Naphazoline is a medication used primarily as a decongestant to relieve redness, itching, and watering of the eyes due to minor eye irritations (e.g., smog, swimming, dust, or smoke). It belongs to a class of drugs known as sympathomimetic amines. Naphazoline works by narrowing the blood vessels in the eye, thereby reducing swelling and redness.

Naphazoline is a sympathomimetic drug used that causes vasoconstriction by activating the alpha-adrenergic receptors. It is used as a temporary treatment for the symptomatic treatment of redness, swelling, itching, and tearing associated with ocular allergies.

Naphazoline Dose in Adults

Naphazoline Dose in the treatment of Ocular redness and allergies:  

• Put one or two drops in the affected eye(s) every 3 to 4 hours, or less often if needed.
• Make sure to follow these instructions carefully for the best results.

Naphazoline Dose in Children

Not recommended for use in children

Pregnancy Risk Factor: C

• It has not been studied in pregnancy and breastfeeding and is classified as category C during pregnancy.

Naphazoline Dose in Renal Disease:

• There are no specific dosage adjustments provided in the manufacturer's labeling for naphazoline in cases of kidney disease.

Naphazoline Dose in Liver Disease:

• The manufacturer's labeling for naphazoline does not include dosage adjustments for liver disease.

Severe side effects of naphazoline:

keratitis, ocular hypertension, coma, and bradycardia

Moderate side effects:

Hypertension, Blurred vision, Hyperglycemia, Respiratory depression, Hypotension, and Sinus tachycardia

Mild side effects:

Mydriasis, lacrimation, ocular irritation, hyperhidrosis, drowsiness, weakness, headache, dizziness, nausea, lethargy, vomiting, and hypothermia.

Contraindication to Naphazoline Include:

• If someone is allergic to naphazoline, antazoline, or any part of the medicine, or if they have glaucoma, they shouldn't use it.
• It's also not recommended for children unless a doctor advises it.
• If you're unsure about using it or have any concerns, it's best to talk to a doctor for guidance.

Warnings and Precautions

Cardiovascular disease

• If someone has heart problems or high blood pressure, they should be careful when using naphazoline because it can raise blood pressure due to its effects on the body

Diabetes:

• If someone has diabetes, they should use naphazoline cautiously.
• It's important because it can affect blood sugar levels, which is crucial for people managing diabetes.

Thyroid disease:

• For individuals with hyperthyroidism, it's important to be cautious when using naphazoline.
• This is because the medication can have effects on the body that may interact with the condition.

Monitoring Parameters:

Monitor for improvement or worsening of the symptoms.

How to administer Naphazoline?

• When using naphazoline eye drops, it's important to follow these steps for safe administration: First, wash your hands.
• Make sure not to touch the tip of the container to your eye to prevent contamination.
• If you wear contact lenses, remove them before using the eye drops.
• After putting in the drops, wait for a bit before putting your contact lenses back in.
• Also, don't insert your contacts if your eyes are still red.
• These precautions help ensure the effectiveness of the treatment and reduce the risk of irritation or infection.

Naphazoline Mechanism of action of Naphazoline:

• Naphazoline works by stimulating alpha-adrenergic receptors in the small blood vessels (arterioles) of the conjunctiva, which helps to narrow these blood vessels and reduce redness and swelling in the eyes.
• On the other hand, antazoline acts by inhibiting the effects of histamine on conjunctival epithelial cells.
• Histamine is a chemical released during allergic reactions, and its effects can include itching, redness, and swelling.
• By blocking histamine's effects, antazoline helps to alleviate these allergic symptoms in the eyes.
• Together, these mechanisms make naphazoline and antazoline combination eye drops effective in relieving eye redness and itching caused by various factors, including allergies.

Naphazoline international brands:

• Albalon-A
• Alergiftalmina
• Alergoftal
• Antistin-Privin
• Antistin-Privina
• Apihist
• Dermophenazol
• Midazol Ofteno
• Nazolin
• Noscam
• Ocured
• Oftalirio
• Oftophenazol
• Ophtazolin
• Orthophenazole
• Refresh Eye Allergy Relief
• Red Off Plus
• Rhinophenazol
• Sanorin-Analergin
• Sesal
• Zolinox

Naphazoline Brands in Pakistan