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Dear Readers! I started this blog when my daughter was in the NICU. She had ventriculitis. Her CSF report grew E.coli. But, she was injected Teicoplanin directly into her brain. The doctors made two errors here:

Teicoplanin is for gram-positive bacteria only. It does not treat E.coli.
Teicoplanin is not for intraventricular use. The manufacturer strongly discourage injecting Teicoplanin into the brain.

My daughter bled into the brain. She lived for another two years and ultimately died.

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Vitamin A and D Ointment Uses

Topical Vitamin A and D ointment uses are attributed to the moisturizing effects of the constituents. Vitamin A and D ointments moisturize the skin and prevent dry, scaly, rough, itchy skin and minor irritation.

Vitamin A and D Ointment Use:

Treatment and prevention of a diaper rash
Protection of sore skin
Sealing the skin
Temporary protection of skin due to minor skin scrapes, cuts, minor burns, and relief of sore skin

Vitamin A and D ointment on the face

Because of the moisturizing impact of vitamin D and the anti-inflammatory and keratolytic effect of Vitamin A, people with cracked and dry lips and faces find it a lot helpful. It is also used to treat acne vulgaris. Adapalene is an over-the-counter available topical vitamin A derivative that is used for acne vulgaris. Other home remedies used for the treatment of acne include topical vitamin C and witch hazel.

Topical Vitamin A and vitamin D Dose in Adults

Vitamin A and D Ointment dose as Skin protectant:

Apply to affected areas as needed.

Topical Vitamin A and vitamin D Dose in Children

Vitamin A and D Ointment dose for the treatment and prevention of a Diaper rash:

The ointment should be applied after changing the diaper and anytime prolonged exposure to wet diapers may occur such as at night.

Dose as Skin protectant:

Apply as and when needed.

Pregnancy & Lactation:

The risks and benefits should be weighed. It should better be avoided during pregnancy and lactation.

Topical Vitamin A and vitamin D Dose in Renal Disease:

The manufacturer's labeling does not provide any dose adjustment in patients with renal disease.

Topical Vitamin A and vitamin D Dose in Liver Disease:

The manufacturer's labeling does not provide any dose adjustment in patients with liver disease.

Side effects of Topical Vitamin A and D

Local:
- Local irritation may occur

Contraindication to Topical Vitamin A and vitamin D:

The manufacturer has not listed any contraindications.

Warnings and Precautions

Use it in the right way:
- It should only be used for external purposes.
- Avoid contact with the eyes
- You should not use it on areas with exposed skin, burns or animal bites, lacerations, and deep puncture wounds.
Self-medication (OTC):
- If symptoms persist for longer than seven days or worsen, consult a healthcare provider

Vitamin A and vitamin D (systemic): Drug Interaction

Risk Factor C (Monitor therapy)
Calcium Salts	Enhances the hazardous or harmful effects of vitamin D analogues.
Cardiac Glycosides	Cardiac Glycosides' arrhythmogenic impact may be increased by vitamin D analogues.
Danazol	Could make vitamin D analogues' hypercalcemic impact stronger.
Thiazide and Thiazide-Like Diuretics	Could make vitamin D analogues' hypercalcemic impact stronger. the adverse/toxic effect of Vitamin D Analogs.
Risk Factor D (Consider therapy modification)
Bexarotene (Topical)	Bexarotene's harmful or toxic effects could be exacerbated by vitamin A. (Topical). Treatment: If topical bexarotene is used in conjunction with vitamin A, dosages should be kept to 5,000 units per day.
Bile Acid Sequestrants	May lower the level of vitamin D analogues in the serum. Bile acid sequestrants especially may hinder the absorption of vitamin D analogues. Avoid administering bile acid sequestrants and vitamin D analogues at the same time for management (eg, cholestyramine). To reduce the chance of an interaction, administer these drugs several hours apart. track the levels of calcium in the plasma.
Erdafitinib	The therapeutic benefit of erfatinib may be diminished by serum phosphorus level-altering drugs. Management: Before the initial dose increase period depending on serum phosphate levels, avoid coadministering erdafitinib with medications that affect serum phosphate levels (Days 14 to 21).
Mineral Oil	May lower the level of vitamin D analogues in the serum. Mineral oil especially may prevent the absorption of Vitamin D analogues. Management: Prevent taking oral vitamin D analogues and mineral oil at the same time. To reduce the chance of an interaction, think about giving these medications at different times. track the levels of calcium in the plasma.
Orlistat	May lower the level of vitamins in the serum (Fat Soluble). Treatment: Give orally absorbed fat-soluble vitamins at least two hours before or after taking orlistat. When fat-soluble vitamins are delivered parenterally, same precautions are not necessary.
Orlistat	May lower the level of vitamin D analogues in the serum. Orlistat may specifically hinder the absorption of vitamin D analogues. If administered with orlistat, closely monitor the clinical response (including serum calcium) to oral vitamin D analogues. Consider administering the vitamin D analogue at least two hours before or after the orlistat if this combination is required.
Risk Factor X (Avoid combination)
Aluminum Hydroxide	Aluminum Hydroxide levels in the serum may rise while using vitamin D analogues. In particular, there may be an increase in aluminium absorption, which would raise serum aluminium contents.
Multivitamins/Fluoride (with ADE)	Enhances the hazardous or harmful effects of vitamin D analogues.
Multivitamins/Minerals (with ADEK, Folate, Iron)	Enhances the hazardous or harmful effects of vitamin D analogues.
Retinoic Acid Derivatives	Retinoic Acid Derivatives' harmful or toxic effects may be exacerbated by vitamin A. Adapalene, Alitretinoin (Topical), Bexarotene (Topical), and Tretinoin are exceptions (Topical).
Sucralfate	The serum concentration of sucralfate may rise in response to vitamin D analogues. In particular, there may be an increase in the serum aluminium concentration as a result of enhanced aluminium absorption from sucralfate.
Vitamin D Analogs	Enhances the hazardous or harmful effects of vitamin D analogues.

Monitor:

None required

How to apply topical Vitamin A and vitamin D?

It is used for external applications only. Contact with the eyes should be avoided.
The affected area should be cleaned with water and mild soap and allowed it to dry thoroughly before applying.
Apply directly to the affected area or by spreading on a clean cloth or a sterile gauze and then apply it.
Do not use it on exposed skin, animal bites, deep or puncture wounds, severe burns, or lacerations. A loose bandage may be applied.

Topical Vitamin A and D mechanism of action:

The maintenance of healthy skin requires vitamin D. The preservation of healthy skin depends on vitamin D. It is essential for cell proliferation, differentiation, and apoptosis (programmed death).
Lack of Vitamin D results in conditions like atopic dermatitis and psoriasis.
Patients with psoriasis are increasingly using Calcipotriene, a topical vitamin D Calcipotriene.
Topical Vitamin A modulates cellular differentiation, keratinization, and inflammation in the skin.