Diabetes Treatment

Author: owner     Published: 2 years ago 2 Replies

What are the differences between empagliflozin and dapagliflozin?

Dapagliflozin has FDA approved HF benefit while Empagliflozin has FDA approved CVD benefit. Dapagliflozin should be discontinued if eGFR falls below 60ml/min/1.73m² while Empagliflozin has a more wider renal safety window and can be given until eGFR falls below 45ml/min/1.73m². Empagliflozin has slightly higher reduction in HbA1c as compared to Dapagliflozin. 

Hira Tahir, 2 years ago

Dapagliflozin is a non-selective SGLT-2 inhibitor. Empagliflozin is 5000 times more SGLT-2 selective than dapagliflozin. Since SGLT-1 receptors are present in the heart, dapagliflozin is more effective in patients with heart failure.

Dr. Ahmed Farhan, 2 years ago

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