Epinastine is an antihistamine medication primarily used to treat allergic conjunctivitis, which is inflammation of the eye caused by allergies. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms such as itching, redness, and swelling.

Epinastine is commonly available in the form of eye drops and is usually applied directly to the affected eye(s). It provides relief from symptoms such as itching and redness associated with allergic conjunctivitis.

Epinastine (Elestat) is a second-generation antihistamine and a mast cell stabilizer that is used in the treatment of allergic eye disease.

Epinastine (Elestat) Uses:

• It is used in the treatment of allergic conjunctivitis.

Epinastine (Elestat) Dose in Adults

Epinastine (Elestat) Dose in allergic conjunctivitis:

• For allergic conjunctivitis, you typically use epinastine eye drops by putting one drop in each eye two times a day.
• You should keep using it regularly, even if your eyes feel better, as long as you're still exposed to allergens that can cause your symptoms.

Epinastine (Elestat) Dose in Childrens

Epinastine (Elestat) Dose in allergic conjunctivitis in children:

• For kids aged 2 years and older, as well as teenagers, who have allergic conjunctivitis, the usual dose of epinastine is to put one drop into each eye two times a day.
• You should keep using it regularly, even if the symptoms go away, as long as they're still exposed to things that cause their allergies.

Pregnancy Risk Factor C

• When it comes to pregnancy, epinastine falls under category C, meaning there haven't been enough studies in pregnant women to know its effects.
• However, in animal studies, it didn't show any harmful effects on the baby's development.
• Overall, there's not enough data to say for sure how safe it is during pregnancy.

Use epinastine while breastfeeding

• It's uncertain whether epinastine passes into breast milk, so it's not clear if it can affect the baby.
• The manufacturer suggests being cautious if giving epinastine to nursing mothers.

Epinastine (Elestat) Dose in Kidney disease:

• The manufacturer's instructions don't mention adjusting the dosage of epinastine.
• This is likely because it's absorbed into the body at very low levels, so it's unlikely to cause any significant effects that would require a dosage change.

Epinastine (Elestat) Dose in Liver disease:

• The manufacturer's instructions don't include adjusting the dosage of epinastine for people with liver problems.
• This is probably because epinastine is absorbed into the body at very low levels, so liver issues are unlikely to affect its effectiveness or safety.

Side Effects of Epinastine (Elestat):

• Central nervous system:
  • Headache
• Infection:
  • Infection
• Ophthalmic:
  • Burning sensation of eyes
  • Eye pruritus
  • Follicular conjunctivitis
  • Ocular hyperemia
• Respiratory:
  • Cough
  • Pharyngitis
  • Rhinitis
  • Sinusitis

Contraindications to Epinastine (Elestat):

There are no specific conditions or situations listed in the manufacturer's instructions where epinastine should not be used.

Warnings and precautions

Bacterial Keratitis

• Bacterial keratitis, an infection of the cornea, has been reported due to accidental contamination of multi-dose eye drops.

Monitoring Parameters:

None mentioned in the manufacturer's labeling. Monitor the response to treatment.

How to administer Epinastine (Elestat)?

• Epinastine is meant for use in the eyes only; avoid touching the tip of the applicator to the eye or any other surfaces to prevent contamination.
• Remove contact lenses before using the eye drops, and you can put them back in after waiting for 10 minutes.
• However, if your eyes are red, it's best not to wear contact lenses.

Mechanism of action of Epinastine (Elestat):

• Epinastine is a selective H1-receptor antagonist, which means it blocks the action of histamine, a substance involved in allergic reactions, by targeting specific receptors in the body.
• It inhibits the release of histamine from mast cells, which are involved in allergic responses.
• Additionally, epinastine also interacts with other receptors in the body, including the H2, alpha1, alpha2, and 5-HT receptors.

Onset of action:

• It typically starts working within 3 to 5 minutes after application.

Duration:

• Its effects usually last for about 8 hours.

Absorption:

• Epinastine is minimally absorbed into the bloodstream after applying it topically to the eye.

Distribution:

• It does not cross the blood-brain barrier.

Protein binding:

• Approximately 64% of epinastine binds to proteins in the bloodstream.

Metabolism:

• Less than 10% of epinastine is metabolized in the body.

Half-life elimination:

• The half-life of epinastine, the time it takes for half of the drug to be eliminated from the body, is around 12 hours.

Excretion:

• After intravenous administration, about 55% of epinastine is eliminated in the urine, while approximately 30% is excreted in the feces.

International Brand Names of Epinastine:

• Elestat
• Alesion
• Alket
• Allerginon
• Alpatin
• Aresten
• Atergit
• Elestat
• Epigen
• Epinast
• Flurinol
• Furinol
• Karmastin
• Optest
• Purivist
• Relestat
• Statergic
• Talerc

Epinastine Brand Names in Pakistan:

No Brands Available in Pakistan.

Epinastine is an antihistamine medication primarily used to treat allergic conjunctivitis, which is inflammation of the eye caused by allergies. It works by blocking the action of histamine, a substance in the body that causes allergic symptoms such as itching, redness, and swelling.

Epinastine is commonly available in the form of eye drops and is usually applied directly to the affected eye(s). It provides relief from symptoms such as itching and redness associated with allergic conjunctivitis.

Epinastine (Elestat) is a second-generation antihistamine and a mast cell stabilizer that is used in the treatment of allergic eye disease.

Epinastine (Elestat) Uses:

• It is used in the treatment of allergic conjunctivitis.

Epinastine (Elestat) Dose in Adults

Epinastine (Elestat) Dose in allergic conjunctivitis:

• For allergic conjunctivitis, you typically use epinastine eye drops by putting one drop in each eye two times a day.
• You should keep using it regularly, even if your eyes feel better, as long as you're still exposed to allergens that can cause your symptoms.

Epinastine (Elestat) Dose in Childrens

Epinastine (Elestat) Dose in allergic conjunctivitis in children:

• For kids aged 2 years and older, as well as teenagers, who have allergic conjunctivitis, the usual dose of epinastine is to put one drop into each eye two times a day.
• You should keep using it regularly, even if the symptoms go away, as long as they're still exposed to things that cause their allergies.

Pregnancy Risk Factor C

• When it comes to pregnancy, epinastine falls under category C, meaning there haven't been enough studies in pregnant women to know its effects.
• However, in animal studies, it didn't show any harmful effects on the baby's development.
• Overall, there's not enough data to say for sure how safe it is during pregnancy.

Use epinastine while breastfeeding

• It's uncertain whether epinastine passes into breast milk, so it's not clear if it can affect the baby.
• The manufacturer suggests being cautious if giving epinastine to nursing mothers.

Epinastine (Elestat) Dose in Kidney disease:

• The manufacturer's instructions don't mention adjusting the dosage of epinastine.
• This is likely because it's absorbed into the body at very low levels, so it's unlikely to cause any significant effects that would require a dosage change.

Epinastine (Elestat) Dose in Liver disease:

• The manufacturer's instructions don't include adjusting the dosage of epinastine for people with liver problems.
• This is probably because epinastine is absorbed into the body at very low levels, so liver issues are unlikely to affect its effectiveness or safety.

Side Effects of Epinastine (Elestat):

• Central nervous system:
  • Headache
• Infection:
  • Infection
• Ophthalmic:
  • Burning sensation of eyes
  • Eye pruritus
  • Follicular conjunctivitis
  • Ocular hyperemia
• Respiratory:
  • Cough
  • Pharyngitis
  • Rhinitis
  • Sinusitis

Contraindications to Epinastine (Elestat):

There are no specific conditions or situations listed in the manufacturer's instructions where epinastine should not be used.

Warnings and precautions

Bacterial Keratitis

• Bacterial keratitis, an infection of the cornea, has been reported due to accidental contamination of multi-dose eye drops.

Monitoring Parameters:

None mentioned in the manufacturer's labeling. Monitor the response to treatment.

How to administer Epinastine (Elestat)?

• Epinastine is meant for use in the eyes only; avoid touching the tip of the applicator to the eye or any other surfaces to prevent contamination.
• Remove contact lenses before using the eye drops, and you can put them back in after waiting for 10 minutes.
• However, if your eyes are red, it's best not to wear contact lenses.

Mechanism of action of Epinastine (Elestat):

• Epinastine is a selective H1-receptor antagonist, which means it blocks the action of histamine, a substance involved in allergic reactions, by targeting specific receptors in the body.
• It inhibits the release of histamine from mast cells, which are involved in allergic responses.
• Additionally, epinastine also interacts with other receptors in the body, including the H2, alpha1, alpha2, and 5-HT receptors.

Onset of action:

• It typically starts working within 3 to 5 minutes after application.

Duration:

• Its effects usually last for about 8 hours.

Absorption:

• Epinastine is minimally absorbed into the bloodstream after applying it topically to the eye.

Distribution:

• It does not cross the blood-brain barrier.

Protein binding:

• Approximately 64% of epinastine binds to proteins in the bloodstream.

Metabolism:

• Less than 10% of epinastine is metabolized in the body.

Half-life elimination:

• The half-life of epinastine, the time it takes for half of the drug to be eliminated from the body, is around 12 hours.

Excretion:

• After intravenous administration, about 55% of epinastine is eliminated in the urine, while approximately 30% is excreted in the feces.

International Brand Names of Epinastine:

• Elestat
• Alesion
• Alket
• Allerginon
• Alpatin
• Aresten
• Atergit
• Elestat
• Epigen
• Epinast
• Flurinol
• Furinol
• Karmastin
• Optest
• Purivist
• Relestat
• Statergic
• Talerc

Epinastine Brand Names in Pakistan:

No Brands Available in Pakistan.