Xenon Xe-133 is a radiolabeled gas that is used in diagnostic imaging. It is used for the assessment of cerebral blood flow, pulmonary functions, and lung imaging.
Xenon Dose in Adults
Xenon Dose in the diagnostic workup of Cerebral blood flow:
- Inhalation (based on 70 kg patient): 10 to 30 mCi (370 to 1,110 MBq) in 3 liters of air.
Xenon Dose to evaluate Pulmonary functions, including imaging:
- Inhalation (based on 70 kg patient): 2 to 30 mCi (74 to 1,110 MBq) in 3 liters of air
Xenon Dose in Children
It has not been studied in children.
Pregnancy Risk Factor C
- Even though it has not yet been tested in pregnant women, radiopharmaceuticals are contraindicated for pregnant patients.
- A pregnancy test is required before the drug can be administered to females with reproductive potential.
Xenon use during breastfeeding:
- It is unknown if the drug will be excreted into breast milk.
- When administering the agent, the manufacturer suggests that you stop breastfeeding and replace formula milk with breast milk.
Dose in kidney disease:
The manufacturer has not recommended any adjustment in the dose in patients with kidney disease.
Dose in patients with liver disease:
The manufacturer has not recommended any adjustment in the dose in patients with liver disease.
Side effects of Xenon gas:
The manufacturer has not listed any adverse effects of the gas.
Contraindications and warnings:
The manufacturer has not listed any specific warnings or contraindications to its use.
Monitor:
No specific monitoring parameters are required.
How to administer Xenon?
- It is administered by inhalation from a spirometer or closed respirator system.
- The respirator system should be leakproof. It should not be allowed to stand in the tubing or the containers.
- The dose should be measured immediately prior to administration with a suitable radioactivity calibration system.
- Since it is a radiopharmaceutical drug, it should be used with appropriate precautions for handling and disposal.
- Waterproof gloves and effective radiation shielding should be used when handling the drug.
Mechanism of action of Xenon:
- It is a radioactive diagnostic agent that can pass through cell membranes and exchange freely between blood and tissues.
- It is inhaled through the capillaries and enters the alveolar wall.
- The majority of inhaled gases enter the circulation, are returned to the lungs, and then exhaled.
- It is used in diagnostic radiology in extremely low doses, which is physiologically inactive. It is found in body fats, blood, plasma, water, or protein solutions, with a half-life of approximately 5.3 days.