Chronic Myeloid Leukemia (CML)

Author: owner     Published: 3 years ago 2 Replies

What are the stages of CML (Chronic Myeloid leukemia)?

There are 3 stages of CML.

  1. Chronic phase,
  2. Accelerated phase &
  3. Blast phase.

CHRONIC PHASE:

  • It is characterized by less than 10% blast cells in blood & bone marrow.
  • Wbc capable of fighting infections.

ACCELERATED PHASE:

  • 10-19% blast cells in blood & bone marrow.
  • High basophil count >20% of wbcs.
  • Persistent thrombocytopenia unrelated to therapy.
  • Persistent thrombocytosis.
  • Increasing wbcs & spleen unresponsive to therapy.
  • There is fever, poor appetite & weight loss.

BLAST CRISIS:

  • > 25% blast cells in blood & bone marrow.
  • There is fever, loss of apetite, weight loss, fatigue, bleeding, infections common, bone pain. 
Maryum batool, 3 years ago

PARTIAL HEMATOLOGICAL REMISSION IN CML is defined as:

  • Wbc count <10000.
  • Platelet count <50% of pretreatment count  but greater than 450000.
  • Persistent splenomegaly but <50%of pretreatment extent.

COMPLETE HEMATOLOGICAL REMISSION:

  • WBCS <10000.
  • Platelat count <450000.
  • No immature cells such as blasts, promyelocytes & metamyelocytes.
  • Disapperance of palpable spleen.

CYTOGENETIC REMISSION:

  • normal chromosomes return with 0% Philadelphia chromosomes. This is detected by karyotyping or FISH technique.
  • Major cytogenetic response:0-35%
  •  Ph chromosomes.

Minor cytogenetic response:

  • 1-34% Philadelphia positive chromosomes.

MOLECULAR RESPONSE: 

  • there should be negative PCR results for BCR/ABL mRNA. Detected by measuring quantitave pcr.

Complete molecular response:

  • BCR-abl mRNa undetected by PCR.

Major molecular response:

  • > 3 log reduction of bcr-abl mRNA which should be acheived within 12 months. 
Maryum batool, 3 years ago

Login to Reply

Money Back Guarantee
We return Money in 24 Hours

Secure online payment
We possess SSL / Secure Certificate

12/7 customer support
Well-trained & Supportive team

PMDC Verified Doctors
Authentic & updated information

emedz.net

Book Online and In-clinic appointments with your doctor. Consult via Video chat and get a prescription. Ask any question in the "Forum" section and get a detailed answer. Discuss your health issues. Advertisers who wish to place ads on emedz.net and reach multiple users can contact here: ads@emedz.net

Connect with us

Copyright @ 2024 - All Rights Reserved Reproduction of material from any pages without permission is strictly prohibited.