Indigo Carmine is an organic sodium salt, a synthetic color, that is used to localize ureteral orifices during cystoscopy and ureteral catheterization.

Indigo Carmine Uses:

• Localization of ureteral orifices:

  • It is used during cystoscopy and ureteral catheterization to localize ureteral orifices.

Indigo Carmine dose in adults:

Indigo Carmine Dose for the Localization of ureteral orifices:

• IM, IV (preferred):
• The usual dose is 5 mL;
• To avoid skin discoloration in underweight adults, doses of 5 mL or less are preferred.

Indigo Carmine dose in children:

Indigo Carmine Dose for Localizing ureteral orifices:

• Infants and Children:

  • IM, IV (preferred):
  • The usual dose is less than 5 mL.
  • Lower than usual doses may be required in underweight patients to avoid skin discoloration.

• Adolescents:

  • IM, IV (preferred):
  • The usual dose is 5 mL.
  • Patients who are small for age may be administered lower doses to prevent skin discoloration.

Pregnancy Risk Factor C

• Pregnant women have not been tested for the drug.
• If indicated, it should not be used during pregnancy.

Use during breastfeeding:

• It is unknown whether indigotindisulfonate salt sodium is excreted into breast milk.
• The manufacturer suggests that lactating mothers use the drug with caution.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Dose in Liver disease:

There are no dosage adjustments provided in the manufacturer’s labeling.

Side effects of Indigo Carmine:

• Cardiovascular:

  • Bradycardia
  • Hypertension

Contraindications:

Allergies to IndigotindisulfonateSodium

Warnings and precautions

• Hypersensitivity reactions

  • Rarely, idiosyncratic drug-related reactions can occur.

• Effects of the pressor

  • Mild pressure effects can occur during usage.

Monitoring Parameters:

None Mentioned.

How to administer Indigo carmine?

• The drug may be administered intravenously or intramuscularly. IV injections may be administered undiluted and are preferred.
• The solution should be inspected before administration for discoloration or precipitation of the solution.
• The contents of the solution should be withdrawn using 5-micron filters only.

Mechanism of action of Indigo Carmine:

Half-life elimination:

• IV injection: 4-5 minutes;
• IM injection: Delayed (comparable to IV administration).

Excretion:

• Urine usually appears in 10 minutes after IV administration. It retains its blue color.

International Brand Names:

• Indigo Carmine

Brand Names in Pakistan:

No Brands Available in Pakistan.