PARTIAL HEMATOLOGICAL REMISSION IN CML is defined as:
- Wbc count <10000.
- Platelet count <50% of pretreatment count but greater than 450000.
- Persistent splenomegaly but <50%of pretreatment extent.
COMPLETE HEMATOLOGICAL REMISSION:
- WBCS <10000.
- Platelat count <450000.
- No immature cells such as blasts, promyelocytes & metamyelocytes.
- Disapperance of palpable spleen.
CYTOGENETIC REMISSION:
- normal chromosomes return with 0% Philadelphia chromosomes. This is detected by karyotyping or FISH technique.
- Major cytogenetic response:0-35%
- Ph chromosomes.
Minor cytogenetic response:
- 1-34% Philadelphia positive chromosomes.
MOLECULAR RESPONSE:
- there should be negative PCR results for BCR/ABL mRNA. Detected by measuring quantitave pcr.
Complete molecular response:
- BCR-abl mRNa undetected by PCR.
Major molecular response:
- > 3 log reduction of bcr-abl mRNA which should be acheived within 12 months.
Maryum batool,
3 years ago