Disclaimer Notice:

Dear Readers! I started this blog when my daughter was in the NICU. She had ventriculitis. Her CSF report grew E.coli. But, she was injected Teicoplanin directly into her brain. The doctors made two errors here:

Teicoplanin is for gram-positive bacteria only. It does not treat E.coli.
Teicoplanin is not for intraventricular use. The manufacturer strongly discourage injecting Teicoplanin into the brain.

My daughter bled into the brain. She lived for another two years and ultimately died.

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Ozenoxacin Cream (Xepi) - Uses, Dose, MOA, Brands, Side effects

Ozenoxacin Cream (Xepi) is a quinolone antibiotic that is used as a topical cream for the treatment of impetigo in children and adults.

Ozenoxacin Cream Uses:

Impetigo:
- It is approved for the treatment of adult and paediatric patients 2 months of age and older with impetigo brought on by Staphylococcus aureus or Streptococcus pyogenes.

Ozenoxacin Cream (Xepi) Dose in Adults

Ozenoxacin Cream (Xepi) Dose in the treatment of Impetigo:

Two times daily for five days, it is topically administered in a thin layer to the afflicted area.
There should be no more than 100 cm2 in total.

Ozenoxacin Cream (Xepi) Dose in Children

Dosage of oznoxacin cream (Xepi) for impetigo in children older than 2 months:

For five days, the affected area receives two applications of a thin coating each time.
Note: For patients under the age of 12, the total afflicted area may be up to 2% of the total BSA, but it should not exceed 100 cm2.

Pregnancy Category: N (not assigned)

Topical application is not a means of exposing fetal to systemic or systemic radiation.

Use during breastfeeding:

It is unknown if the drug will be excreted into breast milk. The drug cannot be absorbed topically so it is unlikely that the drug will get into breastmilk.
It is recommended that pregnant women use it with caution, considering the possible risks to the baby and the benefits for the mother.

Dose in Kidney Disease:

There are no dosage adjustments provided in the manufacturer's labeling. However, dosage adjustment is unlikely due to low systemic absorption.

Dose in Liver Disease:

The manufacturer's labelling does not mention dosage modifications. However, due to limited systemic absorption, dosage modification is improbable.

Side effects of Ozenoxacin Cream (Xepi):

Skin itching
Dryness
peeling of the skin
redness
flaking of the skin

Contraindications to Ozenoxacin Cream (Xepi):

The manufacturer's labeling does not list any contraindications. Patients with allergies to any ingredient or medicine should stay away, according to Canadian labelling.

Warnings and precautions

Superinfection
- Long-term use can result in superinfections with bacteria and fungi that may not cure. If superinfections develop, the treatment should be stopped immediately.