Fusidic acid and Betamethasone (Fucibet) is a combination of topical corticosteroid and topical antibiotic that is used to treat dermatosis with superinfection.

Fusidic acid and betamethasone Uses:

• Corticosteroid-responsive dermatoses with secondary infection:

  • It is recommended for the treatment of inflammatory dermatoses that respond to corticosteroids, such as atopic eczema, discoid eczema, stasis eczema, and seborrheic eczema, and which have a possible subsequent bacterial infection from Staphylococcus aureus.

Fusidic acid and Betamethasone (Fucibet) Dose in Adults

Fusidic acid and Betamethasone (Fucibet) Dose in the treatment of Corticosteroid-responsive dermatoses with secondary infection:

• Topical: Apply twice daily to the afflicted region.
• Generally, the treatment shouldn't go longer than 14 days.

Fusidic acid and Betamethasone (Fucibet) Dose in Children

Fusidic acid and Betamethasone (Fucibet) Dose in the treatment of Corticosteroid-responsive dermatoses with secondary infection:

• Children ≥6 years and Adolescents:

  • Refer to adult dosing;
  • Avoid use over an extensive surface for a longer time, using large amounts, and use of occlusive dressings.

Use during pregnancy and breastfeeding:

• Animal reproduction studies have shown adverse pregnancy outcomes.
• Talk to individual agents.

Use during breastfeeding:

• Both fusidic acid as well as betamethasone can be found in breast milk. Avoid direct application to the breasts.
• Manufacturers recommend that you only use it if there are no risks.
• Refer to individual agents (Betamethasone, Fusidic acid).

Dose in Kidney Disease:

No dosage adjustment is necessary.

Dose in Liver disease:

No dosage adjustment is necessary.

Side effects of Fucibet:

See individual agents (Betamethasone and Fusidic acid)

Contraindications:

• Allergies to betamethasone, fusidic acid, or any other ingredient in the formulation
• Primary skin infection caused by bacteria, viruses, or fungi;
• Systemic fungal infections;
• Skin tuberculosis, or syphilis
• Perioral dermatitis;
• Acne Rosacea;
• Skin eruption after vaccinations

Warnings and precautions

• Suppression of the adrenals:

  • The possibility of systemic absorption can lead to hypercortisolism, which can depress the hypothalamic-pituitary-adrenal (HPA) axis.
  • Patients who are younger, use longer amounts of medication, or use occlusive dressings such as diapers, may experience HPA suppression.

• Immunosuppression:

  • Corticosteroids, including topical corticosteroids, can suppress immunity, trigger secondary infections, activate latent infection, prolong or exacerbate viral infections, and may even cause secondary infections. Because of its anti-inflammatory properties, it may mask symptoms of fungal infection.

• Ocular effects

  • Topical corticosteroids have been linked to an increased risk of glaucoma, subcapsular and posterior subcapsular cataracts.
  • Ocular symptoms should be checked on patients. Avoid direct contact with the eyes.

• Reactions to skin:

  • Long-term use can cause local skin reactions. These could include:
    • Rosacea
    • Erythema
    • Hypertrichosis
    • Perioral dermatitis
    • Skin striae
    • Telangiectasia
    • Atrophy of the skin
    • Contact dermatitis
    • Acneiform dermatitis
    • Hyperhidrosis
    • Depigmentation
    • Ecchymosis.

• Antibiotic resistance and superinfection:

  • Antibiotic resistance may develop if antibiotics are used for too long.
  • If superinfection is suspected, the treatment should be stopped immediately. The patient should be assessed and treated accordingly.
  • The treatment should not last more than two weeks to reduce the chance of developing bacterial resistance.

• Systemic effects

  • Systemic absorption can occur when corticosteroids are used for an extended period of time. This could manifest as hyperglycemia or glucosuria.
  • Avoid systemic absorption by using the product over denuded skin.

Fusidic acid and betamethasone: Drug Interaction

Monitoring parameters:

• Adrenal functions should be monitored in patients on prolonged or extensive use of topical corticosteroids.
• Monitor the response to treatment;
• Ocular changes

How to administer Fucibet?

• It is indicated for external use over skin only.
• It is not recommended around or inside the eyes.

Mechanism of action:

See individual agents (Betamethasone and Fusidic acid)

International Brand Names:

• Fucibet
• Aceler-Co
• Acifusion B
• Defuzin-B
• Dermorutex B
• Disuf-B
• Drum B
• Ezaderm
• Fisibact
• Fucibet
• Fucibet Lipid Cream
• Fucicort
• Fucitopic
• Fusibact B
• Fusidasol
• Fusiderm-B
• Fusigal
• Fusimed B
• Fusimed-B
• Futasone
• Germacort
• Inferuderm B
• Mexiderm-F
• Topizone
• Veruderm B
• Verutex B
• Xzema
• Zeta-Cort

Fusidic acid and Betamethasone Brand Names in Pakistan: