Tavaborole is a medication used in the treatment of onychomycosis, a fungal infection of the nails. It's typically available as a topical solution and works by inhibiting fungal protein synthesis. Tavaborole is applied directly to the affected nails, penetrating the nail plate to reach the site of infection. It's often prescribed as a first-line treatment for mild to moderate cases of toenail fungus.

Kerydin (Tavaborole) is a topical antifungal agent that inhibits tRNA synthetase.

Onychomycosis of the toenails caused by Trichophyton rubrum and Trichophyton mentagrophytes is treated topically with it.

Treatment of fungal skin infections - a case scenario

Kerydin (Tavaborole) Dose in Adults

Kerydin (Tavaborole) Dose in the treatment of Onychomycosis:

• It comes in a solution that you put directly on the affected toenail once a day.
• You'll want to keep doing this every day for about 48 weeks, which is a long time, but it helps make sure the fungus is gone.

Kerydin (Tavaborole) Dose in Children

Kerydin (Tavaborole) Dose in the treatment of Onychomycosis: Topical:

• Children ≥6 years of age and Adolescents:
  • Refer to adult dosing.

Pregnancy Risk Factor: C

• In some studies done on animals, there were some negative effects noticed during their pregnancies or when they were trying to have babies.

Tavaborole use during breastfeeding:

• We're not sure if tavaborole passes into breast milk after it's applied.
• The decision about whether to keep breastfeeding while using this treatment should consider a few things.
• It's important to weigh the risk of the baby being exposed to the medication against the benefits of breastfeeding for the baby and the benefits of the treatment for the mother.

Kerydin (Tavaborole) dose in kidney disease:

• The manufacturer's instructions don't mention any changes in dosage for people with kidney problems.
• This is because tavaborole is unlikely to be absorbed into the body in large amounts, so it's not expected to have much impact on the kidneys.
• Therefore, there's usually no need to adjust the dosage for people with kidney issues.

Kerydin (Tavaborole) dose in liver disease:

• The instructions from the manufacturer don't include any changes in dosage for people with liver issues.
• This is because tavaborole is not expected to be absorbed into the body in large amounts, so it's unlikely to affect the liver.
• Therefore, there's usually no need to adjust the dosage for people with liver problems.

Side Effects of Kerydin (Tavaborole):

• Dermatologic:
  • Ingrown nail
• Local:
  • Local skin exfoliation
  • Application site erythema
  • Application-site dermatitis

Contraindications to Kerydin (Tavaborole):

• The manufacturer's instructions don't mention any specific situations where tavaborole should not be used.

Warnings and precautions

Local irritation

• Sometimes, when you use tavaborole, you might notice irritation right where you apply it.
• This could mean your skin becomes red, starts to peel, or you get a rash.
• If this happens and it doesn't go away, it's important to let your doctor know.
• They can give you advice on what to do next and whether you should keep using the medication.

Monitor:

None required

How to administer Kerydin (Tavaborole)?

How to Apply Tavaborole Topical Solution

• Preparation: Make sure your affected toenails are clean and dry before you start.
• Application: Use the provided dropper to apply the solution. Cover the entire surface of the affected toenail and also put some under the tip of each affected toenail.
• Avoid Contact: Be careful not to get the solution on other parts of your skin. If you do, wipe away the extra solution and let it dry.
• Hand Hygiene: After applying the solution, wash your hands thoroughly with soap and water.

Mechanism of action of Tavaborole (Kerydin):

• Tavaborole is a type of antifungal medication known as an oxaborole.
• It works by stopping the fungus from making proteins.
• It does this by blocking a specific enzyme called aminoacyl-transfer ribonucleic acid (tRNA) synthetase (AARS), which the fungus needs to build its proteins.
• This action helps to kill the fungus and treat the infection.

Metabolism:

• Tavaborole undergoes extensive metabolism in the body, meaning it's broken down into smaller molecules.

Excretion:

• The remnants are eliminated from the body mainly through urine.

International Brands of Tavaborole:

• Kerydin

Tavaborole Brand Names in Pakistan:

It is not available in Pakistan.