Arterial pH <7.3 after resuscitation and 24 h since ingestion

Three following criteria:

• Hepatic encephalopathy grades 3–4

• Serum creatinine >300 mol/L (3.4 mg(dl)

• INR >6.5

INR >6.5

Three out of five following criteria:

• Etiology: indeterminate etiology hepatitis, drug-induced hepatitis

• Age <10 years or >40 years

• Interval jaundice encephalopathy >7 days

• Bilirubin >300 mol/L (17 mg/dl)

• INR >3.5