Miconazole Nitrate (Daktarin) is available as a cream, ointment, and Gel (intravaginal Gel). It is used to treat superficial skin and mucosal/ vaginal fungal infections.

Miconazole Nitrate (Daktarin) Uses:

• For treating vulvovaginal candidiasis and many skins and mucous membrane fungal infections

Miconazole Nitrate Dose in Adults:

Dosage of miconazole nitrate for Tinea corporis:

• Topical: Apply twice daily for 1 month

Miconazole Nitrate Dose in the treatment of Tinea cruris:

• Topical: Apply two times a day for 14 days

Miconazole Nitrate Dose in the treatment of Tinea pedis:

• Topical: Apply twice daily for 1 month
  • Effervescent tablet: Dissolve 1 tablet in ~1 gallon of water; soak feet for half an hour

Miconazole Dose in the treatment of Vulvovaginal candidiasis: Intravaginal:

• Suppository, 1,200 mg:
  • Insert 1 suppository ( single dose)
• Suppository, 100 mg:
  • Insert 1 suppository at bedtime for 1 week
• Suppository, 200 mg:
  • Insert 1 suppository at bedtime for 3 days
• Cream, 4%:
  • Insert 1 applicatorful at bedtime for 3 days
• Cream, 2%:
  • Insert 1 applicatorful at bedtime for 1 week

Miconazole Nitrate dose in Children:

Treatment of superficial dermatologic infection with miconazole nitrate dosage:

• Ointment: Children over 2 years old and adolescents

  • Topical: Do this twice daily in the afflicted region.

Miconazole Nitrate Dose in the treatment of Tinea pedis:

• Adolescents and Children Over 2 Years Old:

  • Topical ointment, cream, spray, powder, aerosol, or solution: Topical:
    • Apply twice daily for 1 month

Miconazole Nitrate Dose in the treatment of Tinea corporis:

• Adolescents and Children Over 2 Years Old:

  • Topical ointment, cream, spray, powder, aerosol, or solution: Topical:
    • Apply twice daily for 1 month

Miconazole Nitrate Dose in the treatment of Tinea cruris:

• Adolescents and Children Over 2 Years Old:

  • Topical ointment, cream, spray, powder, aerosol, or solution: Topical:
    • Apply two times a day for 14 days

Miconazole Dose in the treatment of Vulvovaginal candidiasis:

• Children ≥12 years and Adolescents: Intravaginal:

  • Suppository, 100 mg:
    • Insert 1 suppository at bedtime for 1 week
  • Cream 4%:
    • Insert 1 applicatorful (200 mg) at bedtime for 3  days
  • Suppository, 200 mg:
    • Insert 1 suppository at bedtime for 3 days
  • Cream 2%:
    • Insert 1 applicatorful (100 mg) at bedtime for 1 week
  • Suppository, 1,200 mg:
    • Insert 1 suppository (single use)

Miconazole Pregnancy Category: C

• Vaginal administration can cause a small amount of systemic absorption.
• Topical azole products for vulvovaginal candidiasis in the uterus (7-day treatments only) are recommended.
• Vaginal products can alter the effectiveness of latex condoms or diaphragms.

Miconazole use during breastfeeding:

• Unknown. It is possible to use topical applications that result in minimal systemic absorption.

Dose in Kidney Disease:

No dosage modification is required.

Dose in Liver disease:

No dosage modification is required.

Side effects of Topical Miconazole Nitrate (Daktarin):

Topical:

• Dermatologic:

  • Maceration of skin
  • Allergic contact dermatitis
  • Burning sensation on the skin

Vaginal:

• Genitourinary:

  • Vulvovaginal burning
  • Vulvovaginal pruritus
  • Vulvovaginal irritation

• Gastrointestinal:

  • Abdominal cramps

Contraindications to Topical Miconazole Nitrate (Daktarin):

Sensitivity to any ingredient in the formulation, including miconazole

Cautions and Alerts

• Irritation

  • If irritation occurs, discontinue use.

Miconazole (topical): Drug Interaction

Risk Factor C (Monitor therapy)
Progesterone	Vaginal antifungal agents may reduce progesterone's therapeutic efficacy.
Risk Factor D (Consider therapy modification) Pure Organic Berberine Powder
Anti-vitamin K substances (eg, warfarin)	Vitamin K antagonists' serum concentration may rise in response to topical miconazole.

Monitoring Parameters:

None mentioned. Monitor the response to treatment.

How to apply Topical Miconazole (Daktarin)?

It is applied once daily over the affected area. Vaginal cream may be applied once a day at bedtime inside or around the vagina for a minimum of three consecutive days.

Mechanism of action of Miconazole Nitrate (Daktarin):

It decreases the production of ergosterol, which causes fungal cell wall permeability to be altered. This leads to increased protein and nutrient loss.

Absorption:

• Vaginal: Small amount absorbed systemically
• Topical: Negligible;

Metabolism:

• In the liver

Distribution:

• Sputum, saliva, urine, and CSF; low penetration into bodily tissues, joints, and fluids

Excretion:

• Feces (~50%);
• urine (<1%, unchanged)

Protein binding:

• 91% to 93%

Half-life elimination:

• Multiphasic degradation:
  • Alpha: 40 minutes;
  • Terminal: 24 hours
  • Beta: 126 minutes;

International Brand Names of Topical Miconazole:

• Aloe Vesta Antifungal
• GoodSense Miconazole 1
• Cavilon
• Cruex Prescription Strength
• Miconazole 3
• Miconazole 3 Combo Pack
• DermaFungal
• Lotrimin AF Jock Itch Powder
• Desenex
• Lotrimin AF Powder
• Remedy Phytoplex Antifungal
• Azolen Tincture
• Baza Antifungal
• Lotrimin AF
• Micaderm
• Critic-Aid Clear AF
• Micatin
• Secura Antifungal
• Lotrimin AF Deodorant Powder
• Secura Antifungal Extra Thick
• Adcozole
• Aloid
• Soothe & Cool INZO Antifungal
• Miconazole 7
• Vagistat-3
• Aloe Vesta Clear Antifungal
• Carrington Antifungal
• Triple Paste AF
• Zeasorb-AF
• Miconazole Antifungal
• Micro Guard
• Bai Ni Duo
• Becarin
• Beikang
• Brentan
• Candiplas
• Podactin
• Remedy Antifungal Clear3
• Candizol
• Candizol oral
• Desenex Jock Itch
• Candizole
• Ciconazol
• Conazol
• Dafrin
• Daktar
• Daktarin
• Daktazol
• Decozol
• Defungin
• Deralbine
• Dermizol
• Dermon
• Dermozole
• Remedy Antifungal
• Ao Xian Ning
• Dexatrim
• Eulactol Antifungal Spray
• Fungoid Tincture
• Funazol
• Fungares
• Fungiderm
• Fungisdin Aerosol
• Fungtopic
• Fungyzole
• Gyno-Daktarin
• Hipo Femme
• Hongosan Crema
• Iniderm
• Meconazole
• Medskin
• Menazan
• Micane
• Micatin
• Micer
• Mico
• Micoban
• Micoderm
• Micofim
• Micogel
• Micoglen
• Miconaz
• Miconazol
• Miconex
• Miconol
• Micopul
• Micotar
• Micotral
• Micotrin
• Micover
• Micozol
• Micozole
• Micreme
• Mikozal
• Mitigal
• Mizonol
• Moladerm
• Resolve Tinea
• Rojazol
• Monizol
• Mycoheal Cream
• Mycosolon
• Mycozol Cream
• Mykoderm
• Neomicol
• Niscamil
• Resolve Jock Itch
• Resolve Solution
• Nocand
• Noxrakin
• Pitrion
• Resolve
• Resolve Thrush
• Skindure
• Tara
• Untano
• Zarin
• Zimycan
• Zole

Miconazole Brand Names in Pakistan: