Sulfur and salicylic acid (Pernox) cause keratolysis and are used in the treatment of patients with psoriasis and dandruff (seborrheic dermatitis).

Sulfur and salicylic acid Uses:

• Dermatological conditions:

  • It is indicated for the symptomatic control of dandruff, seborrheic dermatitis, and psoriasis.

Sulfur and salicylic acid (Pernox) Dose in Adults

Sulfur and salicylic acid (Pernox) Dose in the Dermatological conditions:

• Topical application:
  • Wet the scalp or the affected skin and massage enough of the shampoo to form a lather. Massage the area for 3 to 5 minutes, rinse thoroughly then repeat the application.
  • Use it at least two times a week.

Sulfur and salicylic acid (Pernox) Dose in Children

Sulfur and salicylic acid (Pernox) Dose in the treatment of Dandruff (scalp seborrhea):

• Adolescents:

  • Topical: Shampoo:
    • Wet the scalp or the affected skin and massage enough of the shampoo to form a lather. Massage the area for 3 to 5 minutes, rinse thoroughly then repeat the application.
    • Use it at least two times a week.

Pregnancy Risk Category: C

• Refer to salicylic acid monograph

Use during breastfeeding:

• Refer to salicylic acid monograph

Dose in Renal disease:

No dosage adjustments have been recommended.

Dose in Liver Disease:

No dosage adjustments have been recommended.

Contraindications to Sulfur and salicylic acid (Pernox):

Patients with seborrheic and psoriasis should avoid using it on a larger area of their bodies.

Warnings and precautions

• Hypersensitivity reactions

  • Salicylic acid is used in the formulation. It may also contain benzoyl peroxide. 
  • These drugs can cause severe skin irritations and sometimes even life-threatening allergic reactions.
  • It is unclear which ingredient of the formulation causes these severe reactions.
  • The drug may cause skin hypersensitivity reactions that can be seen within minutes or days. 
  • These reactions can manifest as skin redness, itching, burning, dryness and swelling.
  • Patients should immediately stop taking the medication and seek medical attention if symptoms occur. 
  • Suppose the patient experiences severe symptoms such as tightness in the throat, breathing difficulties, dizziness, facial swelling or swelling around the eyes, lips or tongue. In that case, it is important to seek emergency medical attention immediately.
  • To ensure that allergic reactions do not occur, it is recommended that you apply OTC products to a small area of your body for at least three days.

Monitoring Parameters:

None mentioned.

How to administer Sulfur and salicylic acid (Pernox)?

It is only meant to be used outside. Avoiding making eye contact is advised. Before usage, the solution is well shaken.

Mechanism of action of Sulfur and salicylic acid (Pernox):

The keratolytic activity of both the formula components (Salicylic acid, and sulfur) is synergistic. They promote skin peeling and the breakdown of keratin.

Absorption

• Approximately 1% of topically applied sulfur is absorbed

Metabolism:

• Sulfur can be reduced to hydrogen sulfide.

International Brand Names of Sulfur and salicylic acid:

• ala seb
• Pernox
• Sebex
• Sebulex
• Dermax
• Klenyl
• Meted
• Salicylic Acid & Sulphur Cream
• Same-Seb
• Sastid
• Sastid AC
• Sastid Jabon
• Sastid Plain
• Sastid Soap
• Sevorex

Sulfur and salicylic acid Brand Names in Pakistan:

No Brands Available in Pakistan.