?
- Orally, it is taken. You should dilute the dose in 60 to 120mL of chilled or room temperature milk, water, or formula.
- The drug's potency could be diminished if it is dissolved in fruit juices, hot or warm food and liquids.
- One-half should be administered at mealtime, while the other half can be taken as a snack or meal.
- You should measure the dose using the provided measuring scoop or the number of drops (counting method). One mL equals 28 drops at the bottle tip.
Mechanism of action of Sacrosidase (Sucraid):
- Sacrosidase, a naturally occurring enzyme in the gastrointestinal system, is derived from Saccharomyces cerevisiae.
- It is responsible for converting sucrose disaccharide to monosaccharide parts that can be absorbed by the GI tract.
Absorption:
- Amino acids
Metabolism:
- It is metabolized in the GI tract to individual amino acids.
International Brand Names of Sacrosidase:
- Sucraid
Sacrosidase Brand Names in Pakistan:
No Brands Available in Pakistan.
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