Magnesium Glycinate Vs Magnesium Bisglycinate

Criteria	Magnesium Glycinate	Magnesium Bisglycinate
Chemical Structure	Magnesium bound to one glycine molecule	Magnesium bound to two glycine molecules
Bioavailability	High (easily absorbed)	Very high (possibly higher than glycinate)
Absorption	Gentle on the stomach, well-absorbed	Superior absorption due to dual glycine attachment
Form	Chelated magnesium (bound to amino acid)	Bis-chelated magnesium (two glycine molecules)
Stomach Tolerance	Low risk of diarrhea	Lower risk of diarrhea (better tolerated)
Primary Uses	- Anxiety and stress relief - Better sleep quality - Muscle relaxation - Migraine relief	- Anxiety and stress relief - Improved sleep - Enhanced cognitive function - Muscle cramps and spasms prevention
Sleep Benefits	Promotes relaxation and better sleep	Potentially more effective due to higher glycine content
Stress/Anxiety	Reduces cortisol and promotes relaxation	May have a stronger calming effect due to glycine's role in the nervous system
Digestive Impact	Gentle on digestion, rarely causes diarrhea	Even gentler on digestion, less chance of GI issues
Molecular Weight	Lower molecular weight (smaller molecule)	Higher molecular weight (larger molecule)
Supplement Form	Tablets, capsules, powders	Primarily found in powders and capsules
Ideal For	People with anxiety, sleep issues, and muscle cramps	People with anxiety, poor sleep, and sensitive stomachs
Cost	Moderate to high	Slightly more expensive due to enhanced absorption
Availability	Widely available	Available but less common than glycinate