Systemic urea, often abbreviated as Ure-Na, refers to the level of urea in the bloodstream, typically measured in units of milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). Urea is a waste product formed in the liver during protein metabolism and is excreted by the kidneys through urine. Monitoring systemic urea levels can provide insights into kidney function, hydration status, and protein metabolism. Abnormal levels may indicate kidney dysfunction, dehydration, or other medical conditions.

Ure-Na is systemic urea available as an orally administered highly osmolar food item. It is used as a medical food for the management of euvolemic and hypervolemic hyponatremia. Urea is also available for topical application. Topical urea is used in the treatment of the following conditions:

• Dermatitis
• Psoriasis
• Dry and rough skin
• Skin cracks and fissures
• Xerosis
• Ichthyosis
• keratoderma
• Corns and calluses
• Eczema
• keratosis
• Damaged, ingrown, and devitalized nails.

Hyponatremia:

• "Hyponatremia" refers to low levels of sodium in the blood.
• It's a condition that can be caused by various factors, including too much water intake, certain medications, or health issues affecting the kidneys or hormones.

Note: "A medical food for the management of hyponatremia (euvolemic and hypervolemic)" likely refers to a specialized type of food or drink designed to help manage hyponatremia in people who have either normal fluid levels (euvolemic) or too much fluid in their bodies (hypervolemic). These products are typically formulated to help restore sodium levels in the body and improve overall health.

Ure-Na dose in Adults

Ure-Na dose in the treatment of Hyponatremia:

• The recommended dose for treating hyponatremia orally is between 15 to 60 grams per day.
• This dose can vary depending on factors such as the severity of the condition and individual patient needs.

Dose in Children:

The safety and efficacy of the drug in children have not been established. It is not recommended for use in children.

Pregnancy Risk Category: D

It should be avoided in pregnant and breastfeeding mothers.

Dose in kidney disease:

• The manufacturer's labeling does not include specific dosage adjustments for individuals with renal impairment.

Dose in liver disease:

• The absence of dosage adjustments for hepatic impairment in the manufacturer's labeling means that there are no specific recommendations for altering the dosage based on liver function as provided by the manufacturer.

Side effects of systemic Urea (Ure-Na):

• Endocrine & metabolic:
  • Hypernatremia
• Gastrointestinal:
  • Mildly upset stomach

Contraindications to systemic Urea Include:

• The absence of contraindications listed in the manufacturer's labeling indicates that there are no specific circumstances or conditions where the product should not be used according to the manufacturer's recommendations.

Monitor:

• Monitoring serum sodium levels is important for assessing hydration status and detecting conditions such as hyponatremia (low sodium levels) or hypernatremia (high sodium levels), which can indicate underlying health issues or imbalances in the body.

How to administer Urea (Ure-Na)?

• To prepare each 15-gram dose, mix it with 3 to 4 ounces of water or juice. This ensures that the dose is properly diluted for consumption.
• Mixing the dose with a liquid helps make it easier to swallow and may improve taste.

Mechanism of action of Systemic Urea (Ure-Na):

• Urea helps normalize serum sodium levels by promoting the excretion of excess free water through osmosis.
• This means it helps the body get rid of extra water, which can dilute sodium levels in the blood.
• Additionally, urea can improve hyponatremia in cases of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) through a more targeted mechanism.
• It does this by reducing the amount of sodium excreted in the urine while increasing urea concentration in the kidney's medulla, which helps to balance sodium levels more effectively.

International Brands of Systemic Urea:

• Ure-Na

Systemic Urea brand names in Pakistan:

No brand names are available in Pakistan.

Systemic urea, often abbreviated as Ure-Na, refers to the level of urea in the bloodstream, typically measured in units of milligrams per deciliter (mg/dL) or millimoles per liter (mmol/L). Urea is a waste product formed in the liver during protein metabolism and is excreted by the kidneys through urine. Monitoring systemic urea levels can provide insights into kidney function, hydration status, and protein metabolism. Abnormal levels may indicate kidney dysfunction, dehydration, or other medical conditions.

Ure-Na is systemic urea available as an orally administered highly osmolar food item. It is used as a medical food for the management of euvolemic and hypervolemic hyponatremia. Urea is also available for topical application. Topical urea is used in the treatment of the following conditions:

• Dermatitis
• Psoriasis
• Dry and rough skin
• Skin cracks and fissures
• Xerosis
• Ichthyosis
• keratoderma
• Corns and calluses
• Eczema
• keratosis
• Damaged, ingrown, and devitalized nails.

Hyponatremia:

• "Hyponatremia" refers to low levels of sodium in the blood.
• It's a condition that can be caused by various factors, including too much water intake, certain medications, or health issues affecting the kidneys or hormones.

Note: "A medical food for the management of hyponatremia (euvolemic and hypervolemic)" likely refers to a specialized type of food or drink designed to help manage hyponatremia in people who have either normal fluid levels (euvolemic) or too much fluid in their bodies (hypervolemic). These products are typically formulated to help restore sodium levels in the body and improve overall health.

Ure-Na dose in Adults

Ure-Na dose in the treatment of Hyponatremia:

• The recommended dose for treating hyponatremia orally is between 15 to 60 grams per day.
• This dose can vary depending on factors such as the severity of the condition and individual patient needs.

Dose in Children:

The safety and efficacy of the drug in children have not been established. It is not recommended for use in children.

Pregnancy Risk Category: D

It should be avoided in pregnant and breastfeeding mothers.

Dose in kidney disease:

• The manufacturer's labeling does not include specific dosage adjustments for individuals with renal impairment.

Dose in liver disease:

• The absence of dosage adjustments for hepatic impairment in the manufacturer's labeling means that there are no specific recommendations for altering the dosage based on liver function as provided by the manufacturer.

Side effects of systemic Urea (Ure-Na):

• Endocrine & metabolic:
  • Hypernatremia
• Gastrointestinal:
  • Mildly upset stomach

Contraindications to systemic Urea Include:

• The absence of contraindications listed in the manufacturer's labeling indicates that there are no specific circumstances or conditions where the product should not be used according to the manufacturer's recommendations.

Monitor:

• Monitoring serum sodium levels is important for assessing hydration status and detecting conditions such as hyponatremia (low sodium levels) or hypernatremia (high sodium levels), which can indicate underlying health issues or imbalances in the body.

How to administer Urea (Ure-Na)?

• To prepare each 15-gram dose, mix it with 3 to 4 ounces of water or juice. This ensures that the dose is properly diluted for consumption.
• Mixing the dose with a liquid helps make it easier to swallow and may improve taste.

Mechanism of action of Systemic Urea (Ure-Na):

• Urea helps normalize serum sodium levels by promoting the excretion of excess free water through osmosis.
• This means it helps the body get rid of extra water, which can dilute sodium levels in the blood.
• Additionally, urea can improve hyponatremia in cases of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) through a more targeted mechanism.
• It does this by reducing the amount of sodium excreted in the urine while increasing urea concentration in the kidney's medulla, which helps to balance sodium levels more effectively.

International Brands of Systemic Urea:

• Ure-Na

Systemic Urea brand names in Pakistan:

No brand names are available in Pakistan.